Homocysteinemia After Hypertensive Pregnancy Disorders at Term

Visser, Sanne; Hermes, Wietske; Blom, Henk J.; Heijboer, Annemieke C.; Franx, Arie; Pampus, Maria G. van; Bloemenkamp, Kitty W. M.; Koopmans, Corine M.; Mol, Ben Willem J.; Groot, Christianne de

doi:10.1089/jwh.2015.5201

Cited by 3 publications

(3 citation statements)

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“…This finding may support previous findings of other groups that GH and/or PE (merged together as gestational hypertensive disorders or studied separately) are more likely to be associated with postpartum higher BMI [21,22,23,24,25,26,27,28,29], waist circumferences [21,26,30], systolic blood pressure [21,22,26,27,28,29,31,32], diastolic blood pressure [21,22,26,27,28,29,31,32,33], an increased cardiovascular risk over the next ten years [22,29,34,35,36,37], or an increased cardiovascular risk over the next 30 years [22,38] assessed by using a modified Framingham risk score or NORRISK 2 (a Norwegian risk model for acute cerebral stroke and myocardial infarction.…”

Section: Discussionsupporting

confidence: 90%

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Maternal Cardiovascular Risk Assessment 3-to-11 Years Postpartum in Relation to Previous Occurrence of Pregnancy-Related Complications

Hromadníková

Dvořáková

Krofta

2019

JCM

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The aim of the present study was to assess the long-term outcomes of women 3-to-11 years postpartum in relation to the previous occurrence of pregnancy-related complications such as gestational hypertension (GH), preeclampsia (PE) and fetal growth restriction (FGR). Body mass index (BMI), waist circumference values, the average values of systolic (SBP) and diastolic (DBP) blood pressures and heart rate, total serum cholesterol levels, serum HDL (high-density lipoprotein) cholesterol levels, serum LDL (low-density lipoprotein) cholesterol levels, serum triglycerides levels, serum lipoprotein A levels, serum CRP (C-reactive protein) levels, plasma homocysteine levels, serum uric acid levels, individual and relative risks of having a heart attack or stroke over the next ten years were compared between groups (50 GH, 102 PE, 34 FGR and 90 normal pregnancies) and correlated with the severity of the disease with regard to clinical signs (25 PE without severe features, 77 PE with severe features), and delivery date (36 early PE, 66 late PE). The adjustment for potential covariates was made, where appropriate. At 3–11 years follow-up women with a history of GH, PE regardless of the severity of the disease and the delivery date, PE without severe features, PE with severe features, early PE, and late PE had higher BMI, waist circumferences, SBP, DBP, and predicted 10-year cardiovascular event risk when compared with women with a history of normotensive term pregnancy. In addition, increased serum levels of uric acid were found in patients previously affected with GH, PE regardless of the severity of the disease and the delivery date, PE with severe features, early PE, and late PE. Higher serum levels of lipoprotein A were found in patients previously affected with early PE. The receiver operating characteristic (ROC) curve analyses were able to identify a substantial proportion of women previously affected with GH or PE with a predisposition to later onset of cardiovascular diseases. Women with a history of GH and PE represent a risky group of patients that may benefit from implementation of early primary prevention strategies.

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Section: Discussionsupporting

confidence: 90%

“…However, controversial results on serum biomarkers were reported in patients with a history of pregnancy-related complications. Some studies demonstrated altered levels of serum lipids [22,24,28,53], CRP [22,55] or homocysteine [32,56] in women with a prior exposure to gestational hypertensive disorders.…”

Section: Discussionmentioning

confidence: 99%

Maternal Cardiovascular Risk Assessment 3-to-11 Years Postpartum in Relation to Previous Occurrence of Pregnancy-Related Complications

