Homocysteine and Venous Thrombosis

Quéré, Isabelle; Gris, Jean-Christophe; Dauzat, M.

doi:10.1055/s-2005-872403

Cited by 23 publications

(7 citation statements)

References 41 publications

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“…However, the risk of cardiovascular comorbidities in psoriasis has been attributed also to many other independent risk factors including obesity, hypertension, smoking, dyslipidaemia, diabetes mellitus and increased levels of homocysteinaemia and mean platelet volume . Elevated plasma levels of homocysteinaemia is also considered a risk factor for venous thrombosis …”

Section: Introductionmentioning

confidence: 99%

Homocysteine plasma levels in psoriasis patients: our experience and review of the literature

Giannoni

Consales

Campanati

et al. 2015

Acad Dermatol Venereol

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Our results confirm that psoriasis patients with more severe disease, can have hyperhomocysteinaemia, without regard to disease duration or joint involvement. Hyperhomocysteinaemia is not influenced by a target therapy for psoriasis and it is as greater as psoriasis severity. However, limitation of our study is the relatively small number of cases. Homocysteine plasmatic levels should be advisable as a further independent risk factor for cardiovascular disease in psoriasis patients.

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Section: Introductionmentioning

confidence: 99%

Homocysteine plasma levels in psoriasis patients: our experience and review of the literature

Giannoni

Consales

Campanati

et al. 2015

Acad Dermatol Venereol

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“…The single nucleotide polymorphism of this gene reduces the ability of the MTHFR enzyme to catalyze the conversion of 5,10methylenetetrahydrofolate to 5-methyltetrahydrofolate and leads to the rise of plasma homocysteine levels in the homozygous mutated subjects, while the heterozygous mutated subjects have mildly raised Hcy levels compared to the normal, non-mutated controls [36][37][38][39]. All the patient members of the studied families presented the mutated polymorphism in a homozygous or heterozygous manner.…”

Section: Discussionmentioning

confidence: 99%

Hemostatic markers and polymorphisms in three Mexican families with Legg-Calvé-Perthes disease.

Rodríguez-Olivas

Hernández-Zamora

Casas-Ávila

et al. 2022

Preprint

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Background: Legg-Calvé-Perthes Disease (LCPD) is a condition caused by avascular necrosis of the femoral head. Although its etiology is still not fully understood, evidence suggests heritable thrombotic and inflammatory disorders and other factors may be implicated in its onset and progress. Our objective is to describe, in the three enrolled families, the genetic, biochemical, and environmental factors that may be associated with the etiology and development of LCPD. Methods: We evaluated the following gene alterations: MTHFR, CBS, PT, FVL, FVIII, FIX, PAI-1, eNOS, IL-23R, and TNF-α, and their relationship with LCPD. Additionally, we assessed thrombophilia-associated markers (FI, FII, FV, FVII, FVIII, FIX, FX, FXI, FXII, FvW, PC, PS, AT, and homocysteine) using coagulometry methods. Results: Seven patients with LCPD and 14 healthy volunteers were enrolled. Concentrations in hemoglobin (p ≤ 0.05), fibrinogen (p ≤ 0.05), homocysteine (p =<0.05), FVIII (p≤0.05), and factor IX activity percentage (p ≤ 0.05) showed statistically significant differences. Our results show that all participants of this study present at least one mutated allele for the MTFHR (rs1801133) and IL-23R (rs1569922) polymorphisms, as well as isolated cases with other genetic variants.Conclusions: Our results show environmental elements from every family and hemostatic and inflammatory disorders may be involved in suffering and developing LCPD. Also, heritable factors could contribute to the onset of the disease. Environmental, genetic, inflammatory, and prothrombotic factors are involved in this pathology.

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“…Homocysteine disturbances have emerged as risk factors for multiple pathological conditions, such as osteoporosis, venous thrombosis, osteonecrosis, and LCPD [38,39], while elevated Hcy levels have been associated with increased oxidative stress in the bone microenvironment. This could lead to increased osteoclast differentiation and activity.…”

Section: Discussionmentioning

confidence: 99%

“…It has been described that osteoblast activity is affected by Hcy concentration [38]. Hcy concentration, on the hand, can be altered by factors such as diet and lifestyle [39].…”

Section: Discussionmentioning

confidence: 99%

Familial cases of Mexican patients with Legg-Calvé-Perthes disease

Rodríguez-Olivas¹,

Zamora

Rosales-Cruz³

et al. 2021

Preprint

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BackgroundLegg-Calvé-Perthes Disease (LCPD) is described as an avascular necrosis of the femoral head. Although its etiology is still not fully understood, evidences suggest heritable thrombotic disorders and other factors may be implicated in its onset and progress. Our objective is to describe, in three enrolled families, the genetic, biochemical and environmental factors that may be associated with the etiology and development of LCPD. MethodsTherefore, we set out to evaluate the following alterations of collagen genes: MTHFR rs1801133, CBS rs115742905, and PT rs1799963 and their relationship with LCPD. Thrombophilia associated markers (FI, FII, FV, FVII, FVIII, FIX, FX, FXI, FXII, FvW, PC, PS, AT, and homocysteine) were evaluated using coagulometry methods. Results: Seven LCPD patients and 14 healthy volunteers were enrolled. Concentrations in hemoglobin (p ≤ 0.0001), fibrinogen (P ≤ 0.0001), homocysteine (p = 0.0414), factor IX activity percentage (p ≤ 0.0001), and protein S (p = 0.0478) showed statistically significant differences. None of the evaluated polymorphisms showed statistically significant differences. However, all patients presented the mutated MTHFR C677T polymorphism in a homozygous (T/T) or heterozygous manner (C/T).ConclusionsOur results show environmental elements from every family and hemostatic disorders may be involved in suffering and developing LCPD. Also, heritable factors could contribute to the onset of the disease. Clearly, environmental, genetic, and prothrombotic factors are involved in this pathology.

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Homocysteine and Venous Thrombosis

Cited by 23 publications

References 41 publications

Homocysteine plasma levels in psoriasis patients: our experience and review of the literature

Homocysteine plasma levels in psoriasis patients: our experience and review of the literature

Hemostatic markers and polymorphisms in three Mexican families with Legg-Calvé-Perthes disease.

Familial cases of Mexican patients with Legg-Calvé-Perthes disease

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