Homoleptic and heteroleptic silver(I) complexes bearing diphosphane and thioamide ligands: Synthesis, structures, DNA interactions and antibacterial activity studies

Silver(i) complexes bearing heterocyclic thioamide ligands with NH2 and CF3 substituents: effect of ligand group substitution on antibacterial and anticancer properties

“…77 From these data the EB-DNA quenching constants k q were calculated (eqn (S3) †) and found to be >10 10 M −1 s −1 (Table S12 †), providing an indication that quenching of EB-DNA fluorescence induced by the three complexes occurs via a static mechanism that entails the formation of a new conjugate, i.e., compound/CT-DNA. 78 The relatively low K SV constants of the complexes (compared to the K SV constants reported of recently reported analogous Ag(I) complexes 43 ) together with the observed moderate emission quenching of the EB-DNA solution suggest the low efficacy of the three complexes for intercalation into CT-DNA 58 (at least in the low concentration range with r < 0.15).…”

“…The Ag-S bond length was found to be 2.647(1) Å, while the Ag-Cl bond length is at 2.612 (2) Å. Analogous bond lengths and angles are observed in similar Ag(I) complexes that have been reported in the literature. 34,43,59 The molecular structure of 1 is stabilized by an intramolecular hydrogen-bonding interaction between the halogen atom and the NH group of the heterocyclic ring of atdztH, which is evidenced by the relative orientation of thioamide ligand with respect to the halogen atom and the short NH⋯Cl distance (ca. 2.240 Å).…”

“…Considering the high biological efficacy of 1-3, we investigated their potential to interact with this biomolecule 69,70 and their mode of interaction. 43,44,71 The interaction of 1-3 with CT-DNA was initially studied by UV-Vis absorption spectroscopy. In particular, we followed the changes in specific UV absorption bands of the three complexes in DMSO solutions, upon addition of increasing amounts of CT-DNA.…”

“…38 We also recently reported a number of heteroleptic Ag(I) complexes bearing the thioamides 5-methyl-1,3,4-thiadiazole-2(3H)-thione (mtdztH), 2-pyrimidinethiol (pymtH), 4-phenyl-imidazole-2thione (phimtH) and 2,2,5,5-tetramethyl-imidazolidine-4-thione (tmimdtH) in combination with different phosphines, such as PPh 3 , bis[(2-diphenylphosphino)phenyl]ether (DPEphos), 4,5-bis (diphenylphosphino)-9,9-dimethylxanthene (xantphos), and 1,2bis(diphenylphosphino)ethane (dppe), which showed moderateto-high antibacterial properties and cytotoxicity, and revealed the impact of the thioamide nature on the observed bioactivity. 43,44 Aiming to extend our studies in this field, herein we present a series of Ag(I) complexes bearing a phosphine ligand in combination with a small size heterocyclic ring thioamide with highly electronegative substituents, i.e. 5-amino-1,3,4thiadiazole-2(3H)-thione (atdztH) and 4-methyl-5-(trifluoromethyl)-1,2,4-triazol-3-thiol (mtftH), and their in vitro antibacterial and anticancer activity assessment.…”

Polynuclear Silver(I) Complex with Thianthrene: Structural Characterization, Antimicrobial Activity and Interaction with Biomolecules

“…The critical factor in determining the antimicrobial activity of silver(I) complexes is the type of the ligand donor atom bound to the Ag(I) ion. In this respect, in the last few decades, research has been focusing on the synthesis of silver(I) complexes with sulfur-donor ligands, including mercaptan, thioamide and thione ligands [3]. In the present contribution, the chemistry of new silver(I) complex with thianthrene (tia), [Ag(NO3)(H2O)(tia)]n, is studied in solution and solid state using spectroscopic and crystallographic methods.…”