Honey potentially mitigates morphine analgesic tolerance and physical dependence in rats

Abstract

Introduction:Honey has been used traditionally in medicine as well as food supplements. Honeybees are said to be able to cure many diseases. However, its influences on opioid tolerance and dependence have not yet been clarified.Materials and Methods:Adult male SpragueDawley rats were rendered tolerant to the analgesic effect of morphine by injection of morphine (10 mg/kg, i.p.) twice daily for 14 days. To develop morphine dependence rats given escalating doses of chronic morphine. To determine the effect of stingless bee honey on the development of morphine tolerance and dependence. The hotplate and naloxone precipitation tests were used to assess the degree of tolerance and dependence, respectively.The results: Our results showed that chronic morphine-injected rats displayed tolerance to the analgesic effect of morphine as well as morphine dependence. Methadone+morphine (MetM), methadone+morphine+ honey (MetMH) and morphine+Honey (MH) significantlylower the development of morphine tolerance with p-value p<0.05. In addition, concomitant treatment of morphine with MH and MetMH attenuated almost all of the naloxone-induced withdrawal signs which include abdominal contraction, diarrhea, pertussis, teeth chattering, and jumping. Conclusion: The data indicate that honey has a potential to reduce tolerant and dependence property.

Phytochemical compound and non-cytotoxicity effect of sting bee and stingless bee honey against normal human gingival cell lines

“…AH, product of a sting bee variety is known for its pale-yellow colour, herbaceous and delicate flavour 3 . These both honey varieties have shown in various studies to have medicinal potential 4,5,6,7 . Nowadays, it is being actively investigated to confirm its medicinal effects and uses in various parameters of medicine.…”

D4 and D5 dopamine receptor mRNA expression in human peripheral blood lymphocytes among cooccurring opioid and amphetamine-type stimulants use disorder undergoing methadone maintenance therapy

“…In Malaysia, popular ATS include crystalline methamphetamine and amphetamine/methamphetamine tablets while heroin and morphine remain the most commonly misused opioid 4 . Methadone maintenance treatment (MMT) is a comprehensive and effective substitution treatment for opioid use disorder and was commenced in Malaysia in 2006 by Malaysia Ministry of Health 5,6 . In comparison to opioid, methadone has fewer side effects, improves mental and physical well-being and reduces mortality 7, 8, 9. Dopaminergic system in the brain reward centrelocated in the mesolimbic area serves as the major target in drug addiction 10 , 11 .…”