Homophilic Peptide Inhibits Growth of Malignant Murine and Human B Cells

Abstract

A homophilic peptide from the T15 plasmacytoma inhibits growth of murine and human B cell tumors. This finding confirms the hypothesis that B cell malignancies are driven by a self-binding epitope in the B cell receoptor (BCR) proposed as the pathogenesis of chronic lymphocytic leukemia (CLL).