Homeostasis and Function of Regulatory T Cells in HIV/SIV Infection

Moreno‐Fernandez, Maria E.; Presicce, Pietro; Chougnet, Claire

doi:10.1128/jvi.00993-12

Cited by 82 publications

(76 citation statements)

References 96 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Alterations in the Treg compartment are observed during retroviral infections, including human immunodeficiency virus (HIV) (Angin et al, 2012;Apoil et al, 2005;Bandera et al, 2010;Bi et al, 2009;Kinter et al, 2007;Moreno-Fernandez et al, 2012;Schulze Zur Wiesch et al, 2011;Simonetta et al, 2012;Suchard et al, 2010), simian immunodeficiency virus (SIV) (Allers et al, 2010;Moreno-Fernandez et al, 2012), and LP-BM5 (Beilharz et al, 2004;Li & Green, 2006) and Friend (Dietze et al, 2011;Dittmer et al, 2004;Robertson et al, 2006;Zelinskyy et al, 2006Zelinskyy et al, , 2009 murine retroviral infections. HIV and SIV studies have reported increased (Bandera et al, 2010;Bi et al, 2009;Kinter et al, 2007;Moreno-Fernandez et al, 2012;Schulze Zur Wiesch et al, 2011;Suchard et al, 2010), decreased (Angin et al, 2012;Apoil et al, 2005;Simonetta et al, 2012) or no change (Chevalier et al, 2015) in the Treg compartment. In the aforementioned studies, variability in cell surface markers used to define Tregs, such as identification of human Tregs using only CD25 (Baecher-Allan et al, 2005), has led to difficulty in comparatively interpreting these results.…”

Section: Introductionmentioning

confidence: 99%

“…In the aforementioned studies, variability in cell surface markers used to define Tregs, such as identification of human Tregs using only CD25 (Baecher-Allan et al, 2005), has led to difficulty in comparatively interpreting these results. The role of Tregs during HIV infection remains unclear: do Tregs (i) suppress protective HIV-immune responses; (ii) decrease immune activation associated with HIV-pathogenesis; and/ or (iii) act as a reservoir for HIV infection (Chase et al, 2008;Chevalier & Weiss, 2013;Favre et al, 2009;Kinter et al, 2007;Moreno-Fernandez et al, 2012). Therefore, understanding the role of retrovirus-induced Tregs is critical to determine their potential as immunotherapeutic targets.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Reciprocal relationship of T regulatory cells and monocytic myeloid-derived suppressor cells in LP-BM5 murine retrovirus-induced immunodeficiency

O’Connor

Vella

Green

2016

Journal of General Virology

View full text Add to dashboard Cite

Immunomodulatory cellular subsets, including myeloid-derived suppressor cells (MDSCs) and T regulatory cells (Tregs), contribute to the immunosuppressive tumour microenvironment and are targets of immunotherapy, but their role in retroviral-associated immunosuppression is less well understood. Due to known crosstalk between Tregs and MDSCs in the tumour microenvironment, and also their hypothesized involvement during human immunodeficiency virus/simian immunodeficiency virus infection, studying the interplay between these immune cells during LP-BM5 retrovirus-induced murine AIDS is of interest. IL-10-producing FoxP3

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Reciprocal relationship of T regulatory cells and monocytic myeloid-derived suppressor cells in LP-BM5 murine retrovirus-induced immunodeficiency

O’Connor

Vella

Green

2016

Journal of General Virology

View full text Add to dashboard Cite

show abstract

“…+ T cell homeostasis and immune activation or specifically regulate the cellular immune response [26]. Recently, some authors postulated that they might play a role in iIR [14,27].…”

Section: Cd38mentioning

confidence: 99%

Association between discordant immunological response to highly active anti-retroviral therapy, regulatory T cell percentage, immune cell activation and very low-level viraemia in HIV-infected patients

