Homocysteine, folic acid and B12 serum levels in pregnancy complicated with preeclampsia

Makedos, G; Papanicolaou, A. N.; Hitoglou, Areti; Kalogiannidis, Ioannis; Makedos, Anastasios; Vrazioti, Violeta; Goutzioulis, Michalis

doi:10.1007/s00404-006-0223-2

Cited by 78 publications

(64 citation statements)

References 18 publications

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“…7 Several other studies were in consonance with the present study. 5,6,[8][9][10] On the contrary Zeeman GG et al did not agree with our observations and there was no significant difference in maternal serum levels of homocysteine between pre-eclampsia and normal pregnancy (5.1±1.7 μmol/l vs 4.7±1.3 μmol/l p value =0.56) and they stated that serum homocysteine levels were not helpful in the prediction of PE. 11 Hietala R et al also stated that there was no difference between pre-eclampsia and normotensive women (6.42, 7.55μmol/l vs 6.45, 7.34 μmol/l).…”

Section: Discussioncontrasting

confidence: 96%

“…Premlata et al showed the mean levels of severe PE and mild PE 15.9±6.3 vs 12.3±4.2 (p value =0.01). 4 Several other studies were in consonance with the her results such as Khosrowbeygi A et al and Makedos G et al 6,10 Based on the findings of present study it can be concluded that maternal serum homocysteine seems to have a causal role in pathogenesis of pre-eclampsia, however measurement of homocysteine concentration did not determine the severity of pre-eclampsia. In present study the pre-eclamptic group had higher incidence of caesarean sections (56.66%).…”

Section: Discussionsupporting

confidence: 89%

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Hyperhomocysteinemia in pre-eclampsia: is routine screening rational?

Miglani

Nautiyal

Prakash

2017

Int J Reprod Contracept Obstet Gynecol

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Background: Hypertensive disorders complicate upto 5 to 10% of all pregnancies. Though the exact cause of pre-eclampsia is still undecided, maternal hyperhomocysteinemia has been implicated as a risk factor for pre eclampsia, placental abruption and other vascular diseases. The objectives of present study were to estimate the levels of serum homocysteine in antenatal patients and to study the above parameters in patients of pre-eclampsia.Methods: A prospective observational study was performed with 30 pre eclamptic patients and an equal number taken as control having comparable demographic characteristics. Level of homocysteine was measured by an enzymatic method, using Diazyme homocysteine 2 reagent enzymatic assay kit on Beckman coulter analyzer in all the patients. Obstetrics and neonatal outcomes were observed in all the patients. The statistical analysis was done using unpaired T test for determining level of significance.Results: Mean Serum homocysteine in the study group was 13.99±5.46 µmol/l and was 6.03±2.58 µmol/l in control group. This was statistically significant (p value 0.002). However the mean values of serum homocysteine did not correlate with severity of pre-eclampsia 14.32±6.72 µmol/l in mild pre-eclampsia and 13.60±3.77μmol/l in severe pre-eclampsia respectively (p value - 0.727).Conclusions: It appears that maternal serum homocysteine has a causal role in pathogenesis of pre eclampsia, however to recommend it as a routine test, larger studies are required.

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Section: Discussioncontrasting

confidence: 96%

Section: Discussionsupporting

confidence: 89%

Hyperhomocysteinemia in pre-eclampsia: is routine screening rational?

Miglani

Nautiyal

Prakash

2017

Int J Reprod Contracept Obstet Gynecol

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“…There was no between-group difference in the folic acid and vitamin B12 levels. The group of women with preeclampsia was associated with a higher rate of cesarean section, IUGR (50%) and abruptio placentae (20).…”

Section: Discussionmentioning

confidence: 98%

“…Our results showed the mean homocysteine level (6.758±2.062 μmol/L) and median (6.400 μmol/L) calculated for women with preeclampsia to exceed the respective values recorded in the control group of women free from preeclampsia (6.014±1.539 μmol/L and 5.800 μmol/L); however, the between-group difference in homocysteine levels did not reach statistical significance. Makedos et al (20) compared homocysteine levels in a group of pregnant women with preeclampsia and control group free from preeclampsia and found the mean homocysteine level to be significantly increased in the former (11.11 μmol/L vs. 6.40 μmol/L, p<0.001). There was no between-group difference in the folic acid and vitamin B12 levels.…”

