Homocysteine, folate and vitamin B12 in puerperal cerebral venous thrombosis

Nagaraja, D; Noone, Mohan Leslie; Bharatkumar, Venkata Pinnelli; Christopher, Rita

doi:10.1016/j.jns.2008.03.021

Cited by 31 publications

(25 citation statements)

References 18 publications

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“…hyperhomocysteinemia in patients with CVT. 13,16,17,29,30 Researchers from Milan 13 reported on 121 patients with a first CVT and 242 control subjects, finding hyperhomocysteinemia in 33 patients (27%) and 20 control subjects (8%; OR 4.2, 95% CI 2.3 to 7.6). Low levels of serum folate and the 677TT methylenetetrahydrofolate reductase genotype were not associated with CVT risk, independent of homocysteine level.…”

Section: Hyperhomocysteinemiamentioning

confidence: 99%

See 1 more Smart Citation

Diagnosis and Management of Cerebral Venous Thrombosis

Saposnik¹,

Barinagarrementería²,

Brown³

et al. 2011

Stroke

1,697

1,229

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Background— The purpose of this statement is to provide an overview of cerebral venous sinus thrombosis and to provide recommendations for its diagnosis, management, and treatment. The intended audience is physicians and other healthcare providers who are responsible for the diagnosis and management of patients with cerebral venous sinus thrombosis. Methods and Results— Members of the panel were appointed by the American Heart Association Stroke Council's Scientific Statement Oversight Committee and represent different areas of expertise. The panel reviewed the relevant literature with an emphasis on reports published since 1966 and used the American Heart Association levels-of-evidence grading algorithm to rate the evidence and to make recommendations. After approval of the statement by the panel, it underwent peer review and approval by the American Heart Association Science Advisory and Coordinating Committee. Conclusions— Evidence-based recommendations are provided for the diagnosis, management, and prevention of recurrence of cerebral venous thrombosis. Recommendations on the evaluation and management of cerebral venous thrombosis during pregnancy and in the pediatric population are provided. Considerations for the management of clinical complications (seizures, hydrocephalus, intracranial hypertension, and neurological deterioration) are also summarized. An algorithm for diagnosis and management of patients with cerebral venous sinus thrombosis is described.

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Section: Hyperhomocysteinemiamentioning

confidence: 99%

“…35 Recently, it was reported that in pregnant women, hyperhomocysteinemia was associated with increased risk of puerperal CVT (OR 10.8, 95% CI 4.0 to 29.4) in a study of 60 case subjects and 64 control subjects. 30 …”

Section: Pregnancy and Puerperiummentioning

confidence: 99%

Diagnosis and Management of Cerebral Venous Thrombosis

Saposnik¹,

Barinagarrementería²,

Brown³

et al. 2011

Stroke

1,697

1,229

View full text Add to dashboard Cite

show abstract

“…Its incidence is about 0.5% to 1.0% among all types of stroke [1][2][3]. There are many risk factors of CVT [1][2][3]; genetic or acquired thrombophrenia and oral contraceptive use are the most common risk factors, and hyper-homocysteinemia (Hcy) is an additional risk factor [4][5][6][7][8]. A meta-analysis of 17 clinical studies showed that oral contraceptive use, Leiden mutation of Factor V, and hyperHcy were recognized as statistically significant risk factors 8).…”

Section: Archivos De Medicina Issn 1698-9465 Journal Of Neurology Andmentioning

confidence: 99%

Cerebral Venous Sinus Thrombosis: Incidence and Hyperhomocysteinemia as a Risk Factor in Japanese Patients

Takemaru¹,

Kuriyama²,

Himeno³

et al. 2017

J Neurol Neurosci

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“…5 This is further compounded by genetic mutations. Although clinical and biochemical series have been reported 6 , reports that describe the associated pathology in the brain are limited. A 38-year-old man with chronic alcohol dependency was admitted to the neurological services of the National Institute of Mental Health and Neurosciences, Bangalore, India with a history of diffuse holocranial headache of 3 days duration and generalized tonic-clonic status epilepticus of 2 days duration.…”

Section: Dear Professor Kayementioning

confidence: 99%

“…2,3,6 Homocysteine is derived from dietary methionine by demethylation. The remethylation pathway requires the enzyme, methylenetetrahydrofolate reductase (MTHFR), to convert 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate.…”

Section: Dear Professor Kayementioning

confidence: 99%