Homogeneous probing of lipase and α-amylase simultaneously by AIEgens

Shi, Jie; Deng, Qianchun; Wang, Yongdong; Zheng, Zhe; Shangguan, Huijuan; Li, Lü; Huang, Fenghong; Tang, Bo

doi:10.1039/c9cc01959f

Cited by 19 publications

(19 citation statements)

References 28 publications

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“…36 This indicated that the lipase enzyme was able to diffuse into the film and retained its catalytic activity. Since an abnormally high level of lipase features a condition known as acute pancreatitis, 37 which imposes a severe threat to people's lives, the PNPP-doped film is promising for easy detection of the degree of lipase activity in a clinical setting.…”

Section: Resultsmentioning

confidence: 99%

Pressing-Induced Caking: A General Strategy to Scale-Span Molecular Self-Assembly

et al. 2020

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General strategies leading to scale-span molecular self-assembly are of crucial importance in creating bulk supramolecular materials. Here, we report that under mechanical pressure, caking of the precipitated molecular self-assemblies led to bulk supramolecular films. Massive fabrication of supramolecular films became possible by employing a simple household noodle machine. The film could be endowed to acquire diversified functions by depositing various functional ingredients via coprecipitation. We expect that our current work opens up a new paradigm leading to large-scale functional solid molecular self-assembled materials.

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Section: Resultsmentioning

confidence: 99%

Pressing-Induced Caking: A General Strategy to Scale-Span Molecular Self-Assembly

et al. 2020

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“…Taking advantage of the restriction of cavities toward rotors of AIEgens, Tang's group constructed an AIE dual-reactive supramolecular probe based on TPE-modified γ-CD. [106] This supramolecular probe can be used in homogeneous probing of lipase and α-amylase, thereby enabling [8], PEG-Np, and PTPE, and their use as building blocks for the preparation of SNPs; B) schematic diagram of SNPs for application in imaging-guided drug delivery. A,B) Reproduced with permission.…”

Section: Cyclodexrinmentioning

confidence: 99%

“…Taking advantage of the restriction of cavities toward rotors of AIEgens, Tang's group constructed an AIE dual‐reactive supramolecular probe based on TPE‐modified γ‐CD. [ 106 ] This supramolecular probe can be used in homogeneous probing of lipase and α‐amylase, thereby enabling accurate diagnosis of diseases associated with the human digestive system.…”

Section: Supramolecular Macrocycle‐guided Assembly Via Host–guest Intmentioning

confidence: 99%

Nanomaterials with Supramolecular Assembly Based on AIE Luminogens for Theranostic Applications

et al. 2020

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health concerns across the world. [1] Particularly significant is the effort directed toward the treatment of cancer, which has remained as one of the leading causes of rapidly growing morbidity and mortality rates for centuries. Among a number of significant advances achieved in this domain, cancer theranostics is one such advancement that allows the ingenious integration of accurate diagnosis with therapeutic intervention in a single formulation within spatial colocalization. This phenomenon has captivated the interest of researchers for the evaluation of the potential in fundamental studies and clinical application, [2] primarily due to the attribution of various intrinsic advantages to theranostics, including maximized therapeutic efficacy, optimized drug safety, and improved pharmacokinetics. [3] Notably, in comparison with the conventional therapeutic methods for cancers such as surgical removal, chemotherapy, and radiotherapy, [4] theranostics involves some burgeoning therapeutic strategies including photothermal therapy (PTT), [5] photodynamic therapy (PDT), [6] and gene therapy. It has become one of the most intensive areas of research during recent years due to high efficiency, minimal side effects, excellent tumor suppression, and non-invasive conversion. One of the major pursuits of biomedical science is to develop advanced strategies for theranostics, which is expected to be an effective approach for achieving the transition from conventional medicine to precision medicine. Supramolecular assembly can serve as a powerful tool in the development of nanotheranostics with accurate imaging of tumors and real-time monitoring of the therapeutic process upon the incorporation of aggregation-induced emission (AIE) ability. AIE luminogens (AIEgens) will not only enable fluorescence imaging but will also aid in improving the efficacy of therapies. Furthermore, the fluorescent signals and therapeutic performance of these nanomaterials can be manipulated precisely owing to the reversible and stimuli-responsive characteristics of the supramolecular systems. Inspired by rapid advances in this field, recent research conducted on nanotheranostics with the AIE effect based on supramolecular assembly is summarized. Here, three representative strategies for supramolecular nanomaterials are presented as follows: a) supramolecular self-assembly of AIEgens, b) the loading of AIEgens within nanocarriers with supramolecular assembly, and c) supramolecular macrocycle-guided assembly via host-guest interactions. Meanwhile, the diverse applications of such nanomaterials in diagnostics and therapeutics have also been discussed in detail. Finally, the challenges of this field are listed in this review.

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“…Inflammation induces a significant increase in α-amylase in blood under the conditions of pancreatic and sialaden injury. 37,38 More importantly, α-amylase can hydrolyze α-1,4 glycosidic bonds in carbohydrates, including cyclodextrins (CDs), 39 which provides a stimulus to control the fluorescence of AIEgens-cyclodextrin (CD) based hydrogels. Herein, by taking advantage of the host–guest recognition of TPE with γ-CD, an example of a self-healing hydrogel has been designed and derived from the host–guest interaction between TPE modified poly( l -glutamic acid) (PLGA–TPE) and acrylate γ-CD (Ac-γ-CD) under the assistance of chemical crosslinking.…”

Section: Introductionmentioning

confidence: 99%

Aggregation-induced emission luminogen based self-healing hydrogels fluorescent sensors for α-amylase

et al. 2022

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Homogeneous probing of lipase and α-amylase simultaneously by AIEgens

Abstract: An AIE dual-reactive supramolecular probe has been devised to simultaneously measure endogenous lipase and α-amylase activity in a homogeneous system. Fluorescence quantitative analysis of lipase and α-amylase in real biological samples enables rapid and accurate diagnosis of diseases.

Cited by 19 publications

References 28 publications

Pressing-Induced Caking: A General Strategy to Scale-Span Molecular Self-Assembly

Pressing-Induced Caking: A General Strategy to Scale-Span Molecular Self-Assembly

Nanomaterials with Supramolecular Assembly Based on AIE Luminogens for Theranostic Applications

Aggregation-induced emission luminogen based self-healing hydrogels fluorescent sensors for α-amylase

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