Homocysteine Induces Inflammation in Retina and Brain

Yun

et al. 2020

Preprint

Introduction: This study aimed to investigate the relationship between H-type hypertension and retinal vessel abnormalities. Methods: Hypertensive patients were retrospectively enrolled in this study. According to serum homocysteine (HCY), patients were divided into isolated hypertension and H-type hypertension group. Retinal fundus photography was used to evaluate the diameter of retinal vessels and retinopathy. Univariate and multivariate regression were used to investigate difference of retinal vessel abnormalities between H-type hypertension and isolated hypertension patients. Results: A total of 191 hypertensive patients were included, of which 85 were isolated hypertension and 106 were H-type hypertension. H-type hypertension patients had a higher ratio of retinopathy(P=0.004) and higher degree of retinal arteriosclerosis (P=0.005). CRAE(P=0.002) and AVR(P=0.001) were smaller in H-type hypertension group. Multivariate analysis showed that after adjusting for age, sex, course of hypertension and diabetes, H-type hypertension were still risk factor of retinopathy(OR, 2.259; 95%CI, 1.165—4.378; P=0.016), CRAE (B=-5.669; 95%CI, -9.452—-1.886; P=0.004), and AVR(B=-0.023; 95%CI,-0.039—-0.007; P=0.005). Conclusion: H-type hypertension may aggravate retinal vessel abnormalities compared with isolated hypertension.

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

The Association Between Retinal Vessel Abnormalities and H-type Hypertension

Yun

et al. 2020

Preprint

“…Another potential biomarker related with DNA methylation in DR is homocysteine, of which high levels have been associated with increased risk of developing DR in diabetic patients, and with higher global DNA methylation probably linking it to altered metabolic memory phenomenon [248,249]. Interestingly, high homocysteine levels have been associated with increased inflammatory cytokines and activation of NF-kB [250].…”

Section: Dna Methylationmentioning

confidence: 99%

Importance of the Use of Oxidative Stress Biomarkers and Inflammatory Profile in Aqueous and Vitreous Humor in Diabetic Retinopathy

et al. 2020

Diabetic retinopathy is one of the leading causes of visual impairment and morbidity worldwide, being the number one cause of blindness in people between 27 and 75 years old. It is estimated that ~191 million people will be diagnosed with this microvascular complication by 2030. Its pathogenesis is due to alterations in the retinal microvasculature as a result of a high concentration of glucose in the blood for a long time which generates numerous molecular changes like oxidative stress. Therefore, this narrative review aims to approach various biomarkers associated with the development of diabetic retinopathy. Focusing on the molecules showing promise as detection tools, among them we consider markers of oxidative stress (TAC, LPO, MDA, 4-HNE, SOD, GPx, and catalase), inflammation (IL-6, IL-1ß, IL-8, IL-10, IL-17A, TNF-α, and MMPs), apoptosis (NF-kB, cyt-c, and caspases), and recently those that have to do with epigenetic modifications, their measurement in different biological matrices obtained from the eye, including importance, obtaining process, handling, and storage of these matrices in order to have the ability to detect the disease in its early stages.

Metabolic Syndrome and Related Disorders

“…10 In addition, hyperhomocysteinemia was also reported to be associated with metabolic syndrome, obesity, insulin resistance, and inflammation. [11][12][13] Recent advances have demonstrated that there is a close link between hyperhomocysteinemia and several types of common cancers. [14][15][16][17] However, to our best knowledge, no report on the relationship between homocysteine and thyroid nodule prevalence has been published.…”

Section: Introductionmentioning

confidence: 99%

The Association Between Hyperhomocysteinemia and Thyroid Nodule Prevalence in an Adult Population

Qin

Wang

2020

Background: Thyroid nodule is the most common disorder of thyroid. Metabolic syndrome was regarded as an important factor for the prevalence of thyroid nodule. Homocysteine has been shown to be related to metabolic syndrome, inflammation, and several common cancers. In this study, we aimed to investigate the relationship between serum homocysteine and the prevalence of thyroid nodule. Materials and Methods: This was a cross-sectional study that included 2040 adults in a health checkup population in Beijing Chao-yang hospital. Thyroid ultrasound data, together with anthropometric characteristics, metabolic parameters, and serum homocysteine, were recorded respectively. Results: Hyperhomocysteinemia (defined as serum homocysteine ‡15 mmol/L) was detected in 452 participants (21.91%). Thyroid nodule prevalence was significantly higher in hyperhomocysteinemia participants than in normal homocysteine participants (52.57% vs. 45.16%, P = 0.006). Logistic regression analysis revealed that age [odds ratio (OR) 1.054; P < 0.001], female gender (OR 2.242; P < 0.001), body mass index (OR 1.050; P < 0.001), and serum homocysteine level (OR 1.022; P = 0.001) were the independent risk factors for thyroid nodule. Conclusions: Subjects with hyperhomocysteinemia have significantly higher thyroid nodule prevalence. Homocysteine is an independent risk factor for thyroid nodule. It implies that individuals with hyperhomocysteinemia have higher susceptibility to thyroid nodule.