Honey prevents hepatic damage induced by obstruction of the common bile duct

Ergüder, Berrin İmge; Kılıçoğlu, Sibel Serin; Namuslu, Mehmet; Kilicoglu, Bulent; Devrım, Erdinç; Kısmet, Kemal; Durak, İlker

doi:10.3748/wjg.14.3729

Cited by 24 publications

(24 citation statements)

References 14 publications

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“…29,31 MTX administration significantly increased the activity of ALT (a transaminase enzyme which is elevated in liver diseases) in the serum, which is associated with hepatic necrosis. 32 Serum levels of urea, indicators of renal function, increased in MTX-group suggesting a nephrotoxic condition, and uric acid levels in the serum and urine decreased when compared to those of the control group. The decreased output of uric acid is a direct consequence of decreased purine catabolism, and hence an indication of a possible treatment-related decrease in nucleic acid turnover (Figure 3).…”

Section: Discussionmentioning

confidence: 99%

Decrease of adenosine deaminase activity and increase of the lipid peroxidation after acute methotrexate treatment in young rats: protective effects of grape seed extract

Pinheiro

Pimentel

Bona

et al. 2009

Cell Biochemistry & Function

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The methotrexate (MTX) is an anti-folate used to treat cancer and some inflammatory diseases. The efficacy of MTX is often limited by its severe toxicity. The present study was undertaken to determine whether Grape seed (Cabernet Sauvignon) extract (GSE) could ameliorate the MTX-induced oxidative injury and the effect on adenosine deaminase activity (ADA) in rats. The rats were pretreated with 50 mg/kg of GSE, i.p., prior to MTX administration (10 mg/kg, i.p.) with a second dose given 4 h and a third dose 16 h after MTX administration. Biochemical parameters were investigated 48 h after the last MTX administration. The administration of MTX increased thiobarbituric acid reactive species (TBARS) levels in hippocampus, kidney and liver, whereas induced a significant decreased in the ADA activity in the cerebral cortex, kidney and liver tissues. MTX administration significantly increased the activity of ALT(alanine aminotransferase) and urea levels and decreased uric acid levels in the serum. Urinary uric acid levels decreased in the MTX group when compared to those of the control group. The GSE along with MTX-administration significantly reversed these parameters toward to near normal. These results indicated that GSE could reduce hepatic and nephritic damage induced by MTX-treatment in young rats therefore having free radical scavenging.

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Section: Discussionmentioning

confidence: 99%

Decrease of adenosine deaminase activity and increase of the lipid peroxidation after acute methotrexate treatment in young rats: protective effects of grape seed extract

Pinheiro

Pimentel

Bona

et al. 2009

Cell Biochemistry & Function

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“…Based on the previous observation we designed to investigate the supplementation of Honey on lipid profile and CRP because this issue may have clinically important implication for high risk patient with coronary heart disease [25]. Similar hepatoprotective effect of honey was also reported in diabetic rats with obstruction of the common bile duct [26]. These findings, generally, suggest that oxidative stress in the liver may contribute to the hepatoprotective effect of honey.…”

Section: Groupsmentioning

confidence: 83%

Effects of Honey Supplementation on Hepatic and Cardiovascular Disease(CVD) Marker in Streptozotocin-Induced Diabetic Rats

Sohanur¹,

S²

2015

J Diabetes Metab

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Introduction: Honey is not just a sweetener it is also a nature's gift to mankind. Natural honey has various ingredients in it that contribute to its incredible properties. Honey contain health-beneficial effects such as gastro protective, hepatoprotective, reproductive, hypoglycemic, antioxidant, antibacterial, and anti-inflammatory effects. For that reason, honey could be considered as a potential remedy for diabetes as well as Cardiovascular Disease (CVD). The objective of this study was to determine the phytochemical activity of honey and its role on hypoglycemic and hypolipidemic condition in Streptozotocin-induced diabetic rats. Material and method:The Experimental rats were divided into six groups (n=6). Diabetes Mellitus (DM) was induced by single intraperitoneal injection (65 mg/kg BW) of freshly prepared Streptozotocin hydrate solution in 0.9% saline solution. Hyperlipidemic was induced by mixture of cholesterol (1.5 %) and cholic acid (0.5%) with diet of rats. At the end of the treatment, the blood glucose level and lipid profile was measured by using commercial kits.Result: Honey bee-treatment significantly decreases blood glucose level in diabetic rats. TC, TG, LDL, VLDL are significantly (p<0.05) decrease whereas HDL significantly increase (p<0.001). The SGPT, SGOT and CRP were significantly decrease (p<0.05). The total phenolic and flavonoid were determined by Folin-Ciocalteu and colorimetric assay method where some flavonoid decreases diabetic condition as well as CVD. Honey has also effect of hepatoprotective activity. Conclusion:On the basis of above findings, it can be concluded that, supplementation of honey could significantly contribute to control blood glucose level as well as lipid profile in diabetic subjects.

