Homocysteine and Mobility in Older Adults

Rolita, Lydia; Wang, Cuiling; Lipton, Richard B.; Derby, Carol A.

doi:10.1111/j.1532-5415.2010.02718.x

Cited by 25 publications

(22 citation statements)

References 33 publications

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“…For vitamin B12 in women, and for homocysteine and vitamin B12 in men, the observed associations were less consistent. This study partly confirms the results of five earlier studies that observed an association between homocysteine and physical performance in the general older population (Kado et al, 2002;Soumare et al, 2006;Gerdhem et al, 2007;Kuo et al, 2007;Rolita et al, 2010). In addition, this study confirms the presence of a longitudinal association between homocysteine and physical performance of two earlier studies (Kado et al, 2002;Rolita et al, 2010).…”

Section: Discussionsupporting

confidence: 82%

“…This study partly confirms the results of five earlier studies that observed an association between homocysteine and physical performance in the general older population (Kado et al, 2002;Soumare et al, 2006;Gerdhem et al, 2007;Kuo et al, 2007;Rolita et al, 2010). In addition, this study confirms the presence of a longitudinal association between homocysteine and physical performance of two earlier studies (Kado et al, 2002;Rolita et al, 2010). In the first three studies, the association between homocysteine and physical performance was observed in a combined sample of men and women (Kado et al, 2002;Soumare et al, 2006;Kuo et al, 2007).…”

Section: Discussionsupporting

confidence: 81%

“…The results of our study extend the findings of Kado et al (2002) by identifying sex as an effect modifier, and by studying men and women with a much wider age range (65-88 years in our study versus 70-79 years in the study by Kado et al (2002). However, in contrast to our results, sex was not identified as an effect modifier in the study by Rolita et al (2010).…”

Section: Discussioncontrasting

confidence: 54%

“…Five previous studies observed associations between elevated homocysteine and lower physical performance in the general older population (Kado et al, 2002;Soumare et al, 2006;Gerdhem et al, 2007;Kuo et al, 2007;Rolita et al, 2010). Only two of those studies examined the longitudinal association (Kado et al, 2002;Rolita et al, 2010), showing that elevated homocysteine increased the risk of physical decline. These studies were relatively small (n ¼ 499 and n ¼ 574, respectively), and the first study was limited to highly functioning men and women with a narrow age range (70-79 years).…”

Section: Introductionmentioning

confidence: 99%

“…Homocysteine and B vitamins have been associated with cardiovascular disease (especially stroke) (Homocysteine Studies Collaboration, 2002;Ntaios et al, 2009), cognitive decline and dementia (Haan et al, 2007;Ravaglia et al, 2007;Smith, 2008), fractures (McLean et al, 2004;van Meurs et al, 2004;Sato et al, 2005) and mortality (Connolly et al, 2009;de Ruijter et al, 2009;Zhang et al, 2010). In addition, elevated homocysteine has been associated with lower physical performance (Kado et al, 2002;Soumare et al, 2006;Gerdhem et al, 2007;Kuo et al, 2007;McDermott et al, 2007;Rolita et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Cross-sectional and longitudinal association between homocysteine, vitamin B12 and physical performance in older persons

et al. 2011

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Background/Objectives: Decreases in physical performance are associated with multiple negative health outcomes. The objective of this study was to examine whether high plasma homocysteine and low serum vitamin B12 are independent risk factors for lower physical performance, both cross-sectionally and longitudinally. Subjects/Methods: This study was performed in persons aged X65 years of the LASA (Longitudinal Aging Study Amsterdam), an ongoing cohort study. Blood was collected in 1995/1996 (n ¼ 1352). Physical performance was assessed in 1995/1996 and in 1998/1999 using three tests: the walking test, the chair stands test and the tandem stand (n ¼ 901-1155). Results: After adjustment for confounding, women in the highest quartile of homocysteine had a significantly lower physical performance than did those in the lowest quartile in the cross-sectional analyses (b ¼ À0.93, s.e. ¼ 0.34, Po0.01). This association was borderline statistically significant in the longitudinal analyses (b ¼ À0.69, s.e. ¼ 0.35, P ¼ 0.05). After additional adjustment for serum vitamin B12, both associations were statistically significant (Po0.05). For vitamin B12 in women, and for homocysteine and vitamin B12 in men, the observed associations were less consistent. Conclusions: High plasma homocysteine is an independent risk factor for lower physical performance in older women. The association between vitamin B12 and physical performance is less clear.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 81%

