Homocysteine, Vitamin B12, and Folic Acid in Age-Related Macular Degeneration

Nowak, Mariusz; Świętochowska, Elżbieta; Wielkoszyński, Tomasz; Marek, Bogdan; Kos–Kudła, Beata; Szapska, Bożena; Kajdaniuk, Dariusz; Głogowska-Szeląg, Joanna; Siemińśka, Lucyna; Ostrowska, Zofia; Koziol, Helmut; Klimek, Jerzy

doi:10.1177/112067210501500617

Cited by 32 publications

(23 citation statements)

References 26 publications

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“…These findings indicate an association of markers of angiogenesis, hemostasis, and endothelial dysfunction with AMD. This hypothesis is supported by the results of the study by Nowak et al (2005a), which reported an association between AMD and atherosclerosis. High levels of homocysteine result in direct vascular endothelial injury by releasing free radicals, inhibiting glutathione peroxidase and nitric oxide, interfering with clotting factors and lipid peroxidation, all of which modify the vessel wall (Genser et al 2006;Papandreou et al 2006).…”

supporting

confidence: 81%

Decreased Serum Paraoxonase 1 Activity and Increased Serum Homocysteine and Malondialdehyde Levels in Age-Related Macular Degeneration

Ateş

Azizi

Hakan

et al. 2009

Tohoku J. Exp. Med.

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supporting

confidence: 81%

Decreased Serum Paraoxonase 1 Activity and Increased Serum Homocysteine and Malondialdehyde Levels in Age-Related Macular Degeneration

Ateş

Azizi

Hakan

et al. 2009

Tohoku J. Exp. Med.

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“…Homocysteine has been suggested as a biomarker of cardiovascular disease (Boushey et al, 1995). Additionally, studies not only found that homocysteine was significantly elevated in AMD patients (Kamburoglu et al, 2006; Rochtchina et al, 2007; Vine et al, 2005) but that the levels were higher in nvAMD vs. the dry form of AMD (Coral et al, 2006; Ghosh et al, 2013; Nowak et al, 2005). Although these data may support using serum homocysteine levels as a surrogate marker and screening for AMD, the studies had small numbers of cohorts yielding low statistical power.…”

Section: Biomarkers Of Disease and Progressionmentioning

confidence: 99%

Risk factors and biomarkers of age-related macular degeneration

Lambert

Elshelmani

Singh

et al. 2016

Progress in Retinal and Eye Research

291

240

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A biomarker can be a substance or structure measured in body parts, fluids or products that can affect or predict disease incidence. As age-related macular degeneration (AMD) is the leading cause of blindness in the developed world, much research and effort has been invested in the identification of different biomarkers to predict disease incidence, identify at risk individuals, elucidate causative pathophysiological etiologies, guide screening, monitoring and treatment parameters, and predict disease outcomes. To date, a host of genetic, environmental, proteomic, and cellular targets have been identified as both risk factors and potential biomarkers for AMD. Despite this, their use has been confined to research settings and has not yet crossed into the clinical arena. A greater understanding of these factors and their use as potential biomarkers for AMD can guide future research and clinical practice. This article will discuss known risk factors and novel, potential biomarkers of AMD in addition to their application in both academic and clinical settings.

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“…Recent cross-sectional (17–19) and case-control (20–24) studies indicate a direct association between homocysteine concentration in the blood and risk of AMD, suggesting that homocysteine may be a modifiable risk factor for AMD. Homocysteine is an intermediary amino acid formed during the metabolism of methionine, an essential amino acid derived from protein (25).…”

Section: Introductionmentioning

confidence: 99%

Folic Acid, Pyridoxine, and Cyanocobalamin Combination Treatment and Age-Related Macular Degeneration in Women

Christen¹,

Glynn²,

Chew³

et al. 2009

Arch Intern Med

151

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Context Observational epidemiologic studies indicate a direct association between homocysteine concentration in the blood and risk of age-related macular degeneration (AMD), but randomized trial data to examine the effect of homocysteine-lowering in AMD are lacking. Objective To examine incidence of AMD in a trial of folic acid/vitamin B6/vitamin B12. Design Randomized, double-masked, placebo-controlled trial. Participants 5,442 female health professionals aged 40 years or older with preexisting cardiovascular disease (CVD) or 3 or more CVD risk factors. A total of 5,205 of these women did not have a diagnosis of AMD at baseline and were included in this analysis. Intervention Participants were randomly assigned to receive a combination of folic acid (2.5 mg/d), vitamin B6 (50 mg/d), and vitamin B12 (1 mg/d), or placebo. Main Outcome Measures Total AMD, defined as a self-report documented by medical record evidence of an initial diagnosis after randomization, and visually-significant AMD, defined as confirmed incident AMD with visual acuity of 20/30 or worse attributable to this condition. Results After an average of 7.3 years of treatment and follow-up, there were 55 cases of AMD in the folic acid/B6/B12 group and 82 in the placebo group (relative risk [RR], 0.66; 95% confidence interval [CI], 0.47–0.93; p=0.02). For visually-significant AMD, there were 26 cases in the folic acid/B6/B12 group and 44 in the placebo group (RR, 0.59; 95% CI, 0.36–0.95; p=0.03). Conclusions These randomized trial data from a large cohort of women at high risk of CVD indicate that daily supplementation with folic acid/B6/B12 may reduce the risk of AMD.

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Homocysteine, Vitamin B12, and Folic Acid in Age-Related Macular Degeneration

Abstract: Hyperhomocysteinemia might be one of the risk factors for the exudative form of ARMD.

Cited by 32 publications

References 26 publications

Decreased Serum Paraoxonase 1 Activity and Increased Serum Homocysteine and Malondialdehyde Levels in Age-Related Macular Degeneration

Decreased Serum Paraoxonase 1 Activity and Increased Serum Homocysteine and Malondialdehyde Levels in Age-Related Macular Degeneration

Risk factors and biomarkers of age-related macular degeneration

Folic Acid, Pyridoxine, and Cyanocobalamin Combination Treatment and Age-Related Macular Degeneration in Women

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