Homocysteine and Parkinson's disease

Zhou, Lingyan

doi:10.1111/cns.14420

Cited by 5 publications

(2 citation statements)

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“…Previous research 24,25 has demonstrated that the occurrence and development of PD are closely associated with multiple mechanisms, such as inflammation, oxidative stress, mitochondrial dysfunction, abnormal protein aggregation, and excessive N‐methyl‐D‐aspartate (NMDA) receptor activation. Homocysteine, uric acid, Cys C, and CRP are implicated in the pathogenesis and progression of degenerative diseases 26–28 . The elevated homocysteine and Cys C levels and lower low‐density lipoprotein cholesterol levels may enhance PD susceptibility 29,30 …”

Section: Discussionmentioning

confidence: 99%

“…The three models were compared after the discrimination, calibration, and decision curves in CRP are implicated in the pathogenesis and progression of degenerative diseases. [26][27][28] The elevated homocysteine and Cys C levels and lower low-density lipoprotein cholesterol levels may enhance PD susceptibility. 29,30 Initially, this study performed univariate analysis to screen for factors linked with PD symptom severity.…”

Section: Comparison Of Modelsmentioning

confidence: 99%

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The severity assessment of Parkinson's disease based on plasma inflammatory factors and third ventricle width by transcranial sonography

Lu,

Dong,

Xue

et al. 2024

CNS Neurosci Ther

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BackgroundPredicting Parkinson's disease (PD) can provide patients with targeted therapies. However, disease severity can be roughly evaluated in clinical practice based on the patient's symptoms and signs.ObjectiveThe current study attempted to explore the factors linked with PD severity and construct a predictive model.MethodThe PD patients and healthy controls were recruited from our study center while recording their basic demographic information. The serum inflammatory markers levels, such as Cystatin C (Cys C), C‐reactive protein (CRP), RANTES (regulated on activation, normal T cell expressed and secreted), Interleukin‐10 (IL‐10), and Interleukin‐6 (IL‐6) were determined for all the participants. PD patients were categorized into early and mid‐advanced groups based on the Hoehn and Yahr (H‐Y) scale and evaluated using PD‐related scales. LASSO logistic regression analysis (Model C) helped select variables based on clinical scale evaluations, serum inflammatory factor levels, and transcranial sonography measurements. The optimal harmonious model coefficient λ was determined via 10‐fold cross‐validation. Moreover, Model C was compared with multivariate (Model A) and stepwise (Model B) logistic regression. The area under the curve (AUC) of a receiver operator characteristic (ROC), brier score, calibration curve, and decision curve analysis (DCA) helped determine the discrimination and calibration of the predictive model, followed by configuring a forest plot and column chart.ResultsThe study included 113 healthy individuals and 102 PD patients, with 26 early and 76 mid‐advanced patients. Univariate analysis of variance screened out statistically significant differences among inflammatory markers Cys C and RANTES. The average Cys C level in the mid‐advanced stage was significantly higher than in the early stage (p < 0.001) but not for RANTES (p = 0.740). The LASSO logistic regression model (λ.1se = 0.061) associated with UPDRS‐I, UPDRS‐II, UPDRS‐III, HAMA, PDQ‐39, and Cys C as the included independent variables revealed that the Model C discrimination and calibration (AUC = 0.968, Brier = 0.049) were superior to Model A (AUC = 0.926, Brier = 0.079) and Model B (AUC = 0.929, Brier = 0.071) models.ConclusionThe study results show multiple factors are linked with PD assessment. Moreover, the inflammatory marker Cys C and transcranial sonography measurement could objectively predict PD symptom severity, helping doctors monitor PD evolution in patients while targeting interventions.

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Section: Discussionmentioning

confidence: 99%

Section: Comparison Of Modelsmentioning

confidence: 99%

The severity assessment of Parkinson's disease based on plasma inflammatory factors and third ventricle width by transcranial sonography

Lu,

Dong,

Xue

et al. 2024

CNS Neurosci Ther

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Amentoflavone attenuates homocysteine-induced neuronal ferroptosis-mediated inflammatory response: Involvement of the SLC7A11/GPX4 axis activation

Wang,

Jin

2024

Brain Research Bulletin

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Elevated circulating homocysteine concentrations delayed nerve conduction velocity and increase the risk of diabetic kidney disease in patients with type 2 diabetes

Lv,

Jia,

Liu

et al. 2024

Front. Endocrinol.

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IntroductionChina has the largest population of individuals with diabetes, and the prevalence of various complications among patients with type 2 diabetes remains high. Diabetic nephropathy affects approximately 20% to 40% of diabetic patients, becoming a major cause of chronic kidney disease and end-stage renal disease. Furthermore, around 50% of patients develop diabetic peripheral neuropathy (DPN), which is closely associated with physical disability, increased healthcare costs, and reduced work productivity. There is an urgent need for novel strategies in prevention, diagnosis, and treatment to improve patient outcomes.MethodsIn this study, 163 patients with type 2 diabetes were selected as the observation group and further divided into three subgroups based on homocysteine (HCY) levels. The study measured several clinical parameters, including homocysteine, blood glucose, blood lipids, glycated hemoglobin, urinary microalbumin, urinary albumin-to-creatinine ratio (ACR), electromyography, and highly-sensitive C-reactive protein (CRP), among others. The levels of these indicators were analyzed and compared across the subgroups.ResultsThe results revealed significant differences in uric acid, creatinine, urinary microalbumin, urinary ACR, and nerve conduction velocity (right tibial nerve sensory conduction) among different HCY levels in patients with type 2 diabetes (P < 0.05). Linear regression analysis indicated that homocysteine levels were associated with systolic blood pressure, glycated hemoglobin, fasting C-peptide, uric acid, creatinine, urinary microalbumin, and nerve conduction velocity (including motor conduction velocity of the ulnar nerve and sensory conduction velocity of the sural nerve).DiscussionThe clinical assessment of homocysteine in diabetic patients holds significant importance in the prevention of microvascular complications. Lowering HCY levels may offer a promising therapeutic approach for managing microvascular disease in diabetes.

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Homocysteine and Parkinson's disease

Cited by 5 publications

References 93 publications

The severity assessment of Parkinson's disease based on plasma inflammatory factors and third ventricle width by transcranial sonography

The severity assessment of Parkinson's disease based on plasma inflammatory factors and third ventricle width by transcranial sonography

Amentoflavone attenuates homocysteine-induced neuronal ferroptosis-mediated inflammatory response: Involvement of the SLC7A11/GPX4 axis activation

Elevated circulating homocysteine concentrations delayed nerve conduction velocity and increase the risk of diabetic kidney disease in patients with type 2 diabetes

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