While certain markers of inflammation and hemostasis are elevated in persons at risk for future cardiovascular events, data assessing the relation between inflammatory and hemostatic markers of vascular risk and race/ethnicity are limited. Thus, in a cross sectional analysis of the Women's Health Study (WHS), baseline soluble intercellular adhesion molecule-1 (ICAM-1), homocysteine and fibrinogen levels were measured among 23,687 women without a history of cardiovascular disease (CVD). Among 22,677 white, 242 Hispanic, 428 black and 340 Asian women, the distribution of median ICAM-1 levels was significantly lower among black (311.9 ng/ml, interquartile range (IQR) 220.1 -380.0) and Asian (312.7 ng/ml, IQR 267.3 -362.3) women than among white (343.1, IQR 301.9 -394.9) and Hispanic (351.9 ng/ml, IQR 305.9 -404.2) women (p value < 0.001). While homocysteine levels were marginally lower among Asian women (p=0.05), fibrinogen concentrations were higher among black women than their counterparts. After control for body mass index (BMI), hypertension, diabetes, smoking, alcohol use, family history of myocardial infarction, education, hormone use and lipids, ICAM-1 concentration remained significantly lower among black and Asian women. Meanwhile, homocysteine levels were lower in Asian women and fibrinogen levels remained higher in black women than their counterparts. In conclusion, this cross-sectional analysis revealed that baseline fibrinogen, ICAM-1 and homocysteine levels vary by self-reported race/ethnicity.