Homochiral Metal–Organic Framework [Ni(S-mal)(bpy)]n Used for the Separation of Racemic Compounds by High Performance Liquid Chromatography

Xu, Nayan; Yuan, Baoyan; Hu, Cong; Yu, Yunyan; Fu, Nan; Zhang, Junhui

doi:10.1134/s1061934821060149

Cited by 11 publications

(1 citation statement)

References 20 publications

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“…In order to improve the diversity and efficiency of separation, porous materials have been developed as the CSP due to their intriguing structural merits, such as the tunable pore size, large specific surface area, and flexible modification . To date, various emerging materials including carbon nanomaterials, , mesoporous silica, − metal organic frameworks, − and covalent organic frameworks (COFs) , have been used to construct the CSP for enantioseparation.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Chiral Recognition Abilities of Cyclodextrin Covalent Organic Frameworks via Chiral/Achiral Functional Modification

Qiu

et al. 2022

ACS Appl. Mater. Interfaces

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β-Cyclodextrin covalent organic frameworks (β-CD COFs) show great potential in enantioseparation due to their uniformly distributed chiral recognition sites and good chemical stability. The hydroxyl and amino groups of β-CD COFs enable facile post-modification to introduce the desired functionality into the frameworks. In this study, we perform post-modification of β-CD COF BPDA with 1,4-butane sultone and [(3R,4R)-4-acetyloxy-2,5-dioxooxolan-3-yl] acetate to construct two kinds of novel functional β-CD COFs. The capillary columns prepared with these two functional β-CD COFs separated chiral dihydropyridines and fluoroquinolones with excellent selectivity and repeatability in capillary electrochromatography, while β-CD COF BPDA -modified capillary columns did not present the chiral recognition ability for these drugs. The mechanism of chiral recognition and the enhanced enantioselectivity of functional β-CD COFs were further demonstrated by molecular docking simulation. The divergent chiral separation performances of β-CD COFs suggest that the introduction of functional groups enables the modification of β-CD COF properties and tuning of its chiral recognition abilities for the diversity of enantioseparation.

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