Home Oral Care with Biomimetic Hydroxyapatite vs. Conventional Fluoridated Toothpaste for the Remineralization and Desensitizing of White Spot Lesions: Randomized Clinical Trial

Butera, Andrea; Gallo, Simone; Pascadopoli, Maurizio; Montasser, Mona A.; Latief, Mohammad H Abd El; Modica, Gioia Giada; Scribante, Andrea

doi:10.3390/ijerph19148676

“…Additionally, the protective efects of these fuoride varnishes were evaluated without mechanical action, which can be considered another limitation of this study. Notably, a recent study showed that the use of a toothpaste containing hydroxyapatite could be a more reliable method for the domiciliary management of WSLs than the use of conventional fuoride toothpaste [37]. It might be interesting to compare the efcacy of toothpaste containing biomimetic hydroxyapatite with that of the two varnishes investigated in this study.…”

Section: Discussionmentioning

confidence: 94%

An In Vitro Comparison of Clinpro™ XT and Duraphat Varnish for Protecting Teeth from Discoloration during Orthodontic Treatment

Xu

¹

,

Zou

²

,

Lin

³

et al. 2023

International Journal of Clinical Practice

0

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Objective. During orthodontic treatment, a higher caries risk has been reported, so fluorides and other remineralizing compounds have been proposed. Currently, fluoride varnish is commonly available in conventional and light-curable forms. This in vitro study was performed to evaluate the effectiveness of two different materials, Clinpro™ XT (light-curable forms) and Duraphat (conventional forms) varnish, whose main active principle according to their manufacturers is fluoride in preventing tooth discoloration during orthodontic treatment with appliances attached with metal brackets or resin. Materials and Methods. This study included 120 premolars free of white spot lesions and caries that were randomly divided into the following six groups (n = 20): resin control (RCTR), resin Clinpro (RC), resin Duraphat (RD), bracket control (BCTR), bracket Clinpro (BC), and bracket Duraphat (BD). All the samples were exposed to 180 ml of coffee (4 times × 5 min/day) for 7 or 28 days. When not immersed in coffee, the teeth were stored in artificial saliva, which was replaced every day. The lightness ( L ∗ ), red/green axis ( a ∗ ), and yellow/blue axis ( b ∗ ) values were recorded with a dental spectrophotometer (Easy shade Advance 4.0) on days 0 (baseline), 7, and 28. The color difference ( Δ E ∗ ) on days 7 and 28 was also calculated. Results. The data were statistically analyzed using one-way ANOVA and Bonferroni’s test (α = 0.05). Significant differences were observed between the Δ E ∗ , L ∗ , a ∗ , and b ∗ values of the Clinpro™ XT and Duraphat groups and those of the control groups after 7 and 28 days regardless of the attachment type ( P < 0.001). On day 7, no significant differences were observed between the Clinpro™ XT and Duraphat groups, whereas on day 28, the Duraphat groups with metal and resin attachments exhibited significant differences from the Clinpro™ XT groups ( P < 0.001). No significant differences correlated to the attachment type were observed throughout the discoloration procedure. Conclusions. The application of fluoride varnish during orthodontic treatment can significantly reduce tooth discoloration caused by the staining solution. Clinpro™ XT varnish showed a longer period of efficacy in protecting teeth from discoloration than Duraphat. No differences in tooth discoloration were observed between the groups with fixed and clear appliances.

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“…After our search was completed, 4 additional studies appeared in the literature that were not included in this qualitative or quantitative synthesis [ 78 , 79 , 80 , 81 ]. These studies were consistent with HAP in reducing dentin hypersensitivity.…”

Section: Discussionmentioning

confidence: 99%

Clinical Evidence of Biomimetic Hydroxyapatite in Oral Care Products for Reducing Dentin Hypersensitivity: An Updated Systematic Review and Meta-Analysis

Limeback

¹

,

Enax

²

,

Meyer

³

2023

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Dentin hypersensitivity (DH) is a very common dental problem that can have a negative impact on the quality of life and can lead to invasive dental procedures. Prevention of DH and control of symptoms are highly desirable. Hydroxyapatite (HAP) has been shown in vitro to block dentinal tubules and in vivo to be a safe and effective additive in oral care products that reduce DH clinically. This study’s aim was to conduct a systematic review and meta-analysis of the current evidence that HAP-containing oral care products reduce DH. Databases were searched, and only clinical trials in humans were included; studies conducted in vitro or on animals were not included. Publications in a foreign language were translated and included. We found 44 published clinical trials appropriate for systematic analysis. More than half of the trials had high-quality GRADE scores. HAP significantly reduced dentin hypersensitivity compared to placebo (39.5%; CI 95% [48.93; 30.06]), compared to fluoride (23%; CI 95% [34.18; 11.82]), and with a non-significant tendency compared to other desensitizing agents (10.2%; CI 95% [21.76; −19.26]). In conclusion, the meta-analysis showed that HAP added to oral care products is a more effective agent than fluoride in controlling dentin hypersensitivity and may be superior to other desensitizers.

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“…Fluoride-free prophylactic systems have been investigated in the last decade. It has been shown that they can be as efficient as fluoride-containing systems to prevent dental caries [ 8 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 ]. Thus, they may present a viable alternative to fluoride-containing agents in oral care.…”

Section: Discussionmentioning

confidence: 99%

Incorporation of Fluoride into Human Teeth after Immersion in Fluoride-Containing Solutions

Storsberg

¹

,

Loza

²

,

Epple

³

2022

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Toothpastes and mouth rinses contain fluoride as a protective agent against caries. The aim of this study was to determine the degree of fluoride-uptake by human tooth mineral during immersion into fluoride-containing aqueous solutions as different pH. Human teeth were immersed in fluoride-containing solutions to assess the extent of fluoride incorporation into tooth enamel. A total of 16 extracted teeth from 11 patients were immersed at 37 °C for one minute into aqueous fluoride solutions (potassium fluoride; KF) containing either 250 ppm or 18,998 ppm fluoride (1-molar). Fluoride was dissolved either in pure water (neutral pH) or in a citrate buffer (pH 4.6 to 4.7). The elemental surface composition of each tooth was studied by energy-dispersive X-ray spectroscopy in combination with scanning electron microscopy and X-ray powder diffraction. The as-received teeth contained 0.17 ± 0.16 wt% fluoride on average. There was no significant increase in the fluoride content after immersion in 250 ppm fluoride solution at neutral or acidic pH values. In contrast, a treatment with a 1-molar fluoride solution led to significantly increased fluoride concentrations by 0.68 wt% in water and 9.06 wt% at pH 4.7. Although such fluoride concentrations are far above those used in mouth rinses or toothpastes, this indicates that fluoride can indeed enter the tooth surface, especially at a low pH where a dynamic dissolution-reprecipitation process may occur. However, precipitations of calcium fluoride (globuli) were detected in no cases.

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Home Oral Care with Biomimetic Hydroxyapatite vs. Conventional Fluoridated Toothpaste for the Remineralization and Desensitizing of White Spot Lesions: Randomized Clinical Trial

Cited by 40 publications

References 30 publications

An In Vitro Comparison of Clinpro™ XT and Duraphat Varnish for Protecting Teeth from Discoloration during Orthodontic Treatment

An In Vitro Comparison of Clinpro™ XT and Duraphat Varnish for Protecting Teeth from Discoloration during Orthodontic Treatment

Clinical Evidence of Biomimetic Hydroxyapatite in Oral Care Products for Reducing Dentin Hypersensitivity: An Updated Systematic Review and Meta-Analysis

Incorporation of Fluoride into Human Teeth after Immersion in Fluoride-Containing Solutions

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