Home‐Based Exercise Training Improves Left Ventricle Diastolic Function in Survivors of Childhood ALL: A Tissue Doppler and Velocity Vector Imaging Study

Järvelä, Liisa S.; Saraste, Markku; Niinikoski, Harri; Hannukainen, Jarna C.; Heinonen, Olli J.; Lähteenmäki, Päivi; Arola, Mikko; Kemppainen, Jukka

doi:10.1002/pbc.26051

Cited by 20 publications

(38 citation statements)

References 40 publications

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“…One study [8] reported that FS was preserved and reduced in the exercise and control groups, respectively, whereas in the studies by Järvelä et al [28,30], in which no control group was included, the FS was also preserved after exercise. One study [30] analyzed LV structure, finding an increase in early diastolic mitral inflow velocity and peak circumferential strain rate and diastolic strain rate after exercise. Two studies analyzed endothelial function and structure through vascular ultrasound.…”

Section: Cardiovascular Function and Structurementioning

confidence: 98%

“…Two participants from two studies were excluded because they had noncancer-related hematological disorders [12,33]. Some studies ana-lyzed the same sample (Braam et al [20,21], Järvela et al [28][29][30], Riggs et al [39], and Piscione et al [38]), and thus we used only one study in each case to compute the total number of subjects.…”

Section: Characteristics Of Participants and Interventionsmentioning

confidence: 99%

“…Four studies assessed echocardiography-determined LV systolic function [8,28,30,40]. Järvelä et al [28,30] used the same sample, and thus we could only meta-analyze three studies. Overall, LVEF was maintained with the exercise intervention (n = 44, MD = 0.29 %, 95 %CI = -1.41-1.99, p = 0.738, ▶Fig.…”

Section: Cardiovascular Function and Structurementioning

confidence: 99%

“…Although the effects on FS were analyzed in three studies, two of them [28,30] shared the same sample, and thus we could not meta-analyze this endpoint. One study [8] reported that FS was preserved and reduced in the exercise and control groups, respectively, whereas in the studies by Järvelä et al [28,30], in which no control group was included, the FS was also preserved after exercise. One study [30] analyzed LV structure, finding an increase in early diastolic mitral inflow velocity and peak circumferential strain rate and diastolic strain rate after exercise.…”

Section: Cardiovascular Function and Structurementioning

confidence: 99%

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Exercise Interventions and Cardiovascular Health in Childhood Cancer: A Meta-analysis

et al. 2020

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This study analyzed the effects of physical exercise interventions on cardiovascular endpoints in childhood cancer survivors. Relevant articles were systematically searched in PubMed, CINAHL, and Web of Science databases (since inception to 11th September 2019). We performed a meta-analysis (random effects) to determine the mean difference (expressed together with 95% confidence intervals) between pre- and post-intervention values for those cardiovascular endpoints reported in more than three studies. Twenty-seven studies (of which 16 were controlled studies) comprising 697 participants were included. Only three studies reported adverse events related to exercise interventions. Exercise resulted in an increased performance on the 6-minute walk distance test (mean difference=111 m, 95% confidence interval=39–183, p=0.003) and a non-significant trend (mean difference=1.97 ml∙kg−1∙min−1, 95% confidence interval=−0.12–4.06, p=0.065) for improvement in peak oxygen uptake. Furthermore, left ventricular ejection fraction was preserved after exercise interventions (mean difference=0.29%, 95% confidence interval=−1.41–1.99, p=0.738). In summary, exercise interventions might exert a cardioprotective effect in childhood cancer survivors by improving – or attenuating the decline of – physical capacity and cardiovascular function. Further studies, particularly randomized controlled trials, are needed to confirm these benefits.

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Section: Cardiovascular Function and Structurementioning

confidence: 98%

Section: Characteristics Of Participants and Interventionsmentioning

confidence: 99%

Section: Cardiovascular Function and Structurementioning

confidence: 99%

Section: Cardiovascular Function and Structurementioning

confidence: 99%

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Exercise Interventions and Cardiovascular Health in Childhood Cancer: A Meta-analysis

et al. 2020

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“…These studies can be classified in three main categories: home-based, web-based or supervised physical activity interventions. A home-based intervention with asymptomatic childhood acute lymphoblastic leukaemia survivors included a three-month exercise programme and reported an improved cardiac function, in terms of a significant improvement of the attenuated left ventricle diastolic function [51]. Another home-based intervention where participants met physical activity guidelines and wore a motivational activity tracker over a six-month period led to an increased, but not statistically significant, moderate to vigorous physical activity and maximum oxygen uptake (VO 2 max ) [52].…”

Section: Lifestyle Interventionsmentioning

confidence: 99%

Comprehensive assessments and related interventions to enhance the long-term outcomes of child, adolescent and young adult cancer survivors – presentation of the CARE for CAYA-Program study protocol and associated literature review

et al. 2020

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Background: Improved, multimodal treatment strategies have been shown to increase cure rates in cancer patients. Those who survive cancer as a child, adolescent or young adult (CAYA), are at a higher risk for therapy-, or diseaserelated, late or long-term effects. The CARE for CAYA-Program has been developed to comprehensively assess any potential future problems, to offer need-based preventative interventions and thus to improve long-term outcomes in this particularly vulnerable population.

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Inflammatory biomarkers after an exercise intervention in childhood acute lymphoblastic leukemia survivors

Taalas

Järvelä

Niinikoski

et al. 2022

eJHaem

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Cancer survivors show increased risk for non-communicable diseases and chronic lowgrade inflammation characterizes the development of such diseases. We investigated inflammatory plasma protein profiles of survivors of childhood acute lymphoblastic leukemia (ALL) in comparison to healthy controls and after an intervention with a home-based exercise program. Survivors of childhood ALL aged 16-30 years (n = 21) with a median age at diagnosis 4.9 (1.6-12.9) years and a median time of 15.9 years from diagnosis, and sex-and age-matched healthy controls (n = 21) were studied. Stored plasma samples were analyzed with Olink's 92-protein-wide Inflammation panel in 21 ALL long-term survivors at baseline, after a previous 16-week home-based exercise intervention (n = 17) and in 21 age-and sex-matched controls at baseline. Protein expression levels were compared between the groups. Inflammatory protein levels did not differ between the survivors and controls at baseline. Significantly reduced levels after the intervention were found in 11 proteins related to either vascular inflammation, insulin resistance, or both: tumor necrosis factor superfamily member 14 (TNFSF14), oncostatin M (OSM), monocyte chemoattractant protein 1 (MCP-1), MCP-2, fibroblast growth factor 21 (FGF-21), chemokine (C-C motif) ligand 4 (CCL4), transforming growth factor alpha (TGF-α), tumor necrosis factor-related apoptosisinducing ligand 10 (TRAIL), adenosine deaminase (ADA), chemokine (C-X-C motif) ligand 6 (CXCL6), and latency-associated peptide transforming growth factor beta 1

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Home‐Based Exercise Training Improves Left Ventricle Diastolic Function in Survivors of Childhood ALL: A Tissue Doppler and Velocity Vector Imaging Study

Cited by 20 publications

References 40 publications

Exercise Interventions and Cardiovascular Health in Childhood Cancer: A Meta-analysis

Exercise Interventions and Cardiovascular Health in Childhood Cancer: A Meta-analysis

Comprehensive assessments and related interventions to enhance the long-term outcomes of child, adolescent and young adult cancer survivors – presentation of the CARE for CAYA-Program study protocol and associated literature review

Inflammatory biomarkers after an exercise intervention in childhood acute lymphoblastic leukemia survivors

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