Homocysteine is not associated with arterial thickness and stiffness in healthy middle-aged French volunteers

Bree, Angelika de; Mennen, Louise; Zureik, Mahmoud; Ducros, Véronique; Guilland, Jean-Claude; Nicolas, Jean‐Pierre; Emery-Fillon, Nathalie; Blacher, Jacques; Herçberg, Serge; Galán, Pilar

doi:10.1016/j.ijcard.2005.11.045

Cited by 27 publications

(21 citation statements)

References 44 publications

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“…26 On the other hand, de Bree et al conducted a similar crosssectional analysis and concluded that tHCY concentration was not associated with arterial stiffness. 27 In our study group, CIMT was significantly correlated with tHCY after adjustment for age and sex, which suggests that tHCY might be a marker relevant to atherosclerosis. However, we observed a complete lack of association of CAVI and C667T/MTHFR (data not shown), which suggests that careful elaboration is needed for the evaluation of HCY as a screening marker for atherosclerosis.…”

Section: Discussionmentioning

confidence: 47%

Availability of Cardio-Ankle Vascular Index (CAVI) as a Screening Tool for Atherosclerosis

Kadota

Takamura

Aoyagi

et al. 2008

Circ J

115

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Section: Discussionmentioning

confidence: 47%

Availability of Cardio-Ankle Vascular Index (CAVI) as a Screening Tool for Atherosclerosis

Kadota

Takamura

Aoyagi

et al. 2008

Circ J

115

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“…12,14 The fact that other studies observed a significant association between tHcy levels and PWV is probably due to the fact that those studies were performed in subjects who were at a markedly increased risk of cardiovascular events. 11,27,28 Two other studies reported that acute rises in tHcy after oral methionine caused increased aortic stiffness.…”

Section: Discussionmentioning

confidence: 99%

“…However, in the general population findings are still inconclusive. [12][13][14] Atherosclerosis may be another pathway by which tHcy is linked with arterial disease. In general, the evidence of a relationship between tHcy levels and CIMT as a measure of generalized atherosclerosis varies, with some studies reporting this association [15][16][17][18] while others do not.…”

Section: Introductionmentioning

confidence: 99%

“…In general, the evidence of a relationship between tHcy levels and CIMT as a measure of generalized atherosclerosis varies, with some studies reporting this association [15][16][17][18] while others do not. 12,14,[19][20][21] To gain more insight into the association of circulating tHcy with PWV and CIMT, we studied their associations in a population-based sample of 376 men.…”

Section: Introductionmentioning

confidence: 99%

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Circulating homocysteine and large arterial stiffness and thickness in a population-based sample of middle-aged and elderly men

et al. 2007

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Elevated plasma homocysteine (tHcy) is considered as a risk factor for cardiovascular events, and has been associated with arterial stiffness and subclinical atherosclerosis in subjects with classical cardiovascular risk factors. The aim of this study is to investigate the association of plasma tHcy with functional and structural changes in the large arteries by measuring aortic pulsewave velocity (PWV) and carotid artery intima-media thickness (CIMT). In a population-based sample of 376 middle-aged and elderly men, tHcy levels were measured by using fluorescence polarization immunoassay. Aortic stiffness was assessed non-invasively by measuring carotid-femoral PWV with the use of applanation tonometry. CIMT was measured by ultrasonography. We used multivariate linear regression analysis with the logtransformed value of tHcy as the determinant, and aortic PWV and CIMT as outcomes. In the univariate model, PWV increased with increasing tHcy concentration; PWV increased by 2.64 m/s (95% confidence interval (CI) 1.74; 3.54) per unit change in log tHcy. After adjustment for confounders, no statistically significant association remained; PWV increased by 0.42 m/s (95% CI À0.27; 1.11) per unit change in log tHcy. Furthermore, in the univariate model, CIMT increased significantly with increasing tHcy concentration; CIMT increased by 0.19 mm (95% CI 0.11; 0.26) per unit increase log tHcy. This association was attenuated and did not remain significant after additional adjustment for age and cardiovascular confounders (b ¼ 0.06 (95% CI À0.01; 0.13)). The results of this study do not support the presence of an independent relationship between circulating tHcy levels and large artery stiffness and thickness.

