Homo- and heteroleptic trimethoxy terpyridine–Cu(<scp>ii</scp>) complexes: synthesis, characterization, DNA/BSA binding, DNA cleavage and cytotoxicity studies

Jain, Surbhi; Bhar, Kishalay; Kumar, Sandeep; Bandyopadhyaya, Shreetama; Tapryal, Suman; Mandal, Chandi C.; Sharma, A.

doi:10.1039/d0dt00209g

Cited by 33 publications

(23 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The decrease in fluorescence intensity of EtBr and ctDNA at 617 nm (Figure c) was examined by estimating the binding constant value using the Stern–Volmer equation where I 0 and I are emission intensities measured at the emission wavelength of 617 nm for [EtBr + ctDNA] and [EtBr + ctDNA + C-dots], respectively.…”

Section: Resultsmentioning

confidence: 99%

Mushroom-Derived Carbon Dots for Toxic Metal Ion Detection and as Antibacterial and Anticancer Agents

Thulasinathan

Murugan

Sengottuvelan

et al. 2020

ACS Appl. Nano Mater.

180

View full text Add to dashboard Cite

Although carbon nanoparticles or quantum dots (C-dots) have been studied extensively for a variety of applications (e.g., photocatalysis, metal ion sensing, antibacterial, cell labeling), a greener synthetic method is highly indispensable. Herein, we report a facile one-step hydrothermal carbonization approach for the synthesis of fluorescent blue/green C-dots using oyster mushroom (Pleurotus species). First, we demonstrate the application of these C-dots as a colorimetric sensor for toxic metal ions detection such as heavy metal Pb2+ ions with the limit of detection (LOD) and limit of quantification (LOQ) of 58.63 μM and 177.69 μM, respectively. Second, we show the application of C-dots as a promising fluorescent probe for DNA recognition through the electrostatic intercalative interaction between ctDNA and C-dots. Third, we demonstrate the efficient antibacterial activity of C-dots against three bacterial strains (Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa). Finally, the anticancer activity of C-dots against MDA-MB-231 breast cancer cells is demonstrated.

show abstract

Section: Resultsmentioning

confidence: 99%

Mushroom-Derived Carbon Dots for Toxic Metal Ion Detection and as Antibacterial and Anticancer Agents

Thulasinathan

Murugan

Sengottuvelan

et al. 2020

ACS Appl. Nano Mater.

180

View full text Add to dashboard Cite

show abstract

“… [214] 48-Cu AGE,pET-28b, e OxC * Cytotoxicity activity. [66] 49-Ru 4 pCMUT, AGE, PC *Photocytotoxicity activity: MTT assay. Cellular ROS generation.…”

Section: Amss In Pharma Studiesmentioning

confidence: 99%

“…Accordingly, these actively ongoing techniques are categorized as follow: i) Preparation of multinuclear complexes wherein the metal cores cooperate to provides an efficient active binding site for biomolecules [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] . ii) Variation of the first coordination sphere towards synthesis of homoleptic and hetroleptic complexes [66] , [67] , [68] , [69] , [70] , [71] . iii) Modification of the second coordination sphere via addition of the functional groups or by using the supramolecular hosts such as cyclodextrins (CDs) [56] , [57] , [72] , [73] , [74] , [75] , [76] , [77] , [78] , [79] , [80] , [81] , [82] , [83] .…”

Section: Introductionmentioning

confidence: 99%

Nuclease-like metalloscissors: Biomimetic candidates for cancer and bacterial and viral infections therapy

Anjomshoa

Amirheidari

2022

Coordination Chemistry Reviews

View full text Add to dashboard Cite

Despite the extensive and rapid discovery of modern drugs for treatment of cancer, microbial infections, and viral illnesses; these diseases are still among major global health concerns. To take inspiration from natural nucleases and also the therapeutic potential of metallopeptide antibiotics such as the bleomycin family, artificial metallonucleases with the ability of promoting DNA/RNA cleavage and eventually affecting cellular biological processes can be introduced as a new class of therapeutic candidates. Metal complexes can be considered as one of the main categories of artificial metalloscissors, which can prompt nucleic acid strand scission. Accordingly, biologists, inorganic chemists, and medicinal inorganic chemists worldwide have been designing, synthesizing and evaluating the biological properties of metal complexes as artificial metalloscissors. In this review, we try to highlight the recent studies conducted on the nuclease-like metalloscissors and their potential therapeutic applications. Under the light of the concurrent Covid-19 pandemic, the human need for new therapeutics was highlighted much more than ever before. The nuclease-like metalloscissors with the potential of RNA cleavage of invading viral pathogens hence deserve prime attention.

