BACKGROUND The topic of Complementary and Alternative Medicine (CAM) has been widely discussed in the scientific literature, including two highly-cited editorials that appeared in NEJM 1 and JAMA 2 in 1998. These articles agreed on a fundamental point, that is that the only accepted form of medicine should be based on evidence. Since then, many authors have tried to define what is CAM. A positive definition, describing CAM by what it is, rather than by what it is not, has been proposed by Ernst et al.: CAM is any "diagnosis, treatment and/or prevention which complements mainstream medicine by contributing to a common whole, by satisfying a demand not met by orthodoxy or by diversifying the conceptual frameworks of medicine". 3 Surveys from several European countries suggest a European-wide increase in the use of CAM during the last decades. 4 The prevalence of the use of CAM among adults in European countries, varies from 6-49% according to different studies 5 ˒ 6 ˒ 7 ˒ 8 ˒ 9 ˒ 10. Data for Italy is contradictory. According to a national survey, in 2005 at least 13.6% of population have used CAM during the last three years 11 , but a study conducted in Turin in 2008 estimates a prevalence of use of 43% in paediatric age during the previous year 12. This figure is consistent with other studies which have underlined that approximately 20% to 40% of healthy children seen in outpatient paediatric clinics 13 ˒ 14 ˒ 15 and more than 50% of children with chronic, recurrent, and incurable conditions use CAM, almost always in addition or conjunction with mainstream care 16. Children's health is not self-determined and depends on their parent's' choice. Considering the spread of the CAM use and the lack of recent studies estimating prevalence of CAM use in Italy , we believe in the importance of better understanding the amount and modality of CAM use in the paediatric population in order to identify any possible risk and health problem.