Homocysteine reduction by B‐vitamin supplementation increases t‐PA and PAI‐1 levels in patients with venous thromboembolism

Rodrigues, Caroline Fabri Bittencourt; Morelli, Vânia M.; Silveira, Raniely Casimiro da; D’Almeida, Vânia; Lourenço, Dayse Maria

doi:10.1111/j.1538-7836.2006.02269.x

Cited by 2 publications

(2 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thrombus is caused by blood solidification and abnormal viscosity due to obstacles affecting its fluidity; this results in the formation of thrombocytes and activation of blood coagulation factor ( 8 – 10 ). DVT is one of the results where abnormal hemorheology and viscosity induce ischemia and anoxia of organs ( 11 – 13 ).…”

Section: Discussionmentioning

confidence: 99%

Different doses of folic acid and vitamin B12 to treat rabbits with deep venous thrombosis and hyperhomocysteinemia

Shu

Chang

et al. 2018

Exp Ther Med

View full text Add to dashboard Cite

The effects of different doses of folic acid and vitamin B12 on rabbits with deep vein thrombosis (DVT) and hyperhomocysteinemia were investigated. In total, 60 New Zealand rabbits were divided into untreated control, low-dose and high-dose groups. After inducing DVT, hemorheology and coagulation indexes were measured 3 and 10 days later. We found that both treatment groups performed better than the control group, and the high-dose performed better than the low-dose. Ten days after thrombosis, the levels of Hcy and D-dimer were lower in the high-dose group. Moreover, the changes of lower extremity deep venous thrombosis were significantly reduced in both high- and low-dose groups, but the high-dose group showed the most improvement. The effective rate of the high-dose group was 100%, higher than the rate in the low-dose and control groups. Overall, high-dose of folic acid and vitamin B12 can significantly improve plasma Hcy, coagulation indexes, and pathological changes in the venous thrombosis of the lower extremity.

show abstract

Section: Discussionmentioning

confidence: 99%

Different doses of folic acid and vitamin B12 to treat rabbits with deep venous thrombosis and hyperhomocysteinemia

Shu

Chang

et al. 2018

Exp Ther Med

View full text Add to dashboard Cite

show abstract

“…Hcy reduction by B-vitamin supplementation increases tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) levels in patients with VTE [49]. Hyperhomocysteinemia is a risk factor for arterial and venous thrombosis [50].…”

Section: Homocysteine and Folatementioning

confidence: 99%

Review: Nutriceuticals as Antithrombotic Agents

Chakrabarti

Freedman

2010

Cardiovascular Therapeutics

View full text Add to dashboard Cite

Thrombus formation in a disrupted endothelium is influenced not only by the platelet redox state and reactive oxygen and nitrogen species but also by the presence of endogenous or exogenous antioxidants. Thrombus formation in the stenotic arteries is triggered predominantly by attenuated shear stress. Superoxide and nitric oxide production, as well as their metabolism, potentially influence platelet activation and thrombosis. Antioxidant supplementation has not been generally associated with better cardiovascular outcome and is often compounded by bleeding and hemorrhagic stroke. Because of recent developments like the human genome project and personalized medicine, an emerging new area of nutrigenomics and nutraceuticals offers a scientific approach of diet‐based therapeutics applicable to a plethora of human diseases, including cardiovascular inflammation and thrombosis. Therefore, further mechanistic research using nutragenomics and nutraceuticals in the prevention and management of thrombosis offers great potential and may be effective in limiting the problems associated with antioxidant‐based therapeutics. In the present review, we have summarized the effect of dietary antioxidants in the modulation of platelet‐mediated thrombosis. In addition, therapeutic opportunities in the area of nutragenomics and nutraceuticals in vascular and nonvascular diseases are also discussed.

show abstract

Homocysteine reduction by B‐vitamin supplementation increases t‐PA and PAI‐1 levels in patients with venous thromboembolism

Cited by 2 publications

References 18 publications

Different doses of folic acid and vitamin B12 to treat rabbits with deep venous thrombosis and hyperhomocysteinemia

Different doses of folic acid and vitamin B12 to treat rabbits with deep venous thrombosis and hyperhomocysteinemia

Review: Nutriceuticals as Antithrombotic Agents

Contact Info

Product

Resources

About