Homozygosity for the rs9939609T allele of the FTO gene may have protective effect on becoming overweight in survivors of childhood acute lymphoblastic leukaemia

Skoczeń, Szymon; Bik-Multanowski, Mirosław; Balwierz, Walentyna; Pietrzyk, Jacek J; Surmiak, Marcin; Strojny, Wojciech; Galicka-Latała, Danuta; Goździk, Jolanta

doi:10.1007/s12041-011-0089-3

Cited by 10 publications

(7 citation statements)

References 15 publications

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“…[16] Moreover, another study demonstrated the incidence rate of obesity to be 15% and 40% at the time of diagnosis and at the end of treatment, respectively. [17] Our study findings revealed a significant increase in BMI 6 months after starting the treatment, which is in line with the findings obtained by Zhang et al [14] In the present study, BMI followed an increasing trend 2 years after starting the treatment. Afterward, a slight decrease was observed, and then, BMI increased again with a slower slope.…”

Section: Discussionsupporting

confidence: 93%

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2017

Indian Journal of Medical and Paediatric Oncology

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Introduction: Obesity is among the medical problems in survivors of childhood acute lymphoblastic leukemia (ALL). These patients are at risk of metabolic syndrome (MS). The present study aimed to follow the patients with ALL regarding the incidence of MS. Patients and Methods: This study was conducted on all patients who referred to the oncology clinic from July 2012 to July 2013. The exclusion criteria of the study were ALL relapse, secondary malignancy, hypothyroidism, Down syndrome, and below 2 years of age. ALL had to be diagnosed at least 12 months before enrollment into this study. MS was assessed by serum triglyceride, cholesterol, fasting blood sugar, leptin, and insulin levels. Besides, body mass index (BMI) and blood pressure (BP) were measured at diagnosis and at the last visit. Results: This study was conducted on 53 patients (male = 35, female = 18). At the end of the study, 13 patients (24.53%) were overweight compared to 3 patients at diagnosis (P = 0.04). The mean blood leptin level was higher in overweight patients compared to the others (P = 0.001). MS was detected in 21 patients (39.6%), including 12 males and 9 females. In addition, the BMI Z-score significantly increased over the study period (P = 0.001). Conclusions: Being overweight is a complication of ALL treatment, which is associated with elevated blood leptin level and BMI Z-score. Therefore, MS criteria, such as BP, weight, and serum triglyceride level, should be taken into account in each visit.

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Section: Discussionsupporting

confidence: 93%

“…Overall, many factors may be involved in increase of BMI in the children with ALL. These factors include high-dose steroids, [13] sex, [17] CRT, [5,22] physical activity, [26] and resistance to leptin. [6] Thus, these children's parents should pay more attention to their children's nutrition.…”

Section: Discussionmentioning

confidence: 99%

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2017

Indian Journal of Medical and Paediatric Oncology

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“…Another group of investigators evaluated associations between obesity and polymorphisms of the fat mass and obesity associated ( FTO ) gene. Among ALL survivors treated with CRT, they found lower rates of obesity in those homozygous for the T allele at rs9939609 when compared to those with at least one copy of the A allele [34]. While the exact function of the FTO gene is unknown, it has been associated with regulation of global metabolic rate, energy expenditure, energy homeostasis, body size, and body fat accumulation [35, 36].…”

Section: Genetic Mediators Of Obesitymentioning

confidence: 99%

Obesity and Metabolic Syndrome Among Adult Survivors of Childhood Leukemia

Gibson

Ehrhardt

Ness

2016

Curr. Treat. Options in Oncol.

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Opinion statement Treatment-related obesity and the metabolic syndrome in adult survivors of childhood acute lymphoblastic leukemia (ALL) are risk factors for cardiovascular disease. Both conditions often begin during therapy. Preventive measures, including dietary counseling and tailored exercise should be initiated early in the course of survivorship, with referral to specialists to optimize success. However, among adults who develop obesity or the metabolic syndrome and who do not respond to lifestyle therapy, medical intervention may be indicated to manage underlying pathology, such as growth hormone deficiency, or to mitigate risk factors of cardiovascular disease. Because no specific clinical trials have been done in this population to treat metabolic syndrome or its components, clinicians who follow adult survivors of childhood ALL should use the existing American Heart Association/National Heart Lung and Blood Institute Scientific Statement to guide their approach.

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“…However, no relationship was found between the FTO gene polymorphism and body mass or risk of overweight/obesity in subjects after anticancer treatment. In Skoczen et al's study, a group of Polish children subjected to irradiation due to ALL showed a lower frequency of the T allele at the site of the FTO gene rs9939609 in subjects with overweight [ 24 ], which may be connected to a protective effect of the T allele preventing binge eating [ 25 ]. Polymorphisms of FTO and adiponectin genes can be used (in addition to age and BMI at time of diagnosis) in the model of obesity prediction after breast cancer treatment [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular Risk Factors after Childhood Cancer Treatment Are Independent of the FTO Gene Polymorphism?

Sawicka-Żukowska

Krawczuk‐Rybak

Bernatowicz

et al. 2018

International Journal of Endocrinology

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The study objective was to assess the prevalence of cardiovascular disease risk factors in patients treated for childhood cancer (N = 101) and to determine the involvement of clinical (cancer type and therapy) and/or genetic (FTO gene rs9939609 polymorphism) factors. Anthropometric features, laboratory findings, and standardized osteodensitometric indices (fat and lean mass) were considered. Overweight/obesity was found in 17.82% of the patients; however, central adiposity was found in as many as 42.5%. At least one abnormality in lipid metabolism was observed in 35.6%. Densitometry revealed elevated levels of fat mass in 44.55% of the patients. None of the parameters studied were associated with the FTO gene polymorphism. Standardized waist circumference was significantly higher in patients treated for leukemia than those treated for solid tumors (p = 0.04). Our findings indicate a high rate of central adiposity among childhood cancer survivors, especially leukemia patients. The prevalence of risk factors of cardiovascular disease after anticancer therapy is not FTO gene polymorphism-dependent.

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Homozygosity for the rs9939609T allele of the FTO gene may have protective effect on becoming overweight in survivors of childhood acute lymphoblastic leukaemia

Cited by 10 publications

References 15 publications

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Untitled

Obesity and Metabolic Syndrome Among Adult Survivors of Childhood Leukemia

Cardiovascular Risk Factors after Childhood Cancer Treatment Are Independent of the FTO Gene Polymorphism?

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