Section: Discussioncontrasting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cross-sectional and longitudinal association between homocysteine, vitamin B12 and physical performance in older persons

et al. 2011

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A Randomized Controlled Trial to Examine the Effect of 2-Year Vitamin B12 and Folic Acid Supplementation on Physical Performance, Strength, and Falling: Additional Findings from the B-PROOF Study

et al. 2015

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Elevated homocysteine concentrations are associated with a decline in physical function in elderly persons. Homocysteine-lowering therapy may slow down this decline. This study aimed to examine the effect of a 2-year intervention of vitamin B12 and folic acid supplementation on physical performance, handgrip strength, and risk of falling in elderly subjects in a double-blind, randomized placebo-controlled trial. Participants aged ≥65 years with elevated plasma homocysteine concentrations [12–50 µmol/L (n = 2919)] were randomly assigned to daily supplementation of 500 µg vitamin B12, 400 µg folic acid, and 600 IU vitamin D3, or to placebo with 600 IU vitamin D3. Physical performance (range 0–12) and handgrip strength (kg) were measured at baseline and after 2 years. Falls were reported prospectively on a research calendar. Intention-to-treat (primary) and per-protocol (secondary) analyses were performed. Physical performance level and handgrip strength significantly decreased during the follow-up period, but this decline did not differ between groups. Moreover, time to first fall was not significantly different (HR: 1.0, 95 % CI 0.9–1.2). Secondary analyses on a per-protocol base identified an interaction effect with age on physical performance. In addition, the treatment was associated with higher follow-up scores on the walking test (cumulative OR: 1.3, 95 % CI 1.1–1.5). Two-year supplementation of vitamin B12 and folic acid was neither effective in reducing the age-related decline in physical performance and handgrip strength, nor in the prevention of falling in elderly persons. Despite the overall null-effect, the results provide indications for a positive effect of the intervention on gait, as well as on physical performance among compliant persons >80 years. These effects should be further tested in future studies.

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Vitamin B12, Folic Acid, and Bone

Swart

Schoor

Lips

2013

Curr Osteoporos Rep

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Vitamin B12 and folic acid deficiency are associated with a higher serum concentration of homocysteine. A high serum homocysteine is a risk factor for fractures. Both vitamins play a role in the remethylation of homocysteine to methionine. The pathophysiology from a high serum homocysteine to fractures is not completely clear, but might involve bone mineral density, bone turnover, bone blood flow, DNA methylation, and/or physical function and fall risk. Genetic variation, especially polymorphisms of the gene encoding for methylenetetrahydrofolate reductase may play a role in homocysteine metabolism and fracture risk. It is uncertain whether supplementation with vitamin B12 and folate can decrease fracture incidence. One double blind clinical trial in post-stroke patients showed that these B vitamins could decrease hip fracture incidence, but the results of further clinical trials should be awaited before a definite conclusion can be drawn.

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Homocysteine and Mobility in Older Adults

Cited by 25 publications

References 33 publications

Cross-sectional and longitudinal association between homocysteine, vitamin B12 and physical performance in older persons

Cross-sectional and longitudinal association between homocysteine, vitamin B12 and physical performance in older persons

A Randomized Controlled Trial to Examine the Effect of 2-Year Vitamin B12 and Folic Acid Supplementation on Physical Performance, Strength, and Falling: Additional Findings from the B-PROOF Study

Vitamin B12, Folic Acid, and Bone

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