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“…There have been several cross-sectional studies regarding the relationship between cardiorespiratory fitness and homocysteine status. These factors were reported to be independent regardless of sex (10) or to be negatively associated in women but not in men (19). Therefore, genetic variations in MTHFR, such as C677T polymorphism, may influence the effects of regular exercise and plasma homocysteine status on arterial stiffness.…”

mentioning

confidence: 99%

Lack of carotid stiffening associated with MTHFR 677TT genotype in cardiorespiratory fit adults

Iemitsu

Murakami

Sanada

et al. 2010

Physiological Genomics

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The TT genotype of C677T polymorphism in 5,10-methylenetetrahydrofolate reductase (MTHFR) induces elevation of homocysteine level and leads to atherosclerosis and arterial stiffening. Furthermore, cardiorespiratory fitness level is also associated with arterial stiffness. In the present study, a cross-sectional investigation of 763 Japanese men and women (18 -70 yr old) was performed to clarify the effects of cardiorespiratory fitness on the relationship between arterial stiffness and MTHFR C677T gene polymorphism. Arterial stiffness was assessed by carotid ␤-stiffness with ultrasonography and tonometry. The study subjects were divided into high-cardiorespiratory fitness (HighFit) and low-cardiorespiratory fitness (Low-Fit) groups based on the median value of peak oxygen uptake in each sex and decade. The plasma homocysteine level was higher in the TT genotype of MTHFR C677T polymorphism compared with CC and CT genotype individuals. MTHFR C677T polymorphism showed no effect on carotid ␤-stiffness, but there was a significant interaction effect between fitness and MTHFR C677T polymorphism on carotid ␤-stiffness (P ϭ 0.0017). In the Low-Fit subjects, carotid ␤-stiffness was significantly higher in individuals with the TT genotype than the CC and CT genotypes. However, there were no such differences in High-Fit subjects. In addition, ␤-stiffness and plasma homocysteine levels were positively correlated in Low-Fit subjects with the TT genotype (r ϭ 0.71, P Ͻ 0.0001), but no such correlations were observed in High-Fit subjects. In CC and CT genotype individuals, there were also no such correlations in either fitness level. These results suggest that the higher cardiorespiratory fitness may attenuate central artery stiffening associated with MTHFR C677T polymorphism. peak oxygen uptake; arterial stiffness; homocysteine; 5,10-methylenetetrahydrofolate reductase ELEVATED PLASMA HOMOCYSTEINE level is considered a risk factor for cardiovascular events and is associated with arterial stiffness and atherosclerosis in subjects with some cardiovascular risk factors (7,15,30,36). High homocysteine levels may impair endothelial function, increase oxidative stress, and alter protein structure (5, 6, 37). Exposure of endothelial cells to elevated homocysteine levels results in decreased availability of nitric oxide (NO), which has vasodilatory and antiplatelet effects, and impaired vascular function, which are early events in atherogenesis (6,29,33,35). Homocysteine metabolism represents an interesting model of gene-environment interaction (34,38). Elevations in homocysteine may be caused by genetic and environmental factors and by gene-gene and/or geneenvironment interactions. The enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) catalyzes the irreversible conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate (4). A polymorphism of C677T (Ala¡Val) in the gene encoding MTHFR is associated with decreased activity of the enzyme due to thermolability (1). In individuals homozygous for the T (Val) allele, a r...

show abstract

Homocysteine is not associated with arterial thickness and stiffness in healthy middle-aged French volunteers

Cited by 27 publications

References 44 publications

Availability of Cardio-Ankle Vascular Index (CAVI) as a Screening Tool for Atherosclerosis

Availability of Cardio-Ankle Vascular Index (CAVI) as a Screening Tool for Atherosclerosis

Circulating homocysteine and large arterial stiffness and thickness in a population-based sample of middle-aged and elderly men

Lack of carotid stiffening associated with MTHFR 677TT genotype in cardiorespiratory fit adults

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