Homozygous complement factor deficiency and primary antiphospholipid syndrome: a clinical and serological study.

Juliá, M. R.; Matamoros, N.; Milà, Joan; Bestard, X; Gascó, J; A, Morey; Amer, Galal Mohamed

doi:10.1136/ard.54.6.530

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Observations In People With Antiphospholipid Syndrome1

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2007

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“…This association of primary APS with C4 null alleles was confirmed by other groups as well [16]. Homozygous C2 deficiency was identified in another individual with primary APS, whose sister had previously died at age 30 from myocardial infarction after years of migraine [17]. The genes for C2 and C4 are located within the major histocompatibility complex (MHC) on chromosome 6, and deficiency alleles are linked with an "autoimmune" extended MHC haplotype (HLA-B8, DR3) that itself has been linked to primary APS in other studies [18].…”

Section: Observations In People With Antiphospholipid Syndromesupporting

confidence: 66%

Role of complement in antiphospholipid antibody-mediated thrombosis

O’Neil

2007

Curr Rheumatol Rep

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The mechanisms by which an antibody that reacts with phospholipids (universal components of mammalian membranes) causes thrombosis are not immediately obvious. The development of an animal model of antiphospholipid antibody syndrome has moved the field forward in dissecting the pathogenesis of antiphospholipid antibody syndrome and has implicated the complement system in the mechanism of disease. Understanding complement's role in promoting thrombosis will be important in designing safer, more effective approaches to the treatment of patients with antiphospholipid antibodies, and may shed light on which patients are at greatest risk for thrombosis, perhaps permitting primary prophylaxis before irreversible tissue and organ damage occur.

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Section: Observations In People With Antiphospholipid Syndromesupporting

confidence: 66%

Role of complement in antiphospholipid antibody-mediated thrombosis

O’Neil

2007

Curr Rheumatol Rep

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show abstract

Homozygous complement factor deficiency and primary antiphospholipid syndrome: a clinical and serological study.

Cited by 1 publication

References 11 publications

Role of complement in antiphospholipid antibody-mediated thrombosis

Role of complement in antiphospholipid antibody-mediated thrombosis

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