Honokiol: An anticancer lignan

Rauf, Abdur; Patel, Seema; Imran, Muhammad; Maalik, Aneela; Arshad, Muhammad Umair; Saeed, Farhan; Mabkhot, Yahia N.; Al–Showiman, Salim S.; Ahmad, Nazir; Elsharkawy, Eman

doi:10.1016/j.biopha.2018.08.054

Cited by 87 publications

(52 citation statements)

References 95 publications

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“…Activation of the death receptor mediated apoptotic pathway is primarily inhibited by cellular-caspase-8/FADD-like IL-1β-converting enzyme (FLICE) inhibitory protein (c-FLIP), which inhibits caspase-8 activation by preventing the recruitment of caspase-8 to the death inducing signalling complex [106]. However, honokiol was able to downregulate c-FLIP through the ubiquitin/proteasome-mediated mechanism, resulting in the sensitisation of non-small cell lung cancer cells to TRAIL-mediated apoptosis [107,108].…”

Section: Dual Induction Of Apoptotic and Necrotic Cell Deathmentioning

confidence: 99%

“…This arrest is associated with the suppression of cyclin-B1, CDC2, and cdc25C in honokiol-treated human gastric carcinoma and human neuroglioma cells [97,124,125], downregulation of cyclin dependent kinase (CDK)-2 and CDK-4, and the upregulation of cell cycle suppressors p21 and p27 in human oral squamous cell carcinoma (OSCC) cells [26,97]. In addition, the downregulation of c-Myc and class I histone deacetylases was also identified as other contributors to cell cycle arrest at the G0/G1 phase in prostate cancer cells [97,122] and acute myeloid leukemia respectively [44,101,108].…”

Section: Cell Cycle Arrestmentioning

confidence: 99%

“…Honokiol has been shown to block and inhibit EMT in many cancer cells such as breast cancer, melanoma, bladder cancer, human non-small cell lung cancer, and gastric cancer ( Table 1). Honokiol reduced steroid receptor coactivator-3 (SRC-3), matrix metalloproteinase (MMP)-2, and Twist1, preventing the invasion of urinary bladder cancer cells [108,143]. In addition, honokiol was also capable of inducing E-cadherin and repressing N-cadherin expression, thus inhibiting the EMT process in J82 bladder cancer cells [108,143].…”

Section: Epithelial-mesenchymal Transition (Emt)mentioning

confidence: 99%

“…Honokiol reduced steroid receptor coactivator-3 (SRC-3), matrix metalloproteinase (MMP)-2, and Twist1, preventing the invasion of urinary bladder cancer cells [108,143]. In addition, honokiol was also capable of inducing E-cadherin and repressing N-cadherin expression, thus inhibiting the EMT process in J82 bladder cancer cells [108,143]. In breast cancer cells, honokiol inhibits the recruitment of Stat3 on mesenchymal transcription factor Zeb1 promoter, resulting in decreased Zeb1 expression and nuclear translocation [144].…”

Section: Epithelial-mesenchymal Transition (Emt)mentioning

confidence: 99%

“…Twist1, a basic helix-loop-helix domain-containing transcription factor, promotes tumour metastasis by inducing EMT, and can be upregulated by multiple factors, including SRC-1, STAT3, MSX2, HIF-1α, integrin-linked kinase, and NF-κB. The capability of honokiol in targeting Twist1 can be regarded as a promising therapy for metastatic cancer [108,146].…”

Section: Epithelial-mesenchymal Transition (Emt)mentioning

confidence: 99%

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Honokiol: A Review of Its Anticancer Potential and Mechanisms

Ong

Lee

Tang

et al. 2019

Cancers

131

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Cancer is characterised by uncontrolled cell division and abnormal cell growth, which is largely caused by a variety of gene mutations. There are continuous efforts being made to develop effective cancer treatments as resistance to current anticancer drugs has been on the rise. Natural products represent a promising source in the search for anticancer treatments as they possess unique chemical structures and combinations of compounds that may be effective against cancer with a minimal toxicity profile or few side effects compared to standard anticancer therapy. Extensive research on natural products has shown that bioactive natural compounds target multiple cellular processes and pathways involved in cancer progression. In this review, we discuss honokiol, a plant bioactive compound that originates mainly from the Magnolia species. Various studies have proven that honokiol exerts broad-range anticancer activity in vitro and in vivo by regulating numerous signalling pathways. These include induction of G0/G1 and G2/M cell cycle arrest (via the regulation of cyclin-dependent kinase (CDK) and cyclin proteins), epithelial-mesenchymal transition inhibition via the downregulation of mesenchymal markers and upregulation of epithelial markers. Additionally, honokiol possesses the capability to supress cell migration and invasion via the downregulation of several matrix-metalloproteinases (activation of 5 AMP-activated protein kinase (AMPK) and KISS1/KISS1R signalling), inhibiting cell migration, invasion, and metastasis, as well as inducing anti-angiogenesis activity (via the down-regulation of vascular endothelial growth factor (VEGFR) and vascular endothelial growth factor (VEGF)). Combining these studies provides significant insights for the potential of honokiol to be a promising candidate natural compound for chemoprevention and treatment.

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Section: Dual Induction Of Apoptotic and Necrotic Cell Deathmentioning

confidence: 99%

Section: Cell Cycle Arrestmentioning

confidence: 99%

Section: Epithelial-mesenchymal Transition (Emt)mentioning

confidence: 99%

Section: Epithelial-mesenchymal Transition (Emt)mentioning

confidence: 99%

Section: Epithelial-mesenchymal Transition (Emt)mentioning

confidence: 99%

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Honokiol: A Review of Its Anticancer Potential and Mechanisms

Ong

Lee

Tang

et al. 2019

Cancers

131

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Polyphenols for Textile‐Based Application

Yusuf,

Jayant,

Khan

2024

Science and Engineering of Polyphenols

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Photosensitizers Enable the Formation of Biphenyls with UV‐LEDs and Sunlight

Haensch,

Hertweck

2024

Chemistry A European J

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The regioselective synthesis of biphenyls, which are economically important pharmaceuticals, agrochemicals, and liquid crystals, is a challenging task. Current methods rely on metal‐dependent cross‐coupling reactions, which unfortunately require the use of harmful halogenated aryls and heavy metal catalysts that are toxic and difficult to remove from the final products. Recently, we have circumvented these problems by developing a metal‐free and broadly applicable photochemical method for biphenyl synthesis using UV‐C light, called photosplicing. Here we present an improved method using photosensitizers in combination with UV‐B, UVA light, or sunlight. Using a high‐precision flow reactor with deep‐UV LEDs, we investigated the ability of commonly available organic photosensitizers to enhance the photosplicing reaction and identified a number of suitable photosensitizers with the required triplet energy. This method allows for easy batch synthesis of biaryls in borosilicate glassware and paves the way for their large‐scale production without the need for flow reactors.

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Honokiol: An anticancer lignan

Cited by 87 publications

References 95 publications

Honokiol: A Review of Its Anticancer Potential and Mechanisms

Honokiol: A Review of Its Anticancer Potential and Mechanisms

Polyphenols for Textile‐Based Application

Photosensitizers Enable the Formation of Biphenyls with UV‐LEDs and Sunlight

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