2023
DOI: 10.7554/elife.92095.1
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Homeostatic regulation of REM sleep by the preoptic area of the hypothalamus

John Maurer,
Alex Lin,
Xi Jin
et al.

Abstract: Rapid-eye-movement sleep (REMs) is characterized by activated electroencephalogram (EEG) and muscle atonia, accompanied by vivid dreams. REMs is homeostatically regulated, ensuring that any loss of REMs is compensated by a subsequent increase in its amount. However, the neural mechanisms underlying the homeostatic control of REMs are largely unknown. Here, we show that GABAergic neurons in the preoptic area of the hypothalamus projecting to the tuberomammillary nucleus (POA GAD2 →TMN neurons) are crucial for t… Show more

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