Homocystéine et paramètres du syndrome métabolique et du risque cardiovasculaire chez 2045 militaires : étude EPIMIL

Chellak, Saliha; Bigaillon, C.; Jahiri, Y. El; Garcia, C.; Ceppa, F.; Mayaudon, H.; Dupuy, O.; Garcin, J. M.; Baigts, F.; Bauduceau, B.; Burnat, P.

doi:10.1016/j.immbio.2005.03.002

Cited by 6 publications

(4 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…High levels of Hcy were associated with hypercholesterolemia and hypertriglyceridaemia within our study population. The results which are in line with those found in the study of Chellak et al [53] in 2045 military subjects, were showed synergistic linkage of Hcy with CT and TG in the maintenance of Journal of Biosciences and Medicines atherosclerosis. Indeed abnormal concentrations of Hcy promote atherogenesis in three ways [54]: by a direct toxic effect on the cells of the internal wall of the arteries, by proliferation of the smooth muscle cells and by the oxidation of the LDL-c.…”

Section: • Lipid Profilesupporting

confidence: 91%

Evaluation of Cardiovascular Risk Factors in a Young Adults Tunisian Group

Lamine¹,

Sana²,

Grira³

et al. 2018

JBM

View full text Add to dashboard Cite

Introduction: Cardiovascular diseases have become more common in young adults. Their emergence is due to the prevalence of cardiovascular risk factors. The aim of this study is to determine the prevalence of cardiovascular risk factors in a Tunisian young adult group. Material and methods: This is an epidemiological study of 705 Tunisians volunteers, free from any cardiovascular pathology; who are recruited at the Military Hospital of Tunis. Besides the classical cardiovascular risk factors (obesity, dyslipidemia, smoking, alco-hol…), we evaluate the level of homocysteinemia and determined the C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene by PCR-RFLP method. Results and conclusions: The mean age of our population is 28.25 ± 9.08 with a male majority (83.8%). We have 43.8% obese subject or overweight, 54.3% smokers and 12.9% alcoholics. The lipid profile showed that 12.6% of the population had hypercholesterolemia and 39.5% had hypoHDLemia, 7.9% had a high lipoprotein(a) concentration. In our study population we found that 10.9% of subjects had an hs-CRP concentration greater than 3 mg/L. Genotyping of the MTHFR gene revealed that 34% of young adults had a mutated genome (CT). The results showed a significant correlation between different factors, such as cholesterolemia and obesity. The prevalence of these risk factors showed the severity of our young people's health status and imposes a change in the way of Tunisians life.

show abstract

Section: • Lipid Profilesupporting

confidence: 91%

Evaluation of Cardiovascular Risk Factors in a Young Adults Tunisian Group

Lamine¹,

Sana²,

Grira³

et al. 2018

JBM

View full text Add to dashboard Cite

show abstract

“…Chez des patients atteints d'une maladie coronarienne, on a rapporté que 48 % avaient une HHcy [24]. Dans l'étude EPIMIL chez des militaires masculins, une HHcy modérée (> 12 mmol/L) était observée chez 29 % des sujets [25]. En Afrique de l'Ouest, une HHcy (> 15 mmol/L) a été observée chez 62,3 % des sujets de la zone côtière du Togo et du Bénin, alors qu'un taux beaucoup plus faible (29,4 %) était enregistré en zone de savane du Togo [10] ; cette étude portait toutefois sur un petit effectif de 276 sujets au total, dont 127 de la zone côtière du Togo, 81 du Bénin et 68 de la zone de la savane du Togo.…”

Section: Discussionunclassified

“…Nous pourrions dire que l'HHcy serait un marqueur d'un style de vie qui pourrait prédire le risque cardiométabolique. Nos résultats rejoignent ceux de l'étude EPIMIL chez les militaires français en ce que l'Hcy était aussi reliée à la pression artérielle et au cholestérol total, mais non aux autres composantes du syndrome métabolique [25]. L'HHcy étant associée dans notre étude avec des apports faibles en vitamine B12 et avec la consommation de bière (chez les hommes), il serait opportun de promouvoir, dans la mesure où les moyens le permettent, une consommation accrue de denrées d'origine animale sources de vitamine B12, comme d'encourager une consommation modérée d'alcool.…”

Section: Article Originalunclassified

Homocystéinémie : déterminants et relation avec les facteurs de risque cardiométabolique au Bénin (Afrique de l’Ouest)

2010

View full text Add to dashboard Cite

“…The effective response to this public health challenge requires prior identification of the level of exposure of populations in order to implement actions to reduce the risk factors. Several nations have therefore assessed the extent of NCDs in their military populations [3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Surveillance of Cardiovascular Risk Factors in the Fifth Military Sector Health Center, Ngaoundéré, Cameroon: Observational Study

Ngan

Belinga

Nlo'o³

et al. 2020

JMIR Form Res

View full text Add to dashboard Cite

Background Noncommunicable diseases (NCDs) are the leading causes of death worldwide. They were responsible for 40 million of the 57 million deaths recorded worldwide in 2016. In Cameroon, epidemiological studies have been devoted to NCDs and their risk factors. However, none provides specific information on their extent or the distribution of their risk factors within the Cameroonian defense forces. Objective The objective of our study was to assess the cardiovascular risk of a Cameroonian military population compared with that of its neighboring civilian population. Methods We conducted a cross-sectional study that involved subjects aged 18 to 58 years, recruited from October 2017 to November 2018 at the Fifth Military Sector Health Center in Ngaoundéré, Cameroon. Data collection and assessment were done according to the World Health Organization (WHO)’s STEPS manual for surveillance of risk factors for chronic NCDs and the Alcohol Use Disorders Identification Test. Five cardiovascular risk factors were assessed: smoking, harmful alcohol consumption, obesity/overweight, hypertension, and diabetes. The risk was considered high in subjects with 3 or more of the factors. Univariate analysis and multivariate logistic regression were carried out according to their indications. Results Our study sample of 566 participants included 295 soldiers and 271 civilians of the same age group (median age 32 years versus 33 years, respectively; P=.57). The military sample consisted of 31 officers and 264 noncommissioned officers (NCOs). Soldiers were more exposed to behavioral risk factors than civilians, with a prevalence of smoking of 13.9% versus 4.4% (P<.001) and excessive alcohol consumption of 61.7% versus 14.8% (P<.001). They also presented with a higher cardiovascular risk than civilians (odds ratio 2.7, 95% CI 1.50-4.81; P<.001), and among the military participants, the cardiovascular risk was higher for officers than for NCOs (51.6% versus 14.0%, respectively; P<.001). Conclusions Cameroonian soldiers are particularly exposed to cardiovascular behavioral risk factors and consequently are at higher risk of NCDs. Trial Registration ClinicalTrials.gov NCT04315441; https://clinicaltrials.gov/ct2/show/NCT04315441

show abstract

Homocystéine et paramètres du syndrome métabolique et du risque cardiovasculaire chez 2045 militaires : étude EPIMIL

Cited by 6 publications

References 9 publications

Evaluation of Cardiovascular Risk Factors in a Young Adults Tunisian Group

Evaluation of Cardiovascular Risk Factors in a Young Adults Tunisian Group

Homocystéinémie : déterminants et relation avec les facteurs de risque cardiométabolique au Bénin (Afrique de l’Ouest)

Surveillance of Cardiovascular Risk Factors in the Fifth Military Sector Health Center, Ngaoundéré, Cameroon: Observational Study

Contact Info

Product

Resources

About