Homocysteine-Induced Endothelial Dysfunction

Lai, Christopher; Kan, Ming Yin

doi:10.1159/000437098

Cited by 286 publications

(233 citation statements)

References 67 publications

(111 reference statements)

Supporting

Mentioning

220

Contrasting

Unclassified

Order By: Relevance

“…47 Elevated Hcy is associated with endothelial cell dysfunction in atherosclerosis and small vessel disease. 48,49 Baroreflex regulation of arterial pressure is negatively correlated with plasma Hcy concentration in XFS/XFG. 50 Abnormal endothelial cell function due to elevated Hcy may influence regulation of vascular tone in XFS/XFG rendering the nailfold capillaries tortuous and prone to leakage.…”

Section: Discussionmentioning

confidence: 99%

Nailfold capillary morphology in exfoliation syndrome

Cousins

Kang

Bovee

et al. 2017

Eye

View full text Add to dashboard Cite

Purpose The purpose of the study was to investigate nailfold microvascular morphology in exfoliation syndrome with or without glaucoma (XFS/XFG) compared with primary open-angle glaucoma (POAG) and control subjects using nailfold capillary videomicroscopy. Patients and methods We used a JH-1004 capillaroscope to perform nailfold capillary videomicroscopy on the fourth and fifth digit of the non-dominant hand. We enrolled 56 XFS/XFG patients, 87 POAG patients, and 75 control subjects. Masked observers graded the videos for hemorrhages, avascular zones ≥ 200 microns (μm), and degree of microvascular tortuosity on a four-point subjective scale. Multivariable odds ratios, 95% confidence intervals and P-for trends for assessing the relation between morphological changes and POAG or XFS/XFG were obtained from logistic regression analyses. We also assessed this relation with XFS/XFG compared with POAG in multivariable models. Results After adjusting for multiple covariates, nailfold hemorrhages, avascular zones ≥ 200 μm, and higher degree of vascular tortuosity were more common in XFS/XFG vs controls (P-for trend ≤ 0.0001) and in POAG vs controls (P-for trend ≤ 0.01). For each 100 capillaries, the number of hemorrhages was similar (P-for trend = 0.91) between XFS/XFG and POAG patients; however, there were more avascular zones per 100 capillaries with borderline significance (P-for trend = 0.04) in the XFS/XFG group. XFS/XFG patients had more tortuosity than POAG patients; specifically, having a tortuosity score ≥ 1.5 was associated with a 4.4-fold increased odds of XFS/XFG (95% confidence interval: 1.5-13.3) relative to a tortuosity score o1.0 (P-for trend = 0.005). Conclusion A high degree of nailfold capillary tortuosity is a distinct non-ocular feature associated with XFS/XFG compared with either POAG or controls.

show abstract

Section: Discussionmentioning

confidence: 99%

Nailfold capillary morphology in exfoliation syndrome

Cousins

Kang

Bovee

et al. 2017

Eye

View full text Add to dashboard Cite

show abstract

“…Together, these contribute to increased systemic vascular resistance, thus leading to the development of hypertension. 31,32 Hypertension can further trigger and potentiate endothelial dysfunction, which can lead to irreversible damage to the heart and , male=1), course, diabetes mellitus (no = 0, yes = 1), current smoker (no = 0, yes = 1), alcohol intake (no = 0, yes = 1), body mass index (BMI), hemoglobin, albumin, calcium9phosphate, intact parathyroid hormone (iPTH), uric acid, cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), urinary sodium excretion, proteinuria and normotension and hyperhomocysteinemia (NH), hypertension and normohomocysteinemia (HN), and H-type hypertension (HH) (no = 0, yes = 1) (vs normotension and normohomocysteinemia [NN]). Variables of simple regression analysis for left ventricular mass index (LVMI) and carotid intima-media thickness (cIMT) include sex (female=0, male=1), course, diabetes mellitus (no = 0, yes = 1), current smoker (no=0, yes=1), alcohol intake (no = 0, yes = 1), BMI, hemoglobin, albumin, calcium9phosphate, iPTH, uric acid, cholesterol, triglyceride, HDL-C, LDL-C, urinary sodium excretion, proteinuria, eGFR, NH, HN, and HH (no = 0, yes = 1) (vs NN).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Homocysteine‐Related Hypertension in Patients With Chronic Kidney Disease

