Home intravenous antibiotics for cystic fibrosis

Balaguer, Albert; J, González de Dios

doi:10.1002/14651858.cd001917.pub2

Cited by 12 publications

(6 citation statements)

References 27 publications

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“…The reviewers demanded more randomised trials. 23,24 Factors such as closer observations and more intense treatment such as physiotherapy and dietetic input in hospital were thought to be the cause of better outcome.…”

Section: Discussionmentioning

confidence: 99%

Extending the course of intravenous antibiotics in adult patients with cystic fibrosis with acute pulmonary exacerbations

Sequeiros

Jarad

2012

Chron Respir Dis

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Section: Discussionmentioning

confidence: 99%

Extending the course of intravenous antibiotics in adult patients with cystic fibrosis with acute pulmonary exacerbations

Sequeiros

Jarad

2012

Chron Respir Dis

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“…This significantly shorter duration yielded similar improvement in PFTs compared to the longer duration of home treatment. Cochrane review by Balaguer and Gonzalez de Dios found that maximal recovery of lung function occurs within the first 8 days of therapy with intravenous antibiotics at the hospital [18]. Nazer et al demonstrated that even patients with different disease severity levels improved more and in a shorter time when treated at the hospital [19].…”

Section: Discussionmentioning

confidence: 99%

Hospital versus Home Treatment for Respiratory Exacerbations in Cystic Fibrosis - a Multilevel Comparison

et al. 2011

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SummaryBackgroundTreatment of respiratory exacerbations in Cystic Fibrosis (CF) is important in slowing disease progression. The treatment may be given either at home or at the hospital. The aim of our study was to compare both treatment settings.Material/MethodsWe retrospectively analyzed data of 139 treatments in 54 CF patients (age range12–47 y) treated for respiratory exacerbations at the hospital (n=84) and/or at home (n=55). Primary outcomes were improvement in pulmonary function tests (PFTs), weight gain and duration of treatment in relation to treatment setting. Secondary outcomes were these same parameters, but in relation to different clinical preconditions and CF-related complications.ResultsMean improvement in FEV1 (% predicted) was similar between the hospital and home treatments (14.3±34.4% vs. 14.3±20.2%, respectively; NS), yet treatment duration was significantly shorter at the hospital (9.7±6.7 vs. 16.3±9.1 days, respectively; P<0.02), especially for patients colonized with Pseudomonas aeruginosa (11.1±5.5 vs. 18.0±11.0 days, respectively; p<0.01). At the hospital, a subgroup of patients with CF-related complications improved their FEV1 significantly more than those at home (13.1±19.4% vs. 1.9±14.9%, respectively; P<0.02), particularly patients with CF-related diabetes mellitus (CFRDM) (11.4±18.7% vs. 1.7±14.6%, respectively; P<0.05). Patients tended to gain more weight at the hospital compared to home treatment (1.36±4.6 kg and 0.49±3.6 kg respectively; P=0.06).ConclusionsHospital treatment for acute respiratory exacerbations in CF may be superior to home treatment, as indicated by a shorter duration of hospitalization, better improvement in FEV1 in patients with CF-related complications, CFRDM in particular and a trend toward better weight gain.

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“…However their use in specific CF paediatric populations has been rarely described [24]. Since home antibiotic therapy increases the patients' quality of life [25], we aimed to evaluate the feasibility and tolerance of a new central catheters introduced by a peripheral vein for home antibiotic treatment in our CF population.…”

Section: Introductionmentioning

confidence: 99%

Intravenous peripherally-inserted central catheters for antibiotic therapy in children with cystic fibrosis

Bui

Babre

Hauchecorne

et al. 2009

Journal of Cystic Fibrosis

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Home intravenous antibiotics for cystic fibrosis

Abstract: Editorial group: Cochrane Cystic Fibrosis and Genetic Disorders Group. Publication status and date: New search for studies and content updated (no change to conclusions), published in Issue 4, 2010. Review content assessed as up-to-date: 16 March 2010.

Cited by 12 publications

References 27 publications

Extending the course of intravenous antibiotics in adult patients with cystic fibrosis with acute pulmonary exacerbations

Extending the course of intravenous antibiotics in adult patients with cystic fibrosis with acute pulmonary exacerbations

Hospital versus Home Treatment for Respiratory Exacerbations in Cystic Fibrosis - a Multilevel Comparison

Intravenous peripherally-inserted central catheters for antibiotic therapy in children with cystic fibrosis

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