Homozygosity for the APOE E4 Allele is Solely Associated with Lower Cognitive Performance in Brazilian Community-dwelling Older Adults – The Bambuí Study

Quintino-Santos, Sandra Regina; Lima‐Costa, Maria Fernanda; Uchôa, Elizabeth; Firmo, Josélia Oliveira de Araujo; Moriguchi, Emílio Hideyuki; Castro-Costa, Érico

doi:10.1016/j.rbp.2012.06.005

Cited by 6 publications

(4 citation statements)

References 27 publications

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“…The human ApoE2, ApoE3, and ApoE4 alleles have worldwide frequencies of 8.4%, 77.9%, and 13.7%, respectively [16]. However, while the frequency of ApoE4 was 13.5% in an elderly Brazilian population [9], it was 8.7% in a community-dwelling Korean population [17]. Differences in the study subjects and methods used for ApoE genotyping may also have contributed to the variations in the reported prevalence rates of the ApoE4 genotype.…”

Section: Discussionmentioning

confidence: 99%

“…With regard to nondemented people, there is controversy about the association between risk factors for cognitive impairment and ApoE4. Some studies [7][8][9] have observed ApoE4-related deficits in cognitive performance, while control studies [10,11] have found no difference in the prevalence of ApoE4 between healthy controls and SCD groups.…”

Section: Introductionmentioning

confidence: 99%

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ApoE4 genotype and cognitive performance in Korean health examinees with subjective memory complaints: A retrospective cross-sectional study

Nah¹,

Cho²,

Kim³

et al. 2020

J Transl Sci

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Introduction: Subjective memory complaints are a natural phenomenon in the aging process. The apolipoprotein E epsilon 4 (ApoE4) allele is the strongest genetic risk factor for Alzheimer's disease. The aims of this study were to determine the distribution of the ApoE genotype and how the status of ApoE4 is associated with the cognitive function of Korean health examinees with subjective memory complaints. Methods:A retrospective cross-sectional study was conducted with 1,107 health examinees with subjective memory complaints who underwent both medical and cognitive testing including ApoE genotyping at two health-promotion centers in two Korean cities between 2016 and 2017. ApoE was genotyped using the Seeplex ApoE ACE Genotyping (Seegene, Seoul, Korea). Cognitive function was assessed using the K-MMSE. All of the subjects were classified according to the ApoE4 status into non-carriers, heterozygotes, and homozygotes. The odds ratios (ORs) were estimated using logistic regression for assessing the relationship between the ApoE4 genotype and cognitive impairment. ANOVA was used to compare the cognitive domain scores according to the ApoE4 status.Results: ApoE4 allele frequency was 10.6%. ApoE4 homozygosity was significantly associated with a lower K-MMSE score (≤23) (OR=4.651, 95% CI=1.287-16.812) compared to ApoE4 non-carriers, and this association remained after adjusting for age, sex, BMI, blood pressure, blood lipid, and glucose. The scores in the temporal orientation and recall domains were lower in ApoE4 heterozygotes than in ApoE4 non-carriers (P<0.05).Discussion: ApoE4 homozygosity was associated with cognitive impairment in health examinees with subjective memory complaints and ApoE4 allele selectively affects to temporal orentation and recall domains. exhibits a north-south gradient across European both healthy people and AD, being highest in the north and lowest in the south.The aims of this study were to determine the distribution of the ApoE genotype and how the status of ApoE4 is associated with the cognitive function of Korean health examinees with subjective memory complaints. Moreover, the cognitive domain scores were evaluated according to ApoE4 status. Methods SubjectsA retrospective cross-sectional study was conducted with 1,107 health examinees with subjective memory complaints who underwent both medical and cognitive testing including ApoE genotyping as part of a health checkup at two health-promotion centers in two Korean cities between January 2016 and December 2017. The exclusion criteria Nah E (2019) ApoE4 genotype and cognitive performance in Korean health examinees with subjective memory complaints: A retrospective cross-sectional study

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

ApoE4 genotype and cognitive performance in Korean health examinees with subjective memory complaints: A retrospective cross-sectional study

Nah¹,

Cho²,

Kim³

et al. 2020

J Transl Sci

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“…It is also important to point out that in this same population, the presence of ε4 allele is associated with lower cognitive performance 43 , but we considered cognitive functioning to be a confounding factor. In addition, it has been shown that the cognitive deficit is more strongly associated with the decline of IADL (which was not associated with apoE genotypes in this study) compared with BADL and mobility 18 , showing that other factors may modulate this association, besides cognitive decline 44 .…”

Section: Discussionmentioning

confidence: 99%

Apolipoprotein E polymorphism and functional disability in Brazilian elders: the Bambuí Health and Aging Study

et al. 2016

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“…Several other studies found ApoE∊4 could significantly affect MMSE score. 18,19 The MMSE is a roughly cognitive test used to screen dementia; it can’t measure the cognitive function accurately. Kim et al 20 examined 215 Korean individuals who were 65 years or older and didn’t find a significant effect of ApoE∊4 on MMSE score.…”

Section: Discussionmentioning

confidence: 99%

ApoE Type 4 Allele Affects Cognitive Function of Aged Population in Tianjin City, China

Sun

Fu²,

Chen

et al. 2015

Am J Alzheimers Dis Other Demen

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Apolipoprotein E type 4 allele (ApoE∊4) is known as a risk gene for the late-onset Alzheimer's disease, and the relationship between ApoE∊4 and cognitive function of the elderly people has drawn the attention of the scientists. In this study, we investigated the relationship between ApoE∊4 and the cognitive function of the old people. A total of 156 old people were investigated, of whom 31 were ApoE∊4 carriers. The ApoE∊4 primarily influenced the global cognitive function, perceptual speed, and work memory. The results indicate that ApoE∊4 has significant negative effect on the cognitive function of the elderly people who are 60 years and older.

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Homozygosity for the APOE E4 Allele is Solely Associated with Lower Cognitive Performance in Brazilian Community-dwelling Older Adults – The Bambuí Study

Abstract: The APOE E4 allele was observed to have a dramatic effect on cognitive impairment, especially in homozygotes, which comprised approximately 2% of the population.

Cited by 6 publications

References 27 publications

ApoE4 genotype and cognitive performance in Korean health examinees with subjective memory complaints: A retrospective cross-sectional study

ApoE4 genotype and cognitive performance in Korean health examinees with subjective memory complaints: A retrospective cross-sectional study

Apolipoprotein E polymorphism and functional disability in Brazilian elders: the Bambuí Health and Aging Study

ApoE Type 4 Allele Affects Cognitive Function of Aged Population in Tianjin City, China

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