Homocystine Levels, Polymorphisms and the Risk of Ischemic Stroke in Young Asian Indians

Biswas, Arijit; Ranjan, Ratnesh; Meena, Arvind; Akhter, Muhammad Saleem; Yadav, Birendra Kumar; Munisamy, Murali; Subbiah, Vivekanandhan; Behari, Madhuri; Saxena, Renu

doi:10.1016/j.jstrokecerebrovasdis.2008.09.014

Cited by 45 publications

(43 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our study the C677T MTHFR polymorphism in healthy controls was 17.0%. Our study did not find any significant relation with stroke subgroups and these results are consistent with earlier findings reported by Szolnoki et al [29] A study on Asian Indians revealed an association of MTHFR C677T with hyperhomocysteinemia as well as stroke [16]. Homocysteine is a sulfur-containing amino acid formed in vivo from methionine derived from dietary protein.…”

Section: Discussionsupporting

confidence: 92%

“…Our study revealed no association of MTHFR C677T polymorphism in ischemic as well as hemorrhagic stroke patients of Northern India. However, in two previous Indian case-control studies, MTHFR C677T polymorphism was associated with ischemic stroke [15,16]. In one study, T allele of MTHFRC677T polymorphism was found to be an important risk factor but true only in younger patients [16].…”

Section: Discussionmentioning

confidence: 89%

“…However, in two previous Indian case-control studies, MTHFR C677T polymorphism was associated with ischemic stroke [15,16]. In one study, T allele of MTHFRC677T polymorphism was found to be an important risk factor but true only in younger patients [16]. The other study reported that MTHFR C677T-TT genotype was associated with ischemic stroke [17].…”

Section: Discussionmentioning

confidence: 98%

See 2 more Smart Citations

Evaluation of MTHFR C677T polymorphism in ischemic and hemorrhagic stroke patients. A case–control study in a Northern Indian population

Somarajan¹,

Kalita²,

Mittal³

et al. 2011

Journal of the Neurological Sciences

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Evaluation of MTHFR C677T polymorphism in ischemic and hemorrhagic stroke patients. A case–control study in a Northern Indian population

Somarajan¹,

Kalita²,

Mittal³

et al. 2011

Journal of the Neurological Sciences

View full text Add to dashboard Cite

“…Also we noticed an association of both TT genotype and T allele frequencies at +677 in diabetic Egyptian patients suffered from IS when compared to the controls and diabetic patients without IS. These findings were in harmony with other studies of Kissela et al, 2005, Goracy et al, 2009, Biswas et al, 2009and Moe et al, 2008 In an effort to determine the functional relevance of C677T MTHFR polymorphism, we examined the association of the genotype at +677 in MTHFR and Hcy plasma levels. We observed a significant increase in Hcy plasma levels in diabetic patient groups when compared to controls with more increase in diabetic patients with IS.…”

Section: Discussionsupporting

confidence: 83%

Methylene Tetrahydrofolate Reductase Gene Polymorphism and the Risk of Ischemic Stroke in Type 2 Diabetic Egyptian Patients

Mackawy¹,

Badawy²

2011

GJHS

View full text Add to dashboard Cite

Background: A common C677T mutation of methylenetetrahydrofolate reductase (MTHFR) gene is reported to be associated with hyperhomocysteinemia a risk for atherosclerotic vascular diseases and ischemic stroke (IS). Aim: To clarify the possible role of the MTHFR 677C>T polymorphism in predisposition to IS and to assess the relationship of allelic variants of MTHFR gene with homocysteine (Hcy) plasma levels and other risk factors of atherosclerosis and IS in type 2 diabetic Egyptians. Subjects: Group I: 40 healthy non diabetic volunteers. Group II: 40 patients with type 2 diabetes mellitus (DM) without IS. Group III: 40 patients with type 2 DM and IS. Methods: Fasting blood samples were collected for research investigations. HPLC technique was used to estimate plasma Hcy levels. Polymerase chain reaction (PCR) assay with restriction fragment length polymorphism (RFLP) were used to examine the MTHFR polymorphism. Results: The frequencies of T allele and TT genotype were significantly higher in group III patients when compared to group I and group II (P<0.001) .Total plasma Hcy and uric acid levels were significantly higher in group III patients who carry the TT genotype. Conclusion: The MTHFR 677C>T polymorphism is associated with elevated Hcy and uric acid plasma levels which increases the atherogenic risk and the prevalence of IS in type 2 diabetic Egyptian patients.

show abstract

“…Individuals with a nutritional deficiency are at risk of developing hyperhomocysteinemia [3]. It was suggested that about two-thirds of hyperhomocysteinemia in an elderly population in the United States resulted from inadequate blood concentrations of the vitamins [4,5].…”

Section: Introductionmentioning

confidence: 99%

A Community Based Study of the Relationship Between Homocysteine and Some of the Life Style Factors

Das¹,

Ghose²,

Borah³

et al. 2010

Indian J Clin Biochem

View full text Add to dashboard Cite

Till date no community based data on plasma homocysteine is available in North Eastern Region. Hence, the present study was conducted to analyze and correlate the plasma homocysteine level with some life style factors like diet, alcohol intake, smoking habit and body weight, in a cross-section of population. 12 h fasting samples of 970 apparently healthy, Assamese population of both genders in the age group of 35-86 years, mostly from the urban area of Assam were tested for plasma total homocysteine level over a period of 3 years. Out of 970 volunteers, hyperhomocysteinemia was detected in 533 (55%) individuals with a mean value of 18.41 lmol/l. Of that hyperhomocysteinemia, 89.1% were in the range of moderately high and rest 10.9% were intermediate high. Another finding was that males had a tendency towards greater value (mean = 20.36 lmol/l) than females (mean = 16.37 lmol/l). It was observed that the relationship of homocysteine levels to gender and some of the life style factors were also significant.

show abstract

Homocystine Levels, Polymorphisms and the Risk of Ischemic Stroke in Young Asian Indians

Cited by 45 publications

References 36 publications

Evaluation of MTHFR C677T polymorphism in ischemic and hemorrhagic stroke patients. A case–control study in a Northern Indian population

Evaluation of MTHFR C677T polymorphism in ischemic and hemorrhagic stroke patients. A case–control study in a Northern Indian population

Methylene Tetrahydrofolate Reductase Gene Polymorphism and the Risk of Ischemic Stroke in Type 2 Diabetic Egyptian Patients

A Community Based Study of the Relationship Between Homocysteine and Some of the Life Style Factors

Contact Info

Product

Resources

About