Wang

Zhang

et al. 2016

J of Clinical Hypertension

View full text Add to dashboard Cite

Patients with both hypertension and hyperhomocysteinemia, termed H‐type hypertension, have a high risk for cardiocerebrovascular diseases. However, little is known about the prevalence of H‐type hypertension or its role in target organ damage in patients with chronic kidney disease (CKD). The authors recruited 1042 patients with CKD who were admitted to their hospital division. Multiple linear regression analyses were used to evaluate the association between H‐type hypertension and renal/cardiovascular parameters. A total of 460 (44.14%) CKD patients had H‐type hypertension. Multivariate logistic regression analysis showed that H‐type hypertension is associated with serum albumin, uric acid, estimated glomerular filtration rate (eGFR), and 24‐hour systolic blood pressure. Patients with H‐type hypertension had the worst renal function and left ventricular hypertrophy among all patients, while the levels of carotid intima‐media thickness (cIMT) in patients with H‐type hypertension were only slightly higher than in patients with normotension and normohomocysteinemia (P<.05). H‐type hypertension was associated with eGFR, left ventricular mass index, and cIMT according to multiple linear regression analyses. The prevalence of H‐type hypertension was high and H‐type hypertension was associated with target organ damage in patients with CKD.

show abstract

“…Elevated Hcy levels confer increase in mortality from coronary heart disease (CHD), cardiovascular disease (CVD) and all-cause mortality [5][6][7][8]. A meta-analysis of twelve studies comprising 23623 subjects calculated the core elements of Hcy risk estimate: the pooled adjusted risk ratio (RR) and the corresponding 95% confidence levels [5].…”

Section: Introductionmentioning

confidence: 99%

“…Despite the lack of universal agreement regarding the cut-off level to classify the condition as h-Hcy, hHcy is accepted as the independent cardiovascular risk factor. The complex roles of hyper-homocysteine in cardiovascular functions may be summarized in the context of impaired endothelial function [7]. Nitric oxide orchestrates the oxidative stress load and the coupling of nitric oxide synthetase activity.…”

Section: Introductionmentioning

confidence: 99%

Exploratory study of sublimed sulfur, in cognitively normal subjects and in Alzheimer’s dementia (AD) subjects: implications for Sulfur targeting Hydrogen sulfide (H2S)/Homocysteine (Hcy) and beta-galactosidase (GALAC)/Autophagy Signaling in AD

Chiu¹,

Khan²,

Badmaev³

et al. 2017

J Syst Integr Neurosci

View full text Add to dashboard Cite

Introduction: There is mounting evidence to suggest that hyper-homocysteinemia (eHct) correlates with cognitive decline severity and cortical atrophy in AD. Hydrogen Sulfide (H 2 S) exerts neuroprotection through regulating Homocysteine (eHcy) signaling. Elemental sulfur can mediate H 2 S neuroprotection through the trans-sulfuration pathway and correct the the dysregulation of H 2 S /Hct signaling in AD. Sublimed Sulfur, formulated as SULMEDOL and approved for the treatment of lactose intolerance, activates gut beta-galactosidase (GALAC). We repurpose Sulmedol from lactose intolerance to likely CNS effect, since gut GALAC cross-talks with senescence-related GALAC expression in the brain. In view of the known regulatory function of GALAC in CNS endosomal-lysosomal autophagy system , we propose that SULMEDOL may rescue aberrant autophagy in AD.

show abstract

Homocysteine-Induced Endothelial Dysfunction

Cited by 286 publications

References 67 publications

Nailfold capillary morphology in exfoliation syndrome

Nailfold capillary morphology in exfoliation syndrome

Prevalence of Homocysteine‐Related Hypertension in Patients With Chronic Kidney Disease

Exploratory study of sublimed sulfur, in cognitively normal subjects and in Alzheimer’s dementia (AD) subjects: implications for Sulfur targeting Hydrogen sulfide (H2S)/Homocysteine (Hcy) and beta-galactosidase (GALAC)/Autophagy Signaling in AD

Contact Info

Product

Resources

About