“…Adults with SMI, such as schizophrenia, bipolar and re-occurring major depressive disorders suffer from high rates of SUDs, with lifetime rates as high as 50% (Regier et al, 1990). Relative to people with only one of these conditions, individuals with co-occurring SMIs and SUDs have more severe substance use and psychiatric symptoms (RachBeisel et al, 1999), poorer treatment adherence (Bennett et al, 2001), increased homelessness (Galanter et al, 1998), and higher rates of smoking (de Leon et al, 2007), HIV infection (RachBeisel et al, 1999), psychiatric hospitalization (Haywood et al, 1995), emergency room use (Bartels et al, 1993) and incarceration (Abram and Teplin, 1991). The high rates of SUDs among individuals with SMI, and the consequences of this comorbidity, directly contribute to the high economic cost of SMI in the U.S., which is estimated to be well over $400 billion (2013 USD) annually (Insel, 2008).…”