Homogenous distribution of fast response action potentials in canine pulmonary vein sleeves: a contradictory report

Wang, Tsui Min; Chiang, Chern En; Sheu, Joen Ron; Tsou, Chi Hsiang; Chang, Hsiu Ming; Luk, Hsiang Ning

doi:10.1016/s0167-5273(02)00474-6

Cited by 34 publications

(27 citation statements)

References 23 publications

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“…Multiple impalements were performed starting from the proximal end up to the distal end of the myocardial sleeves. Consistent with the results in our previous study [12], the action potentials at all sites of the PV sleeves were of the fast-response type. Neither spontaneous activity nor early and delayed after-depolarizations could be observed (0%, n=80).…”

Section: Resultssupporting

confidence: 91%

“…All action potentials recorded from each tissue specimen were fast-type response and comparable to atrial action potentials in APA, V max and APD [12]. They had a normal sensitivity and response in quality to drugs or beta-adrenergic and muscarinic agonists.…”

Section: Absence Of Automaticity Under Normal Conditionsmentioning

confidence: 83%

“…Recently, a series of papers showed a high incidence of pacemaker activities in PV sleeves from normal healthy dogs and rabbits, as well as early and delayed after-depolarizations in tissue preparations and isolated single myocytes [5][6][7][8][9]. In contrast to these arrhythmogenic properties in PVs, no spontaneous activity or triggered activity was ever observed by several independent research groups [10][11][12]. This major controversy in cellular electrophysiological properties of PV sleeves remains to be investigated.…”

Section: Introductionmentioning

confidence: 99%

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Inducibility of abnormal automaticity and triggered activity in myocardial sleeves of canine pulmonary veins

Wang

Luk

Sheu

et al. 2005

International Journal of Cardiology

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Section: Resultssupporting

confidence: 91%

Section: Absence Of Automaticity Under Normal Conditionsmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

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Inducibility of abnormal automaticity and triggered activity in myocardial sleeves of canine pulmonary veins

Wang

Luk

Sheu

et al. 2005

International Journal of Cardiology

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“…Comparisons of electrically stimulated action potentials in the left atrium and the pulmonary vein have given rise to variable results in different species (8,12,17,22,25,33). In our experimental conditions, there was no difference in the diastolic membrane potential during electrical stimulation at 2 Hz between what would be classed as "distal" pulmonary vein by Miyauchi et al (22) and left atrium, although action potential duration was greater in the pulmonary vein.…”

Section: Discussionmentioning

confidence: 58%

“…A depolarized membrane potential can lead to deterioration of electrically evoked action potential form and even inexcitability (33,35), probably due to inactivation of voltage-gated Na ϩ channels. We obtained similar results in the pulmonary vein in the presence of cirazoline.…”

Section: Discussionmentioning

confidence: 99%

Catecholaminergic automatic activity in the rat pulmonary vein: electrophysiological differences between cardiac muscle in the left atrium and pulmonary vein

Doisne¹,

Maupoil²,

Cosnay³

et al. 2009

American Journal of Physiology-Heart and Circulatory Physiology

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Doisne N, Maupoil V, Cosnay P, Findlay I. Catecholaminergic automatic activity in the rat pulmonary vein: electrophysiological differences between cardiac muscle in the left atrium and pulmonary vein. Am J Physiol Heart Circ Physiol 297: H102-H108, 2009. First published May 8, 2009 doi:10.1152/ajpheart.00256.2009.-Ectopic activity in cardiac muscle within pulmonary veins (PVs) is associated with the onset and the maintenance of atrial fibrillation in humans. The mechanism underlying this ectopic activity is unknown. Here we investigate automatic activity generated by catecholaminergic stimulation in the rat PV. Intracellular microelectrodes were used to record electrical activity in isolated strips of rat PV and left atrium (LA). The resting cardiac muscle membrane potential was lower in PV [Ϫ70 Ϯ 1 (SE) mV, n ϭ 8] than in LA (Ϫ85 Ϯ 1 mV, n ϭ 8). No spontaneous activity was recorded in PV or LA under basal conditions. Norepinephrine (10 Ϫ5 M) induced first a hyperpolarization (Ϫ8 Ϯ 1 mV in PV, Ϫ3 Ϯ 1 mV in LA, n ϭ 8 for both) then a slowly developing depolarization (ϩ21 Ϯ 2 mV after 15 min in PV, ϩ1 Ϯ 2 mV in LA) of the resting membrane potential. Automatic activity occurred only in PV; it was triggered at approximately Ϫ50 mV, and it occurred as repetitive bursts of slow action potentials. The diastolic membrane potential increased during a burst and slowly depolarized between bursts. Automatic activity in the PV was blocked by either atenolol or prazosine, and it could be generated with a mixture of cirazoline and isoprenaline. In both tissues, cirazoline (10 Ϫ6 M) induced a depolarization (ϩ37 Ϯ 2 mV in PV, n ϭ 5; ϩ5 Ϯ 1 mV in LA, n ϭ 5), and isoprenaline (10 Ϫ7 M) evoked a hyperpolarization (Ϫ11 Ϯ 3 mV in PV, n ϭ 7; Ϫ3 Ϯ 1 mV in LA, n ϭ 6). The differences in membrane potential and reaction to adrenergic stimulation lead to automatic electrical activity occurring specifically in cardiac muscle in the PV. atrium; norepinephrine; electrophysiology; atrial fibrillation; thoracic veins THE CAUSE OF FOCAL ELECTRICAL activity in myocardial sleeves within the pulmonary veins (6, 14) which can trigger and sustain atrial fibrillation in humans is unknown.A number of themes have been developed to address possible causes of ectopic activity in the pulmonary veins. An attractive but disputed hypothesis is that cardiac muscle in pulmonary veins contains pacemaker cells that would generate spontaneous activity (5, 24). Quantitative surveys of ion channel currents in isolated cardiac myocytes have looked for differences that might account for an increased tendency toward automatic activity in the pulmonary vein (1,12,21). Extensive studies have been made to determine whether cardiac muscle in pulmonary veins is more prone than the left atrium to develop arrhythmogenic phenomena such as early and delayed afterdepolarizations (EADs and DADs) due to differences in Ca 2ϩ handling and/or tachycardia-triggered activity (5, 34). The irregular orientation of cardiac muscle fibers in the pulmonary vein has been suggested to lead t...

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Electrophysiological Basis of Atrial Fibrillation

Verheule¹,

Brakel²,

Harks³

et al. 2008

Manual of Surgical Treatment of Atrial Fibrillation

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Homogenous distribution of fast response action potentials in canine pulmonary vein sleeves: a contradictory report

Cited by 34 publications

References 23 publications

Inducibility of abnormal automaticity and triggered activity in myocardial sleeves of canine pulmonary veins

Inducibility of abnormal automaticity and triggered activity in myocardial sleeves of canine pulmonary veins

Catecholaminergic automatic activity in the rat pulmonary vein: electrophysiological differences between cardiac muscle in the left atrium and pulmonary vein

Electrophysiological Basis of Atrial Fibrillation

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