In this paper, we study the existence of infinitely many homoclinic solutions for the second‐order self‐adjoint discrete Hamiltonian system Δ2uMathClass-open(nMathClass-bin−1MathClass-close)MathClass-bin−LMathClass-open(nMathClass-close)uMathClass-open(nMathClass-close)MathClass-bin+MathClass-rel∇WMathClass-open(nMathClass-punc,uMathClass-open(nMathClass-close)MathClass-close)MathClass-rel=0, where nMathClass-rel∈double-struckZ, uMathClass-rel∈RN and L:ℤ→ℝN×N are unnecessarily positive definites for all nMathClass-rel∈double-struckZ. By using the variant fountain theorem, we obtain an existence criterion to guarantee that the aforementioned system has infinitely many homoclinic solutions under the assumption that W(n,x) is asymptotically quadratic as | x | → + ∞ . Copyright © 2013 John Wiley & Sons, Ltd.