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“…Honey contains fructose, glucose, and compounds which function as antioxidant, like phenolic compound, chrysin, pinobanksin, vitamin C, catalase, and pinocembrin (Chen et al, 2000;Nagai et al, 2006), and flavanoid compounds such as luteolin, quercetin, apigenin, fisetin, kaempferol, isorhamnetin, acacetin, tamarixetin, chrysin, and galangin (Erguder et al, 2008). Kandimalla (2006) stated that flavanoid has the ability to serve as a hepatoprotective that could lower enzim (SGPT, SGOT, ALP, and LDH) serums on carbon tetrachloride induced rats.…”

Section: Resultsmentioning

confidence: 99%

“…Honey is one of the most popular natural resources that is frequently used as traditional medicine (Erguder et al, 2008). Honey contains fructose, glucose, and material that functions as antioxidant, like phenolic compound, chrysin, pinobanksin, vitamin C, catalase, and pinocembrin (Chen et al, 2000;Nagai et al, 2006), and flavanoid compounds such as luteolin, quercetin, apigenin, fisetin, kaempferol, isorhamnetin, acacetin, tamarixetin, chrysin, and galangin (Erguder et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…It could be a form of remedy to some diseases, including heart disease. According to Erguder et al (2008), honey is useful for preventing heart damages due to bile duct obstruction. Meanwhile, based on the research conducted by Mahesh et al (2009), Indian honey could protect heart from oxidative damages and could be used as an effective hepatoprotector of heart damages due to paracetamol induction.…”

Section: Introductionmentioning

confidence: 99%

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Hepatoprotective Effect of Forest Honey on Carbon Tetrachloride Induced Female Wistar Rats

Linawati

2018

J.Pharm.Sci.Community

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Hepatoprotective effect study of forest honey had been conducted on a female rat induced with carbon tetrachloride (CCl4). The study aimed at obtaining the scientific data and the evidence of forest honey as hepatoprotective agent on the rat. The study was a true experimental study with a single factor completely randomized design. Thirty rats were randomly divided into six groups (n=5). Group I received carbon tetrachloride 2.0 mL/kgBW intraperitoneally, group II received olive oil 2.0 mL/kgBW intraperitoneally, group III received forest honey 8.1 mL/kgBW (6 days, peroral), groups IV, V, VI were given forest honey 3.6, 5.4, 8.1 mL/kgBW (6 days, peroral) and intraperitoneal induction of carbon tetrachloride 2 mL/kgBW on seventh day. The blood sample of all rats were taken for ALT-AST measurement and their liver were sampled for histological examination of the liver cell. Groups I and III on the seventh day, group II on the second day, groups IV,V,VI on the eighth day. The result showed that a forest honey can be used as a hepatoprotective agent on the female rat Wistar strain induced by carbon tetrachloride 2 mL/kgBW with doses 3.6, 5.4, 8.1 mL/kgBW. Keywords: ALT-AST, carbon tetrachloride, forest honey, liver histopathology 3,6; 5,4; 8,1 mL/kgBB (6 hari, p.o) 3,6; 5,4; dan 8,1 mL/kgBB. ABSTRAK Telah dilakukan penelitian efek hepatoprotektif madu hutan pada tikus betina terinduksi karbon tetraklorida (CCl4) dengan tujuan membuktikan efek hepatoprotektif madu hutan pada tikus galur wistar yang diinduksi karbon tetraklorida. Jenis penelitian ini adalah eksperimental murni dengan rancangan acak lengkap pola searah. Tiga puluh ekor tikus dibagi secara acak ke dalam enam kelompok (n=5). Kelompok I diberi karbon tetraklorida 2,0 mL/kgBB secara intraperitoneal (i.p). Kelompok II diberi olive oil 2,0 mL/kg BB secara i.p. Kelompok III diberi madu hutan 8,1 mL/kgBB (6 hari, peroral (p.o)); kelompok IV, V, VI diberi madu hutan

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Honey prevents hepatic damage induced by obstruction of the common bile duct

Abstract: Abstract

Cited by 24 publications

References 14 publications

Decrease of adenosine deaminase activity and increase of the lipid peroxidation after acute methotrexate treatment in young rats: protective effects of grape seed extract

Decrease of adenosine deaminase activity and increase of the lipid peroxidation after acute methotrexate treatment in young rats: protective effects of grape seed extract

Effects of Honey Supplementation on Hepatic and Cardiovascular Disease(CVD) Marker in Streptozotocin-Induced Diabetic Rats

Hepatoprotective Effect of Forest Honey on Carbon Tetrachloride Induced Female Wistar Rats

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