Homocysteine and C-reactive Protein Levels in Women with Polycystic Ovary Syndrome

Abstract

Objectives: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in infertile women characterized by both reproductive and metabolic dysfunctions of different degrees. Furthermore, it has been associated with increased cardiovascular disease (CVD) risk and related long-term health sequela. The aim of this study is to evaluate serum homocysteine (Hcy) and C-reactive protein (CRP) levels in women with PCOS and to evaluate their relationship with clinical and laboratory parameters in women with PCOS. Materials and Methods: The prospective single-center study included 45 women with PCOS (study group) and 41 control subjects. Demographic variables and Hcy, CRP, fasting blood glucose, insulin, follicle-stimulating hormone, luteinizing hormone, estradiol, total and free testosterone, dehydroepiandrosterone sulfate, thyroid-stimulating hormone levels, and lipid profiles of the subjects were recorded. homeostatic model assessment for insulin resistance (HOMA-IR) indexes were calculated. Results: Fasting plasma glucose, insulin, HOMA-IR, free and total testosterone levels, and clinical hirsutism were significantly higher in the study group. There was no statistically significant difference in lipid profile between groups. Hcy and CRP levels were higher in the study group, which was not statistically significantly different ( P > 0.05). Conclusion: Some of the parameters that are correlated with CVD risk were found to be higher in women with PCOS, although the difference for Hcy and CRP did not reach statistical significance. However, the current study reveals that the CVD risk associated with PCOS deserves more comprehensive prospective studies with long-term outcomes.

Non-causal relationship of polycystic ovarian syndrome with homocysteine and B vitamins: evidence from a two-sample Mendelian randomization

“…Our investigation found no genetic causal connection between elevated genetically predicted plasma Hcy levels and the incidence of PCOS. This conclusion contrasts with several observational studies that have reported increased plasma Hcy levels in women with PCOS ( 18 , 27 , 45 ). Homocysteine thiolactone, an active metabolite of Hcy, has been demonstrated to disrupt tyrosine phosphorylation in the insulin receptor β-subunit and related substrates, hindering phosphatidylinositol 3-kinase activity and subsequently reducing insulin-mediated glycogen synthesis, a key factor in the development of insulin resistance ( 46 ).…”

The Associations Between Alanine Aminotransferase and Other Biochemical Parameters in Lean PCOS

“…Simultaneously, homocysteine in the lean PCOS was also significantly higher than the healthy controls; this is beneficial in corroborating the higher risk of cardiovascular disease in PCOS for the people with higher homocysteine incline to get microthrombus in the vessels [ 23 ], and considered to be an independent risk factor for atherogenic and thrombotic components of various systems [ 24 ]. Besides, elevated homocysteine level is also tightly linked with fatty liver and chronic kidney disease [ 25 , 26 ], while others [ 27 ] observed the opposite; they [ 27 , 28 ] supposed the homocysteine levels are more higher in severe liver disease, but not in the mild one.…”

The Role of Oxidative Stress on Cardiovascular Properties of the Androgen- Induced PCOS in Female Rats

“…It is a renowned infection marker, but it can also be used to monitor low-grade chronic inflammation and anticipate vascular events. Other research has found that PCOS have higher CRP, indicating that the illness is chronically inflammatory [40,41].…”