Homeostatic regulation of the aryl hydrocarbon receptor-cytochrome P450 1a axis by Scutellaria baicalensis-Coptis chinensis herb pair and its main constituents

Song, Mengmeng; Sheng, Xianjie; Zhang, Jianrong; Li, Xinru; Dai, Qianyun; Chen, Yan; An, Kang

doi:10.1016/j.jep.2022.115545

Cited by 14 publications

(1 citation statement)

References 35 publications

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“…and Sophora flavescens Ait. (CC-SF) is a common herbal couple in many traditional Chinese medicines applied to various diseases, including diarrhea, metabolic disorders, and colorectal cancer [1,2]. In recent years, there are extensive studies on CC-SF in treating ulcerative colitis (UC) [3,4].…”

Section: Introductionmentioning

confidence: 99%

The colonic metabolism differences of main alkaloids in normal and colitis mice treated with Coptis chinensis Franch. and Sophora flavescens Ait. herbal pair using liquid chromatography‐high resolution mass spectrometry method combined with chemometrics

Li,

Chen,

Zhang

et al. 2023

J of Separation Science

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Coptis chinensis Franch. and Sophora flavescens Ait. is a herbal pair frequently used in treating ulcerative colitis. However, the bio-disposition profile of the major components in the inflamed gut remains unclear, which is essential to understand the pharmacological material basis of this herb pair. Here we established an integral quantitative and chemometric method to deduce the colonic metabolism differences of this herbal pair in normal and colitis mice. With this LC-MS method, a total of 41 components have been found in the Coptis chinensis Franch. and Sophora flavescens Ait. extract, and 28 metabolites were found in the colon after oral administration. Alkaloid and its phase I metabolites were the main components in the colon of normal and colitis mice. The results of principal component analysis at 6 h after oral administration showed significant colonic metabolism differences between normal and colitis mice. Heamap results showed that colitis induced significant changes in the colonic bio-disposition of this herbal pair extract. In particular, in the context of colitis, the phase I metabolism of berberine, coptisine, jatrorrhizine, palmatine,and epiberberine has been inhibited. These results may provide a basis for Article Related Abbreviations: CC-SF, Coptis chinensis Franch. and Sophora flavescens Ait.; DSS, dextran sulfate sodium salt; PCA, principal component analysis; UC, ulcerative colitis.Qin Li and Zihan Chen contributed equally to this work.

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Section: Introductionmentioning

confidence: 99%

The colonic metabolism differences of main alkaloids in normal and colitis mice treated with Coptis chinensis Franch. and Sophora flavescens Ait. herbal pair using liquid chromatography‐high resolution mass spectrometry method combined with chemometrics

Li,

Chen,

Zhang

et al. 2023

J of Separation Science

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Review on the pharmacological effects and pharmacokinetics of scutellarein

Lai,

2024

Archiv der Pharmazie

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Scutellarein is a flavonoid from Scutellaria baicalensis Georgi that has been shown to have a variety of pharmacological activities. This review aims to summarize the pharmacological and pharmacokinetic studies on scutellarein and provide useful information for relevant scholars. Pharmacological studies indicate that scutellarein possesses a diverse range of pharmacological properties, including but not limited to anti‐inflammatory, antioxidant, antiviral, neuroprotective, hypoglycemic, hypolipidemic, anticancer, and cardiovascular protective effects. Further investigation reveals that the pharmacological effects of scutellarein are driven by multiple mechanisms. These mechanisms encompass the scavenging of free radicals, inhibition of the activation of inflammatory signaling pathways and expression of inflammatory mediators, inhibition of the activity of crucial viral proteins, suppression of gluconeogenesis, amelioration of insulin resistance, improvement of cerebral ischemia‐reperfusion injury, induction of apoptosis in cancer cells, and prevention of myocardial hypertrophy, among others. In summary, these pharmacological studies suggest that scutellarein holds promise for the treatment of various diseases. It is imperative to conduct clinical studies to further elucidate the therapeutic effects of scutellarein. However, it is worth noting that studies on the pharmacokinetics reveal an inhibitory effect of scutellarein on uridine 5′‐diphosphate glucuronide transferases and cytochrome P450 enzymes, potentially posing safety risks.

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Effects of Berberis vulgaris, and its active constituent berberine on cytochrome P450: a review

Bathaei,

Imenshahidi,

Hosseinzadeh

2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Homeostatic regulation of the aryl hydrocarbon receptor-cytochrome P450 1a axis by Scutellaria baicalensis-Coptis chinensis herb pair and its main constituents

Cited by 14 publications

References 35 publications

The colonic metabolism differences of main alkaloids in normal and colitis mice treated with Coptis chinensis Franch. and Sophora flavescens Ait. herbal pair using liquid chromatography‐high resolution mass spectrometry method combined with chemometrics

The colonic metabolism differences of main alkaloids in normal and colitis mice treated with Coptis chinensis Franch. and Sophora flavescens Ait. herbal pair using liquid chromatography‐high resolution mass spectrometry method combined with chemometrics

Review on the pharmacological effects and pharmacokinetics of scutellarein

Effects of Berberis vulgaris, and its active constituent berberine on cytochrome P450: a review

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