Homology analysis of 51 penicillin-intermediate <i>Streptococcus pneumoniae</i> isolates from Wenzhou City, China

Zhang, Jin; Hu, Dakang; Gao, Chunyan; Sui, Weiwei; Luo, Xinhua; Yu, Jiangnan; Li, Xiangyang; Jiang, Xiaolong; Zhu, Wushuang; Chen, Weiqing

doi:10.1177/0300060520919061

Cited by 2 publications

(1 citation statement)

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“…The nonsusceptibility rates of penicillin in bacteremia and meningitis isolates (1.3% and 65.9%) were lower than in a study conducted in Beijing China (8.5% and 71.9%) [ 16 ]. Consistent with many studies [ 47 – 49 ], S. pneumoniae in the present study is generally sensitive to vancomycin, linezolid, and levofloxacin, with 100% susceptibility. Erythromycin, clarithromycin, and azithromycin are the three most widely used macrolide antibiotics in the clinic.…”

Section: Discussionsupporting

confidence: 92%

Clinical Characteristics, Antimicrobial Resistance, and Outcomes of Patients with Invasive Pneumococcal Disease in Ningxia Hui Autonomous Region, China, 2013–2021

Jia

Wang

et al. 2022

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Objectives. This study aimed to analyze the clinical features, antibiotic susceptibility profiles, and outcomes of patients with invasive pneumococcal disease (IPD) at a hospital in Ningxia Hui Autonomous Region, to provide the basis for improving the clinical treatment effect. Methods. Patients with IPD were retrospectively collected from 2013 to 2021. Clinical manifestations, laboratory tests, antimicrobial susceptibility, antibiotic treatment, and outcomes of the disease were analyzed. Results. In this study, we identified 127 IPD cases, of whom 49 (38.6%) had meningitis and 78 (61.4%) had bacteremia. The median ages of pediatric cases and adult cases were 2 years (IQR: 0–5) and 52.5 years (IQR: 35–62), respectively. There were 27 and 45 males in the pediatric and adult groups, and no significant gender difference in the different age groups ( p = 0.584 ) was found. Of 75 cases with underlying diseases, pneumonia (11%), malignancy (11%), hypertension (9.4%), and hepatic cirrhosis (7.9%) were the most common. The incidence of underlying diseases was even higher in the adult group (67.1%) than in the pediatric group (47.1%) ( p = 0.028 ). The frequency of fever, cough, and seizures was significantly higher in the pediatric group than in the adult group, with p -values of 0.004, 0.004, and 0.001, respectively. The percentage of neutrophils in the blood was significantly higher in the adult cases than in the pediatric cases ( p < 0.001 ). Furthermore, there was a significantly higher WBC count ( p < 0.001 ), percentage of neutrophils ( p = 0.012 ), and protein level ( p = 0.019 ) in the CSF samples in the adult patients compared to pediatric patients. The susceptibility rates of S. pneumoniae isolates to vancomycin, linezolid, and levofloxacin were 100%. The susceptibility rates of penicillin were 98.7% and 34.1% in bacteremia and meningitis patients, respectively. Most isolates were resistant to erythromycin, clindamycin, tetracycline, and azithromycin. The most common antibiotic treatment was β-lactams. Seven (5.5%) patients died during hospitalization, and 38 (29.9%) patients' health deteriorated. Conclusion. These results may provide a reference basis for the diagnosis and empiric treatment of IPD in the region.

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Section: Discussionsupporting

confidence: 92%