2006
DOI: 10.1097/00002480-200603000-00103
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Homocysteine and Malondialdehyde as Predictors of Restenosis Following Percutaneous Coronary Intervention

Abstract: Restenosis is one of the major adverse outcomes of Percutaneous CoronaryIntervention (PCI). Previous studies have shown conflicting reports for homocysteine as a predictor of restenosis following PCI. The conflicting reports may be due to oxidative factors (stimulation of polymorphonuclear leukocyte [PMNL]-induced reactive oxygen species generation, xanthine-xanthine oxidase, and arachidonic acid metabolism) other than homocysteine which could cause endothelial cell dysfunction leading to restenosis.Malondiald… Show more

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Cited by 3 publications
(3 citation statements)
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References 355 publications
(441 reference statements)
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“…13 Therefore, the objective of measuring MDA is that it serves as an indirect biomarker of ROS activity. 14 Collectively, endothelial injury, sRAGE, AGE, and ROS appear predictive of restenosis. In this pilot study, we hypothesize that post-PCI ISR is associated with low serum levels of sRAGE, high serum levels of AGE, and high AGE/sRAGE ratios.…”
mentioning
confidence: 99%
“…13 Therefore, the objective of measuring MDA is that it serves as an indirect biomarker of ROS activity. 14 Collectively, endothelial injury, sRAGE, AGE, and ROS appear predictive of restenosis. In this pilot study, we hypothesize that post-PCI ISR is associated with low serum levels of sRAGE, high serum levels of AGE, and high AGE/sRAGE ratios.…”
mentioning
confidence: 99%
“…Increased levels of oxygen radicals have been reported in patients with ACS. 46,47 The cellular membrane damage from oxygen radicals 24,25,31 may result in the release of various biomarkers including cTnI. A negative correlation between sRAGE and cTnI suggests that the severity of cardiac damage varies inversely with the levels of sRAGE.…”
Section: Discussionmentioning
confidence: 99%
“…Diabetes is a significant risk factor for atherosclerosis; the diabetic state promotes oxidative stress mediated by reactive oxygen species, these consume NO and lead to endothelial dysfunction (Libby, Ridker and Maseri, 2002). Hyperglycemia in diabetics may induce dysfunctional endothelium which is involved in the genesis of atherosclerosis (McNair, 2006). Atherosclerosis is considered to be an inflammatory process triggered by response to injury and oxidative stress.…”
Section: Serum Homocysteine and Hyperglycemiamentioning
confidence: 99%