2021
DOI: 10.1038/s41583-021-00497-x
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Homeobox genes and the specification of neuronal identity

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Cited by 76 publications
(59 citation statements)
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References 120 publications
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“…Our studies underscore the centrality of homeobox genes in controlling multiple aspects of neuronal identity, not only just in terms of conferring neuron-type-specific features as has been shown before, 13,50 but also in broadly defining what distinguishes non-neuronal from neuronal cells, a cell type that has gained the ability to communicate with others via a shared A complete list of strains and transgenes generated and used in this study is listed in the key resources table. A few of the strains were previously published, and/or obtained from the CGC, the National BioResource Project (NBRP, Japan) or the Transgeneome project, 52 as detailed in the key resources table.…”
Section: Discussionsupporting
confidence: 60%
“…Our studies underscore the centrality of homeobox genes in controlling multiple aspects of neuronal identity, not only just in terms of conferring neuron-type-specific features as has been shown before, 13,50 but also in broadly defining what distinguishes non-neuronal from neuronal cells, a cell type that has gained the ability to communicate with others via a shared A complete list of strains and transgenes generated and used in this study is listed in the key resources table. A few of the strains were previously published, and/or obtained from the CGC, the National BioResource Project (NBRP, Japan) or the Transgeneome project, 52 as detailed in the key resources table.…”
Section: Discussionsupporting
confidence: 60%
“…In this study, we describe the molecular codes for 26 LMC subclusters (16 and 10 for brachial and lumbar LMC MNs, respectively) that display unique combinatorial neuropeptide and TF expression profiles. Our findings support the terminal selector hypothesis that combinations of Hox/Lim homeodomain TFs might elicit a battery of subtype-specific genes, including ligands and receptors, cell adhesion molecules, and neurotransmitter-related genes, which would serve as regulators to robustly govern the fate and functions of subtypes 9496 .…”
Section: Discussionsupporting
confidence: 80%
“…The expression and activity of transcription factors (TFs) and their cognate enhancer elements are thought to be the earliest predictors of cell fate in many systems, including the CNS (Flitsch et al, 2020; Hobert, 2021). We observed that the level of expression of key TFs in RG progenitor cells at TD30 and TD60 was correlated with the abundances of neuron subtypes across samples, confirming that changes in neuronal proportion as measured by scRNA-seq reflected different patterning of progenitor cells.…”
Section: Resultsmentioning
confidence: 99%