Hromadníková

Dvořáková

Krofta

2019

JCM

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“…38,42,44,66,67 Three studies found higher levels in cases at 2.5, 8 years and decade(s) postpartum, although one study used a combined cohort of GH and PE, in which women self-reported making it less reliable. 56,68,69 Wu et al showed that cases with high Hcy levels have an increased arterial stiffness compared to cases with normal Hcy levels. 70 Finally, a meta-analysis pooling 390 cases and 342 controls showed higher Hcy levels in cases.…”

Section: Homocysteinementioning

confidence: 99%

Novel Cardiovascular Biomarkers Associated with Increased Cardiovascular Risk in Women With Prior Preeclampsia/HELLP Syndrome: A Narrative Review

2021

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Evidence has shown that women with a history of preeclampsia or haemolysis, elevated liver enzymes and low platelets (HELLP) syndrome have an increased risk of cardiovascular disease later in life. Recommendations for screening, prevention and management after such pregnancies are not yet defined. The identification of promising non-traditional cardiovascular biomarkers might be useful to predict which women are at greatest risk. Many studies are inconsistent and an overview of the most promising biomarkers is currently lacking. This narrative review provides an update of the current literature on circulating cardiovascular biomarkers that may be associated with an increased cardiovascular disease risk in women after previous preeclampsia/HELLP syndrome. Fifty-six studies on 53 biomarkers were included. From the summary of evidence, soluble fms-like tyrosine kinase-1, placental growth factor, interleukin (IL)-6, IL-6/IL-10 ratio, high-sensitivity cardiac troponin I, activin A, soluble human leukocyte antigen G, pregnancy-associated plasma protein A and norepinephrine show potential and are interesting candidate biomarkers to further explore. These biomarkers might be potentially eligible for cardiovascular risk stratification after preeclampsia/HELLP syndrome and may contribute to the development of adequate strategies for prevention of hypertension and adverse events in this population.

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Association between Homocysteine and Arterial Stiffness in Women with a History of Preeclampsia

Yang

Liu

2019

J Vasc Res

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Growing evidence has reported that a history of preeclampsia (PE) increases the risk of developing cardiovascular disease (CVD). Arterial stiffness plays a predictive role in CVD. Previous studies have demonstrated the close association between homocysteine (Hcy) level and arterial stiffness in community-based populations. This study was to assess whether Hcy level was independently associated with arterial stiffness in 168 women with a PE history who were analyzed at a 5-year follow-up. Brachial-ankle pulse wave velocity (baPWV) was measured by an automatic pulse-wave analyzer and a value >1,400 cm/s was defined as high arterial stiffness. Biochemical parameters were recorded and an Hcy value >10 μmol/L was defined as having hyperhomocysteine (H-Hcy). Variables that were significantly associated with baPWV were tested for independence by multivariate logistic regression analysis. We found that body mass index (OR 1.017, 95% CI 1.008–1.029), systolic blood pressure (OR 1.048, 95% CI 1.019–1.072), total cholesterol (OR 1.059, 95% CI 1.007–1.086), and Hcy level (OR 1.021, 95% CI 1.010–1.037) were independent determinants of baPWV in women with previous PE. Our findings indicate that Hcy pathway might be involved in arterial stiffness in women with a PE history. Whether Hcy would be a promising biomarker for serial stratified CVD risk management in these women deserves further evaluation on a large scale.

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Homocysteinemia After Hypertensive Pregnancy Disorders at Term

Cited by 3 publications

References 46 publications

Maternal Cardiovascular Risk Assessment 3-to-11 Years Postpartum in Relation to Previous Occurrence of Pregnancy-Related Complications

Maternal Cardiovascular Risk Assessment 3-to-11 Years Postpartum in Relation to Previous Occurrence of Pregnancy-Related Complications

Novel Cardiovascular Biomarkers Associated with Increased Cardiovascular Risk in Women With Prior Preeclampsia/HELLP Syndrome: A Narrative Review

Association between Homocysteine and Arterial Stiffness in Women with a History of Preeclampsia

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