“…Fibulin-1, -2, -4, and -5 colocalize with elastic fibers and bind tropoelastin (19,27,36), whereas the elastic fiber binding properties of fibulin-3 and -6 have not been determined. In addition to tropoelastin, fibulin-5 was shown to bind N-terminal fragments of fibrillin-1 without interfering with either the homophilic interaction of fibrillin-1 or the heterotypic interaction of fibrillin-1 with tropoelastin (9). Binding of fibulin-5 to the integrin receptors ␣V3, ␣V5, and ␣91 in adhesion assays (22,23) suggests that fibulin-5 may serve to anchor tropoelastin to surrounding cells during assembly and/or final organization of functional elastic fibers.…”