Homocysteine and Cognitive Function in a Population‐Based Study of Older Adults

Schafer, Jyme H.; Glass, Thomas A.; Bolla, Karen I.; Mintz, Margaret; Jedlicka, Anne; Schwartz, Brian S.

doi:10.1111/j.1532-5415.2005.53153.x

Cited by 110 publications

(88 citation statements)

References 36 publications

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“…The APOE ε4 cohort (2/4, 3/4, 4/4) represented 25.8% of our sample. This representation is within the range (24-30%) reported in other studies of APOE [16,29,30]. Mean cognitive scores for non-diabetic and diabetic individuals with adjustment for variables in the basic and basic+RF+CVD models are shown in Table 3.…”

Section: Resultssupporting

confidence: 75%

Presence of the APOE ε4 allele modifies the relationship between type 2 diabetes and cognitive performance: the Maine–Syracuse Study

et al. 2009

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Aims/hypothesis The primary aim of this study was to determine whether the presence of one or more APOE ε4 alleles modifies the association between diabetes (defined by glucose ≥7 mmol/l or treatment) and cognitive function. Methods Diabetic status and APOE genotype interactions were assessed cross-sectionally for 826 communitydwelling, stroke-free, non-demented individuals (526 nondiabetic non-APOE ε4 carriers, 174 non-diabetic APOE ε4 carriers, 87 diabetic APOE ε4 non-carriers, 39 diabetic APOE ε4 carriers) ranging in age from 50 to 98 years. Cognitive function was assessed using the Mini-Mental State Examination (MMSE), the similarities subtest from the Wechsler Adult Intelligence Scale, and four composite scores derived from 17 additional neuropsychological tests. Multiple linear regression analyses were employed to relate diabetes and APOE genotype to cognitive performance and to examine the interaction between these two risk factors as they relate to cognitive performance. Multiple cardiovascular disease risk factors were statistically controlled. Results With adjustment for age, education, sex, race/ ethnicity and APOE genotype, performance level was lower for the diabetic than for the non-diabetic group for the MMSE, the similarities subtest and each of the cognitive composites with the exception of the verbal memory composite. Interactions (p<0.05) between diabetes and APOE genotype were found for all but the visual-spatial memory/organisation composite. The negative association between diabetes and cognitive performance was of a higher magnitude for individuals who carry one or more APOE ε4 alleles. Results were similar with additional adjustment for cardiovascular disease and associated risk factors. Conclusions/interpretation The presence of one or more APOE ε4 alleles modifies the association between diabetes and cognitive function.

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Section: Resultssupporting

confidence: 75%

Presence of the APOE ε4 allele modifies the relationship between type 2 diabetes and cognitive performance: the Maine–Syracuse Study

et al. 2009

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“…Homocysteine has been linked to mild cognitive impairment and other aspects of cognitive decline [36,41]. Initially, high plasma total homocysteine was linked to atherothrombotic disease [42].…”

Section: Homocysteinementioning

confidence: 99%

Complex Antioxidant Blend Improves Memory in Community-Dwelling Seniors

Summers

Martin

Cunningham

et al. 2010

JAD

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Abstract.One hundred thirteen community dwelling subjects between the ages of 50 and 75 without dementia were recruited. A blind administrator randomly assigned 54 subjects to placebo and 59 to active treatment groups. The active treatment consisted of four months treatment with a complex antioxidant blend. Placebo treatment was an identical gel and bottle administered for four months. Forty-eight active subjects and 38 placebo subjects completed the study. Memory testing with a 50 part paired association test and a 20-word immediate recall test were significantly improved, p = 0.015 and p = 0.005 respectively. A secondary study of serum homocysteine was completed in 25 active treatment subjects and 17 placebo subjects. Significant reduction in serum homocysteine levels was seen in the active treatment subjects (p = 0.005). A complex antioxidant blend taken over four months improves performance on two difficult memory tests in community dwelling elderly subjects. Furthermore, the antioxidant significantly reduced the serum homocysteine level in treatment group.

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“…Other studies have demonstrated that high plasma levels of homocysteine are associated with poorer neurobehavioral test performance in the elderly; subjects with HyHcy perform worst in all cognitive domains but were strongest in the domains related to simple motor and psychomotor speed and eye-hand coordination [25]; on the other hand, controversial results have been obtained on a possible reduction in spatial learning and other cognitive tasks in rats with diet-induced HyHcy [26,27].…”

Section: Discussionmentioning

confidence: 87%

Postural Control in Patients After a Recent Vestibular Neuritis with Hyperhomocysteinemia

Raponi¹,

Teggi

Gatti

et al. 2012

Indian J Otolaryngol Head Neck Surg

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To assess the possible role of hyperhomocysteinemia (HyHcy) in delaying recovery after acute vestibular neuritis. In our retrospective study, 90 subjects were evaluated within 7 days from the beginning of an acute vertigo. All subjects had high plasma levels of homocysteine (Hcy). 46 patients were treated with homocysteine lowering therapy and betahistine for 1 month, while 44 subjects received only betahistine. Subjective symptoms were evaluated with the Dizziness Handicap Inventory (DHI) questionnaire, administered 7 days after the beginning of vertigo and again after 1 month. Moreover, postural control performed at 1 month' control was studied with static stabilometry in a subgroup of 21 non-treated and 20 treated patients. DHI total score decreased significantly more in the subgroup of subjects treated with homocysteine lowering therapy. Moreover, posturographic data were significantly increased in non-treated compared with treated subjects. Our data support the possibility of a role of HyHcy in preventing recovery after a recent vestibular neuritis. A microvascular disorder or the neurotoxic effect of HyHcy have been considered as possible causal factors. Although not conclusive, our data are not inconsistent with the hypothesis of a poorer adaptation in patients with untreated HyHcy.

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Homocysteine and Cognitive Function in a Population‐Based Study of Older Adults

Abstract: Higher homocysteine levels were associated with worse function across a broad range of cognitive domains, and the magnitude of the associations was large. The data suggest that homocysteine may be a potentially important modifiable cause of cognitive dysfunction.

Cited by 110 publications

References 36 publications

Presence of the APOE ε4 allele modifies the relationship between type 2 diabetes and cognitive performance: the Maine–Syracuse Study

Presence of the APOE ε4 allele modifies the relationship between type 2 diabetes and cognitive performance: the Maine–Syracuse Study

Complex Antioxidant Blend Improves Memory in Community-Dwelling Seniors

Postural Control in Patients After a Recent Vestibular Neuritis with Hyperhomocysteinemia

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