Homeostatic plasticity—a presynaptic perspective

Bridging Biological and Artificial Neural Networks with Emerging Neuromorphic Devices: Fundamentals, Progress, and Challenges

“…Although LTP and LTD act on opposite directions, Hebbian plasticity alone cannot maintain the homeostasis of neural circuits, because synapses undergo LTP are more likely to activate the postsynaptic neurons, thus undergoing further LTP rather than LTD. [240] Therefore, homeostatic plasticity is needed as a negative feedback to keep the normal activation level of neural circuits. [242] Several mechanisms have been proposed underlying homeostatic plasticity (Figure 10d) including but not restricted to synaptic scaling, shift of excitation and inhibition ratio, sliding threshold for LTP and LTD, and changes in neuronal excitability. [242] Several mechanisms have been proposed underlying homeostatic plasticity (Figure 10d) including but not restricted to synaptic scaling, shift of excitation and inhibition ratio, sliding threshold for LTP and LTD, and changes in neuronal excitability.…”

“…[241] Homeostatic plasticity often acts on the timescale of days, but more rapid homeostatic changes are also observed. [242] Several mechanisms have been proposed underlying homeostatic plasticity (Figure 10d) including but not restricted to synaptic scaling, shift of excitation and inhibition ratio, sliding threshold for LTP and LTD, and changes in neuronal excitability. [239,243] Experimentally, there has been attempt to demonstrate homeostatic plasticity using neuromorphic devices with global connectivity through electrolyte gating.…”

Maintenance of homeostatic plasticity at theDrosophilaneuromuscular synapse requires continuous IP3-directed signaling

“…Mechanistically, this increase in QC depends upon the successful execution of discrete 65 presynaptic events, such as increases in neuronal Ca 2+ influx and an increase in the size of the 66 readily releasable pool (RRP) of synaptic vesicles (Frank et al, 2006; Müller and Davis, 2012; 67 Müller et al, 2012). The field has termed this compensatory signaling process as presynaptic 68 homeostatic potentiation (PHP) (Delvendahl and Müller, 2019). Two factors that govern the ex-69 pression of PHP are the nature of the NMJ synaptic challenge and the amount of time elapsed 70 after presentation of the challenge.…”

Homeostatic control of Drosophila neuromuscular junction function

“…Given the progress in the field and the pace of discovery, we consider an update to be timely. This updated summary should be viewed as a companion to prior reviews Delvendahl & Müller, 2019;Wondolowski & Dickman, 2013;Frank, 2014aFrank, , 2014b. Parallel work on homeostatic plasticity continues apace at the mammalian NMJ (Homan & Meriney, 2018) and mammalian CNS preparations (Li, Park, Zhong, & Chen, 2019;Wefelmeyer, Puhl, & Burrone, 2016).…”

“…For daily living, key physiological parameters, such as body temperature or water/electrolyte balance, are under homeostatic control. In the nervous system, metazoans have evolved homeostatic mechanisms to actively stabilize neuronal excitability, chemical synaptic transmission, and neural circuit function (Delvendahl & Müller, 2019;Marder & Goaillard, 2006;Pozo & Goda, 2010;Turrigiano, 2008). A marvelous diversity of homeostatic processes controlling neural function has been identified: Homeostatic mechanisms compensate for activity manipulations of single neurons (Burrone, O'Byrne, & Murthy, 2002;Murthy, Schikorski, Stevens, & Zhu, 2001) or neural networks in vitro (Hartman, Pal, Burrone, & Murthy, 2006;O'Brien et al, 1998;Turrigiano, Leslie, Desai, Rutherford, & Nelson, 1998) and in vivo (Desai, Cudmore, Nelson, & Turrigiano, 2002;Maffei & Turrigiano, 2008).…”