Homocysteine as a predictive biomarker in early diagnosis of renal failure susceptibility and prognostic diagnosis for end stages renal disease

Amin, Hatem K.; El-Sayed, Mohamed-I Kotb; Leheta, Ola

doi:10.1080/0886022x.2016.1209382

Cited by 17 publications

(17 citation statements)

References 51 publications

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“…However, increased serum or plasma HCY concentrations are less specific for intracellular lack of cobalamin than is increased serum MMA concentrations . Serum HCY concentrations can also be increased with renal insufficiency or hypothyroidism …”

Section: Laboratory Testing To Evaluate Cobalamin Statusmentioning

confidence: 99%

Review of cobalamin status and disorders of cobalamin metabolism in dogs

Kather¹,

Grützner

Kook

et al. 2019

Veterinary Internal Medicne

105

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Disorders of cobalamin (vitamin B 12 ) metabolism are increasingly recognized in small animal medicine and have a variety of causes ranging from chronic gastrointestinal disease to hereditary defects in cobalamin metabolism. Measurement of serum cobalamin concentration, often in combination with serum folate concentration, is routinely performed as a diagnostic test in clinical practice. While the detection of hypocobalaminemia has therapeutic implications, interpretation of cobalamin status in dogs can be challenging. The aim of this review is to define hypocobalaminemia and cobalamin deficiency, normocobalaminemia, and hypercobalaminemia in dogs, describe known cobalamin deficiency states, breed predispositions in dogs, discuss the different biomarkers of importance for evaluating cobalamin status in dogs, and discuss the management of dogs with hypocobalaminemia. K E Y W O R D S cobalamin deficiency, cubam receptor, folate, homocysteine, hypercobalaminemia, hypocobalaminemia, methylmalonic acid, vitamin B 12

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Section: Laboratory Testing To Evaluate Cobalamin Statusmentioning

confidence: 99%

Review of cobalamin status and disorders of cobalamin metabolism in dogs

Kather¹,

Grützner

Kook

et al. 2019

Veterinary Internal Medicne

105

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“…Kidney is organ that has central role in metabolism of homocysteine, because it contains all metabolizing enzymes: MS, CBS and CTH. Rise in values of tHcy is observed in early stages of renal failure, and during progression of the disease the values of tHcy increase (Ferechide and Radulescu 2009;Amin et al 2016;Tak et al 2016). The hyperhomocysteinemia in patients with terminal phases of renal failure (dialysed patients) could be the consequence of several causes: the decreased renal excretion of homocysteine due to impaired renal function, disturbance in homocysteine metabolism, alimentary deficiency in vitamins included in homocysteine metabolism, and undiagnosed genetic abnormalities of metabolizing enzymes (Sette and…”

Section: Basic Mechanisms In Development Of Hyperhomocysteinemiamentioning

confidence: 99%

Homocysteine and homocysteine-related compounds: an overview of the roles in the pathology of the cardiovascular and nervous systems

Djuric

Jakovljević

Živković

et al. 2018

Can. J. Physiol. Pharmacol.

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Homocysteine, an amino acid containing a sulfhydryl group, is an intermediate product during metabolism of the amino acids methionine and cysteine. Hyperhomocysteinemia is used as a predictive risk factor for cardiovascular disorders, the stroke progression, screening for inborn errors of methionine metabolism, and as a supplementary test for vitamin B deficiency. Two organic systems in which homocysteine has the most harmful effects are the cardiovascular and nervous system. The adverse effects of homocysteine are achieved by the action of several different mechanisms, such as overactivation of N-methyl-d-aspartate receptors, activation of Toll-like receptor 4, disturbance in Ca handling, increased activity of nicotinamide adenine dinucleotide phosphate-oxidase and subsequent increase of production of reactive oxygen species, increased activity of nitric oxide synthase and nitric oxide synthase uncoupling and consequent impairment in nitric oxide and reactive oxygen species synthesis. Increased production of reactive species during hyperhomocysteinemia is related with increased expression of several proinflammatory cytokines, including IL-1β, IL-6, TNF-α, MCP-1, and intracellular adhesion molecule-1. All these mechanisms contribute to the emergence of diseases like atherosclerosis and related complications such as myocardial infarction, stroke, aortic aneurysm, as well as Alzheimer disease and epilepsy. This review provides evidence that supports the causal role for hyperhomocysteinemia in the development of cardiovascular disease and nervous system disorders.

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“…While the literature extensively addresses hs-CRP for the prediction of outcomes of late-stage CKD patients, there is still limited research on the associations between hs-CRP and mild or early RI. A few studies have reported an inverse association between the hs-CRP level and GFR [29,30]. A recent study has also reported a link between hs-CRP elevation and urinary alpha-1 microglobulin (A1MG), an early sign of renal damage, in type II diabetes patients [31].…”

Section: Possibility Of Using Hs-crp In Risk Stratification For Rimentioning

confidence: 99%

High-Sensitivity C-Reactive Protein Elevation Is Independently Associated with Subclinical Renal Impairment in the Middle-Aged and Elderly Population—A Community-Based Study in Northern Taiwan

Chuang

Lin

et al. 2020

IJERPH

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This cross-sectional study aimed to investigate the associations between high-sensitivity C-reactive protein (hs-CRP) and renal impairment (RI) among middle-aged and elderly people. We collected and analyzed demographic, anthropometric, metabolic, and renal function data in a community-based population in Northern Taiwan. We excluded subjects with acute inflammation from this study and defined RI as the presence of urinary albumin–creatinine ratio 30–300 mg/g or an estimated glomerular filtration rate of <60 mL/min/1.73 m2. There were 131, 125, and 125 participants in the low (≤0.80 mg/L), middle (0.81–1.76 mg/L), and high (>1.77 mg/L) hs-CRP tertiles, respectively. hs-CRP exhibited significantly positive correlations with body mass index, waist circumference, systolic blood pressure, triglyceride, and fasting plasma glucose, and a negative correlation with high-density lipoprotein. The prevalence and odds ratio of RI significantly increased across hs-CRP tertiles from low to high, and this trend remained significant after adjusting for the conventional cardiometabolic risk factors. hs-CRP ≥ 1.61 mg/L in the total group and ≥2.03 mg/L in the elderly group accurately predicted RI (p = 0.01 and 0.03, respectively). These findings suggest that we should carefully evaluate the renal function for at-risk individuals with hs-CRP elevation.

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Homocysteine as a predictive biomarker in early diagnosis of renal failure susceptibility and prognostic diagnosis for end stages renal disease

Cited by 17 publications

References 51 publications

Review of cobalamin status and disorders of cobalamin metabolism in dogs

Review of cobalamin status and disorders of cobalamin metabolism in dogs

Homocysteine and homocysteine-related compounds: an overview of the roles in the pathology of the cardiovascular and nervous systems

High-Sensitivity C-Reactive Protein Elevation Is Independently Associated with Subclinical Renal Impairment in the Middle-Aged and Elderly Population—A Community-Based Study in Northern Taiwan

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