Section: Discussionmentioning

confidence: 99%

Maternal and umbilical homocysteine in preeclampsia

Bobić

Habek

2016

Period Biol

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Background and purpose: Were to assess the association between homocysteine levels and development of preeclampsia, to determine homocysteine levels in fetal circulation, to differentiate homocysteine levels in mild and severe preeclampsia and to compare homocysteine levels in pregnant women with preeclampsia with homocysteine levels measured in the same group of women six months after delivery. Material and methods: IntroductIon Since the 1990s, homocysteine has been associated with disorders of the fetomaternal unit (1). Studies on recurrent abortions also found clear association between elevated homocysteine levels and the risk of abortion (2,3). Later on, Vollset et al. (4) found the levels of homocysteine to be associated with the prevalence of preeclampsia, preterm delivery, low birth weight, intrauterine growth restriction (IUGR), stillbirth, congenital malformations and abruptio placentae. The association of mild hyperhomocysteinemia with cardiovascular disease and related mortality was demonstrated in a number of studies (5-11).Hyperhomocysteinemia alters vascular morphology, stimulates inflammation, activates endothelium and blood clotting cascade, and inhibits fibrinolysis. Hyperhomocysteinemia results in the loss of endothelial antithrombin function and induction of a procoagulant setting (9,12). The pathogenetic action of homocysteine also includes interference with the nitric oxide (NO) system (homocysteine reduces NO bioavailability by interfering with its synthesis), activation of transcrip- (13,14). The aims of the study were to assess the association between elevated homocysteine levels and development of preeclampsia; to determine homocysteine levels in fetal circulation; to differentiate homocysteine levels in mild and severe preeclampsia; and to compare homocysteine levels in pregnant women with preeclampsia with homocysteine levels measured in the same group of women six months after delivery. methodsThe study included 55 pregnant women with verified milde preeclampsia (blood pressure measured on two occasions at least 4 h apart ≥140/90 mm Hg after 20 th week of gestation, and positive proteinuria) and severe preeclampsia (blood pressure ≥160/110 mm Hg, proteinuria ≥++). Control group consisted of 50 healthy pregnant women, as approved by the Ethics Committee of the Osijek University Hospital. All pregnant women are taking folate supplements and vitamins, including B6 and B12 during pregnancy and puerperium (Elevit®, Bayer, Germany). In both preeclampsia and control group, homocysteine levels were measured after at least 12-h fasting. Umbilical blood homocysteine levels were determined in the same groups of women after delivery, during third stage. In the group of women with preeclampsia, blood homocysteine was also determined six months after delivery. Homocysteine levels were determined by the FPIA (fluorescence polarization immunoassay) technology on an AxSYM device (Abbott Laboratories) using reagents of the same manufacturer . According to Khong and Hague (15), hyperhomocyst...

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“…Alzheimer's disease), hypothyroidism, birth defects and late pregnancy complications, such as preeclampsia, intrauterine grow retardation, preterm birth and intrauterine fetal death and abruption of placenta [1][2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Intraindividual variability of homocysteine and related thiols concentrations in follicular fluid

Králíková

Melounová

Crha

et al. 2011

J Assist Reprod Genet

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Purpose To determine intraindividual variability in concentrations of homocysteine and related thiols in follicular fluids of particular follicles after ovarian stimulation and assess the differences between follicles with/or without oocytes. Methods HPLC-FD analysis of plasma and follicular fluid cysteine, homocysteine, cysteinylglycine and glutathione in women undergoing IVF.Results In blood plasma, the homocysteine, cysteine, and cysteinylglycine concentrations decreased significantly during stimulation with rec FSH (p<0.001). We found significant differences in concentrations of cysteine and glutathione between follicles with or without retrieved oocytes. High intraindividual variability in concentrations of thiols was determined. Conclusions The concentration variability of thiols between single follicles is very high and we recommend mean at least from 3 follicles with/or without oocytes for characterization of each woman. It is the best to examine individual follicles for further research and analysis of fertility outcomes.

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Homocysteine, folic acid and B12 serum levels in pregnancy complicated with preeclampsia

Abstract: It is concluded that in our study homocysteine levels are significantly elevated in patients with preeclampsia compared with control group, while no vitamin deficiencies were observed.

Cited by 78 publications

References 18 publications

Hyperhomocysteinemia in pre-eclampsia: is routine screening rational?

Hyperhomocysteinemia in pre-eclampsia: is routine screening rational?

Maternal and umbilical homocysteine in preeclampsia

Intraindividual variability of homocysteine and related thiols concentrations in follicular fluid

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