show abstract

“…The BSA protein is sub-divided into three parts for the drugs to bind, out of which one is located at the sub-domain IIA which contains the tryptophan and tyrosine residues while the other two is located at IIIA sub-domain which contains only the tyrosine residue. [86] Further, the complex and BSA when interact, it results in the changes of these protein residues and the spectra (Figure 8) shows significant quenching of fluorescence which is indicative of strong binding occurring along with either conformational changes, decreasing hydrophobicity or increasing the polarity of the BSA molecule. [73,85,87,88] Since a clear involvement of tryptophan residues can be seen in the spectra at Δλ = 60 nm, one can conclude that sub-domain IIA will probably be the binding site of the protein.…”

Section: Syntheses and Characterization Of Ruthenium Pincer Complexes...mentioning

confidence: 99%

Design and Syntheses of Ruthenium ENE (E = S, Se) Pincer Complexes: A Versatile System for Catalytic and Biological Applications

Bhatt

Meena

Kumar

et al. 2022

Chemistry An Asian Journal

Self Cite

View full text Add to dashboard Cite

This report describes the synthesis of two ruthenium(II) ENE pincer complexes (E = S, C1 and E = Se, C2) by the reaction of bis(2‐(phenylchalcogenyl)ethyl)amine (L1, L2) with RuCl2(PPh3)3. The complexes were characterized with the help of 1H and 13C{1H} NMR, FTIR, HRMS, cyclic voltammetry and elemental analysis techniques. The structure and bonding mode of ligand with ruthenium in C2 was established with the help of single crystal X‐ray diffraction. The complex showed distorted octahedral geometry with two chlorine atoms trans to each other. The Ru−Se bond distances (Å) are 2.4564(3)‐2.4630(3), Ru−N distance is 2.181(2), Ru−P distance is 2.2999(6), and Ru−Cl distances are 2.4078(6)‐2.4314(6). The complexes showed good to excellent catalytic activity for the N‐alkylation of o‐phenylenediamine with benzyl alcohol derivatives to synthesize 1,2‐disubstituted benzimidazole derivatives. The complexes were also found to be efficient for aerobic oxidation of benzyl alcohols to corresponding aldehydes which are precursors to the bisimines generated in situ during the synthesis of 1,2‐disubstituted benzimidazole derivatives. Complex C2 where selenium is coordinated with ruthenium was found to be more efficient as compared to sulfur coordinated ruthenium complex C1. Since ruthenium complexes are getting increasing attention for developing new anticancer agents, the preliminary studies like binding behavior of both the complexes towards CT‐DNA were studied by competitive binding with ethidium bromide (EthBr) using emission spectroscopy. In addition, the interactions of C1−C2 were also studied with bovine serum albumin (BSA) using steady state fluorescence quenching and synchronous fluorescence studies. A good stability of Ru(II) state was observed by cyclic voltammetric studies of C1−C2. Overall these molecules are good examples of bio‐organometallic systems for catalytic and biological applications.

show abstract

Homo- and heteroleptic trimethoxy terpyridine–Cu(ii) complexes: synthesis, characterization, DNA/BSA binding, DNA cleavage and cytotoxicity studies

Abstract: In the current study, four novel mononuclear Cu(ii) complexes with terpyridine (L) and different co-ligands (phen, bipy, and imd) were synthesized and characterized in detail, where L is 4′-(3,4,5-trimethoxyphenyl)-2,2′:6′,2′′-terpyridine.

Cited by 33 publications

References 59 publications

Mushroom-Derived Carbon Dots for Toxic Metal Ion Detection and as Antibacterial and Anticancer Agents

Mushroom-Derived Carbon Dots for Toxic Metal Ion Detection and as Antibacterial and Anticancer Agents

Nuclease-like metalloscissors: Biomimetic candidates for cancer and bacterial and viral infections therapy

Design and Syntheses of Ruthenium ENE (E = S, Se) Pincer Complexes: A Versatile System for Catalytic and Biological Applications

Contact Info

Product

Resources

About