Home-prepared Hamburger and Sporadic Hemolytic Uremic Syndrome, Argentina

Rivas, Marta; Caletti, María Gracia; Chinen, Isao; Refi, Stella Maris; Roldán, Carlos Daniel; Chillemi, Germán; Fiorilli, G.; Bertolotti, Alicia; Aguerre, Lorena; Estani, Sérgio Sosa

doi:10.3201/eid0909.020563

Cited by 28 publications

(18 citation statements)

References 7 publications

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“…coli serogroup O157 bacteria expressing both Stx1 and Stx2 are the microorganisms most frequently isolated from children with HUS, although strains that express only Stx2 are highly prevalent in Argentina [9,10]. The commonest source of infection is badly cooked meat [11], although a variety of food vehicles has been linked to STEC infections, including sausages, lettuce, cabbage, alfalfa sprouts and unpasteurized juices and milk [12]. Person-to-person transmission has also been identified in Argentina [13].…”

Section: Introductionmentioning

confidence: 99%

Development of an experimental hemolytic uremic syndrome in rats

et al. 2008

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Escherichia coli strains producing Shiga toxins (Stxs) colonize the lower gastrointestinal tract and cause watery diarrhea, hemorrhagic colitis, and hemolytic-uremic syndrome (HUS). HUS is characterized by hemolytic anemia, thrombocytopenia, and acute renal failure. Oliguria associated with acute tubular necrosis and microangiopathic thrombosis has been reported as the most common cause of renal failure in Argentinean children. Our study was undertaken to obtain a model of HUS in rats that was similar to the clinical and renal histopathology findings described in humans. Rats were intraperitoneally inoculated with culture supernatant from recombinant E. coli expressing Stx2. Glomerular filtrate volume evaluated from clearance of creatinine resulted in a progressive reduction (from 53% at 24 h to 90% at 48 h). Urine volume increased significantly at 24 h but returned to normal levels at 48 h. Evidence of thrombocytopenia, anemia and leukocytosis was documented. Macroscopic analysis revealed a hyperemic peritoneal face with intestinal water accumulation. The kidneys were friable and congestive. Histopathological analysis showed glomerular and tubular necrosis as well as microangiopathic thrombosis. Our findings indicated vascular damage and kidney lesions similar to those described in humans with HUS.

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Section: Introductionmentioning

confidence: 99%

Development of an experimental hemolytic uremic syndrome in rats

et al. 2008

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“…Isolates with stx1 or stx2 genes were identifi ed by standard biochemical methods. Stx-positive colonies were serotyped (24) and characterized at the Argentina National Reference Laboratory (11,25). Data analysis used 3 steps: an initial univariate analysis, a second univariate analysis adjusted for highly signifi cant factors of prior or secondary interest, and a fi nal multivariable model-building analysis.…”

Section: Laboratory Methodsmentioning

confidence: 99%

“…STEC has been isolated from the feces of many farm animals, including ruminants (e.g., cattle, sheep, and water buffalo) and nonruminants (e.g., horses, dogs, rabbits, and pigs) (8)(9)(10). STEC infections are transmitted to humans through contaminated food (11), water (12,13), and contact with infected persons (14) or animals (15,16).…”

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confidence: 99%

Risk Factors for Sporadic Shiga Toxin–producingEscherichia coliInfections in Children, Argentina1

Rivas

Sosa-Estáni²,

Rangel

et al. 2008

Emerg. Infect. Dis.

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We evaluated risk factors for sporadic Shiga toxin-producing Escherichia coli (STEC) infection among children in Argentina. We conducted a prospective case-control study in 2 sites and enrolled 150 case-patients and 299 controls. The median age of case-patients was 1.8 years; 58% were girls. Serotype O157:H7 was the most commonly isolated STEC. Exposures associated with infection included eating undercooked beef, living in or visiting a place with farm animals, and contact with a child <5 years of age with diarrhea. Protective factors included the respondent reporting that he or she always washed hands after handling raw beef and the child eating more than the median number of fruits and vegetables. Many STEC infections in children could be prevented by avoiding consumption of undercooked beef, limiting exposure to farm animals and their environment, not being exposed to children with diarrhea, and washing hands after handling raw beef.

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“…Las vías de transmisión de STEC que puede derivar en SUH son múltiples. La principal vía es la ingesta de alimentos contaminados como la carne picada y otros productos cárnicos crudos o insuficientemente cocidos, hamburguesas, embutidos 211 fermentados, leche no pasteurizada, yogur, quesos y mayonesas (WORLD HEALTH ORGANIZATION 1997;RIVAS et al, 2003). No obstante, los alimentos no son la única vía de transmisión ya que se han comprobado contaminaciones asociados a la ingesta de agua no clorada, al uso de piletas de natación (CASTOR y BEACH, 2005) y la recreación en lagos contaminados (PÉREZ et al, 2000).…”

Section: Introductionunclassified

Conocimiento científico y problemas de salud. Una enfermedad emergente en Argentina, el Síndrome Urémico Hemolítico

Belardo¹

2014

Physis

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Resumen: El artículo analiza la relación entre la producción de conocimiento científico y una enfermedad infantil llamada Síndrome Urémico Hemolítico. Nuestro objetivo es hacer hincapié en la forma en que la ciencia biomédica construye una forma de "mirar" y definir los problemas sociales, que en este caso es un problema de salud que afecta, principalmente en Argentina, a la población menor de cinco años de edad, y cómo a partir de esas características objetivas definidas por biomedicina, la salud pública, ha sostenido formas de abordar e intervenir en el asunto. A partir de una metodología cualitativa, la recolección de datos se llevó a cabo a través de un conjunto de técnicas que incluyó el análisis de fuentes secundarias tales como la revisión de los artículos científicos sobre la enfermedad, entrevistas semi-estructuradas con científicos y funcionarios públicos y la observación directa de los debates que se produjeron en distintas conferencias en torno a las propuestas de intervención para prevenir y controlar a la enfermedad. Se presentan las principales características por las cuales la biomedicina comprendió a la enfermedad para luego analizar las implicancias que tuvo en el diseño de políticas de salud. La planificación de políticas de salud siguió la lógica de la producción de conocimiento científico. Los nuevos descubrimientos que se fueron produciendo a lo largo del tiempo cambiarán casi de forma lineal el diseño de las políticas de prevención y control de la enfermedad. Palavras-chave: conocimiento científico; paradigma epidemiológico; políticas de salud; Síndrome Urémico Hemolítico.

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Home-prepared Hamburger and Sporadic Hemolytic Uremic Syndrome, Argentina

Cited by 28 publications

References 7 publications

Development of an experimental hemolytic uremic syndrome in rats

Development of an experimental hemolytic uremic syndrome in rats

Risk Factors for Sporadic Shiga Toxin–producingEscherichia coliInfections in Children, Argentina1

Conocimiento científico y problemas de salud. Una enfermedad emergente en Argentina, el Síndrome Urémico Hemolítico

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