Honey polyphenols: regulators of human microbiota and health

Cárdenas-Escudero, J.; Mármol-Rojas, C; Pintor, Santiago Escribano; Galán-Madruga, David; Cáceres, J. O.

doi:10.1039/d2fo02715a

Cited by 9 publications

(8 citation statements)

References 202 publications

(433 reference statements)

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“…22 Besides being chemical markers, honey phenolic compounds are beneficial to human health, especially for patients with chronic diseases. 1 Chaste honey contains high levels of phenolic compounds, including apigenin, luteolin, neochlorogenic acid, kaempferide, epi-dihydrophaseic acid, salicylic acid, trans-cinnamic acid, kaempferitrin, quercetin, formononetin, eriodictyol, protocatechuic acid, apigetrin, chrysin, chlorogenic acid, vanillic acid, isoferulic acid, myricetin, ferulic acid, and 4-hydroxybenzoic acid (Table S2). These phenolic compounds are widely reported as common honey constituents.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Common characteristic phenolic compounds are utilized as chemical markers for identifying the origin of monofloral honey . Besides being chemical markers, honey phenolic compounds are beneficial to human health, especially for patients with chronic diseases …”

Section: Resultsmentioning

confidence: 99%

“…Honey is the most widely known Api-product (products originating from honeybees), and has served as a natural sweetener and medicine for hundreds of years. , Undergoing dehydrating and transforming with the honeybees’ specific substances, nectar ripens to honey, so-called “mature honey”. Thanks to its high nutrient content and various biological activities, honey is globally popular across diverse cultures. , Depending on its botanical origin, honey is classified as mono- or polyfloral.…”

Section: Introductionmentioning

confidence: 99%

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Exploring the Formation of Chemical Markers in Chaste Honey by Comparative Metabolomics: From Nectar to Mature Honey

Yan,

Mu,

Yuan

et al. 2024

J. Agric. Food Chem.

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Identification of chemical markers is important to ensure the authenticity of monofloral honey; however, the formation of chemical markers in honey has received little attention. Herein, using comparative metabolomics, we first identified chemical markers in chaste honey and then explored their formation and accumulation from nectar to mature honey. We identified agnuside and p-hydroxybenzoic acid glucosides as chemical markers for chaste honey. Besides, we developed an UHPLC−MS/MS method for quantifying these markers and found that their levels varied significantly across sample sources. We compared the presence of these compounds in chaste nectar and mature honey. The outcomes underscore that these characteristic compounds are not simply delivered from nectar to mature honey, and activities of honeybees (collecting and processing) play a pivotal role in their formation and accumulation. These observations shed light on how mature honey can form its unique qualities with a rich assortment of natural bioactive compounds, potentially supporting health benefits.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Exploring the Formation of Chemical Markers in Chaste Honey by Comparative Metabolomics: From Nectar to Mature Honey

Yan,

Mu,

Yuan

et al. 2024

J. Agric. Food Chem.

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“…As the main functional components in honey, metabolites crucially contribute to the effects of health benefits of honey . Besides, establishing honey authenticity identification methods based on characteristic phytogenic components has become the object of multiple studies. , Thus, UHPLC-Q-TOF-MS/MS-based metabolomic analysis was conducted to screen characteristic phytogenic components that can discriminate between MH- Sco and other honeys.…”

Section: Resultsmentioning

confidence: 99%

3α-Hydroxylup-20(29)-ene-23,28-dioic Acid as a Phytogenic Chemical Marker for Authenticating Schefflera octophylla (Lour.) Harms Monofloral Honey

Wu,

Zhang,

et al. 2024

J. Agric. Food Chem.

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The monofloral honey from Schefflera octophylla (Lour.) Harms (MH-Sco) are of high economic value due to their rarity and potential medicinal benefits. However, the limited investigations on the relationship of phytogenic components between the plant S. octophylla (P-Sco) and MH-Sco have an impact on MH-Sco authentication. Herein, the tentative phytogenic markers of MH-Sco were screened by comparing the metabolites of MH-Sco obtained by ultrahigh-performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (UHPLC-Q-TOF-MS/MS)-based untargeted metabolomics with the identified phytogenic chemicals from P-Sco. Combined with the mass and NMR spectral information, 3α-hydroxylup-20(29)-ene-23,28-dioic acid (HLEDA) was finally identified as the phytogenic marker of MH-Sco. A targeted ultrahigh-performance liquid chromatography-triple quadrupole mass spectrometry (UHPLC-QqQ-MS/MS)-based method was established and validated based on the purified monomer standard to measure HLEDA levels in honey samples. HLEDA determined in MH-Sco was with the content from 0.303 to 0.440 mg/kg, while HLEDA was absent in honey samples from other botanical origins, indicating the reliability of HLEDA as a chemical marker in MH-Sco authentication. This study provides the theoretical basis and industry guidance for honey quality control for commercial consumption.

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“…Probiotics disrupt this processes by which oral bacteria adhere to proteins, hence inhibiting the production of biofilm. research has shown that probiotics enhance the treatment-induced mucositis 16 .…”

Section: Resultsmentioning

confidence: 99%

Impact of Microbial Intake for Gums and Periodontal Health in Children Receiving Chemotherapy

Jacob,

A. Razzak Mahmood,

et al. 2024

Int J Tre Onc Sci

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Probiotics comprised of living microorganisms and are devoid of any detrimental impacts on health. When consumed in sufficient amounts, they provide nutritional advantages. The prevalent oral infections primarily target the periodontal and dental tissues inside the mouth cavity. This study aims to investigate the effectiveness of oral probiotics in combating bacteria associated with periodontal and dental diseases. Moreover, it aims to evaluate the gum and periodontal well-being of children receiving chemotherapy following the intake of oral probiotics. Seventy children, aged 4 to 16 years and undergoing chemotherapy, were randomly assigned to either the control or test group, which received probiotics, over a period of ninety days. Various evaluations, including the examination of gum and teeth-supporting structures, oral cleanliness, and testing for caries activity, were conducted at different intervals. SPSS 19.0 was utilized for statistical analysis. Among participants in the treatment group, the administration of oral probiotics resulted in a noteworthy reduction in biofilm accumulation over the observation period (P < 0.05). The test group exhibited an improvement in the condition of the gums and supporting structures of the teeth (P < 0.05). A caries activity assessment was conducted using the Snyder test. Among the children in the research group, 10 were found to have a score of 1, while eight exhibited a score of 2. None of the children in the research group displayed a score of 3. The findings indicated that consistent intake of oral probiotics leads to a significant decrease in the build-up of biofilm, the production of tartar, and the occurrence of tooth decay within the experimental group.

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Honey polyphenols: regulators of human microbiota and health

Abstract: A comprehensive review of research over the last decade was conducted to carry out this work. The main objective of this work is to present relevant evidence of the effect...

Cited by 9 publications

References 202 publications

Exploring the Formation of Chemical Markers in Chaste Honey by Comparative Metabolomics: From Nectar to Mature Honey

Exploring the Formation of Chemical Markers in Chaste Honey by Comparative Metabolomics: From Nectar to Mature Honey

3α-Hydroxylup-20(29)-ene-23,28-dioic Acid as a Phytogenic Chemical Marker for Authenticating Schefflera octophylla (Lour.) Harms Monofloral Honey

Impact of Microbial Intake for Gums and Periodontal Health in Children Receiving Chemotherapy

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