Saison

Ferry

Demaret

et al. 2014

Clinical and Experimental Immunology

View full text Add to dashboard Cite

SummaryThe mechanisms sustaining the absence of complete immune recovery in HIV-infected patients upon long-term effective highly active anti-retroviral therapy (HAART) remain elusive. Immune activation, regulatory T cells (Tregs) or very low-level viraemia (VLLV) have been alternatively suspected, but rarely investigated simultaneously. We performed a cross-sectional study in HIV-infected aviraemic subjects (mean duration of HAART: 12 years) to concomitantly assess parameters associated independently with inadequate immunological response. Patients were classified as complete immunological responders (cIR, n = 48) and inadequate immunological responders (iIR, n = 39), depending on the CD4 + T cell count (> or < 500/mm 3 ). Clinical and virological data (including very low-level viraemia) were collected. In parallel, immunophenotyping of CD4 + lymphocytes, including Treg subsets, and CD8 + T cells was performed. Percentages of activated CD4 + T cells, Tregs, effector Tregs and terminal effector Tregs were found to be significantly elevated in iIR. Neither the percentage of activated CD8+ T cells nor VLLV were found to be associated with iIR. In the multivariate analysis, nadir of CD4 + T cell count and percentage of Tregs were the only two parameters associated independently with iIR [odds ratio (OR) = 2·339, P = 0·001, and OR = 0·803, P = 0·041]. We present here the largest study investigating simultaneously the immune response to long-term HAART, activation of CD4 + and CD8+ T cells, Treg percentages and very low-level viraemia. Causative interactions between Tregs and CD4 + T cells should now be explored prospectively in a large patients cohort.

show abstract

“…Conversely, some authors suggested that Tregs could be beneficial, particularly during early HIV infection when effector T cells are not yet activated, as these cells limit immune activation, thus controlling the availability of HIV targets as well as preventing immune-based pathologies [150,151]. The frequency of Tregs in peripheral blood mononuclear cells and gut-associated lymphoid tissue using CD4 + Foxp3 + and CD4 + Foxp3 + CD127 Low/-as markers was found to be higher in HIV patients than in controls [152]. Conversely, other authors reported that while HIV 'elite controllers' and uninfected individuals had similar Treg numbers and frequencies, the absolute numbers of Tregs declined in blood and gut-associated lymphoid tissue in patients with chronic progressive HIV-1 infection, but was largely normalized by HAART.…”

Section: Immunological Regulation In the Setting Of Hiv-1 Vaccinationmentioning

confidence: 99%

Enhancing Immunogenicity and Cross-Reactivity of HIV-1 Antigens by In Vivo Targeting to Dendritic Cells

et al. 2012

View full text Add to dashboard Cite

Current retroviral treatments have reduced AIDS to a chronic disease for most patients. However, given drug-related side effects, the emergence of drug-resistant strains and the persistence of viral replication, the development of alternative treatments is a pressing need. This review focuses on recent developments in HIV immunotherapy treatments, with particular emphasis on current vaccination strategies for optimizing the induction of an effective immune response by the recruitment of dendritic cells. In addition to cell-based therapies, targeted strategies aiming to deliver synthetic HIV peptides to dendritic cell-specific receptors in vivo will be discussed.

show abstract

Homeostasis and Function of Regulatory T Cells in HIV/SIV Infection

Cited by 82 publications

References 96 publications

Reciprocal relationship of T regulatory cells and monocytic myeloid-derived suppressor cells in LP-BM5 murine retrovirus-induced immunodeficiency

Reciprocal relationship of T regulatory cells and monocytic myeloid-derived suppressor cells in LP-BM5 murine retrovirus-induced immunodeficiency

Association between discordant immunological response to highly active anti-retroviral therapy, regulatory T cell percentage, immune cell activation and very low-level viraemia in HIV-infected patients

Enhancing Immunogenicity and Cross-Reactivity of HIV-1 Antigens by In Vivo Targeting to Dendritic Cells

Contact Info

Product

Resources

About