2004
DOI: 10.1056/nejmoa032546
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Homocysteine Levels and the Risk of Osteoporotic Fracture

Abstract: An increased homocysteine level appears to be a strong and independent risk factor for osteoporotic fractures in older men and women.

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Cited by 671 publications
(454 citation statements)
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References 30 publications
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“…In 2004, two landmark studies performed in the Netherlands and the USA produced consistent findings in terms of the magnitude of increased risk of fracture associated with mild elevations in homocysteine (36,37) . In subsequent years, further studies from the USA, the Netherlands and Norway similarly demonstrated increases in fracture risk associated with elevated homocysteine concentrations (31)(32)(33)35) .…”
Section: Evidence From Observational Studiesmentioning
confidence: 91%
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“…In 2004, two landmark studies performed in the Netherlands and the USA produced consistent findings in terms of the magnitude of increased risk of fracture associated with mild elevations in homocysteine (36,37) . In subsequent years, further studies from the USA, the Netherlands and Norway similarly demonstrated increases in fracture risk associated with elevated homocysteine concentrations (31)(32)(33)35) .…”
Section: Evidence From Observational Studiesmentioning
confidence: 91%
“…Indeed, Van Meurs et al (36) found a significant increase in fracture risk associated with the highest (compared with the lowest) quartile of homocysteine concentrations, but no significant differences in BMD values across homocysteine quartiles. Conversely, some studies have found an association of B-vitamin biomarkers with BMD but not with fracture risk.…”
Section: Evidence From Observational Studiesmentioning
confidence: 98%
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“…1 Hyperhomocysteinemia has also been linked to increased risk of Alzheimer's disease, 2 neural tube defects, 3 complications during pregnancy, 4 inflammatory bowel disease, 5 and osteoporosis. 6 The role of Hcy in disease is unclear. After many years of study and impressive progress, it is still not yet known if Hcy causes disease, is a consequence of it, or is simply a biomarker.…”
Section: Homocysteine and Cysteine In Human Healthmentioning
confidence: 99%
“…Several studies have reported that low plasma B 12 levels are associated with reduced bone quality [5,8,9,13,14], but this relation has not been observed by others [15][16][17]. More consistently, however, are the observations that increased Hcy may be a predictive factor for fracture risk [13][14][15][18][19][20][21]. Also, elevated MMA levels have been associated with osteoporosis in the elderly [14] and low bone mineral density (BMD) in adolescents [6].…”
mentioning
confidence: 99%