Hop-Derived Iso-α-Acids in Beer Improve Visual Discrimination and Reversal Learning in Mice as Assessed by a Touch Panel Operant System

Ayabe, Tatsuhiro; Ohya, Rena; Ano, Yasuhisa

doi:10.3389/fnbeh.2019.00067

Cited by 7 publications

(3 citation statements)

References 58 publications

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“…Hop-Derived Iso-α-Acid, a chemical component found in dark beer and other light drinks, has been associated with better visual memory in animal model studies [ 69 ]. Our finding on beer and other light drinks use did not comply with this finding, as we found a negative association between beer and other light drinks use frequency and visual memory.…”

Section: Discussionmentioning

confidence: 99%

Visual memory and alcohol use in a middle-aged birth cohort

Mazumder,

Barnett,

Halt

et al. 2024

BMC Public Health

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Light and moderate alcohol use has been reported to be associated with both impaired and enhanced cognition. The purpose of this study was to explore whether there was a linear relationship between visual memory and alcohol consumption in males and females in a large middle-aged birth cohort population in cross-sectional and longitudinal settings. Data were collected from 5585 participants completing 31-year (1997–1998) and 46-year (2012–2014) follow-ups including Paired Associate Learning (PAL) test at 46-years follow-up. The participants were originally from 12,231 study population of the Northern Finland Birth Cohort 1966 (NFBC1966). The PAL test was conducted to assess visual memory. Reported alcohol use was measured as total daily use of alcohol, beer, wine, and spirits converted into grams and as frequency and amount of use of beer, wine, and spirits. The total daily alcohol use was not associated with reduced visual memory. The frequency of use of beer and wine in males was associated with better visual memory in cross-sectional and longitudinal settings. Using six or more servings of spirits was associated with worse visual memory in males in cross-sectional and longitudinal settings. Using six or more servings of spirits was associated with worse visual memory in males in cross-sectional and longitudinal setting. The study suggested a lack of a linear association between drinking and visual memory in the middle-aged population.

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Section: Discussionmentioning

confidence: 99%

Visual memory and alcohol use in a middle-aged birth cohort

Mazumder,

Barnett,

Halt

et al. 2024

BMC Public Health

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“…Hop-Derived Iso-α-Acid, a chemical component found in dark beer, has been associated with better visual memory in animal model studies [51]. Resveratrol, a polyphenol compound found in red wine, has been associated with better cognitive performance in a double-blind, placebo-controlled, crossover study in humans [52].…”

Section: Comparison With Other Studiesmentioning

confidence: 99%

Visual memory and alcohol use in a middle-aged birth cohort

Mazumder

Barnett

Halt

et al. 2022

Preprint

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Purpose: Light and moderate alcohol use has been reported to be associated with both impaired and enhanced cognition. The purpose of this study was to explore whether reported alcohol use was associated with reduced visual memory in males and females in a large middle-aged birth cohort population. Methods: The study population was from the Northern Finland Birth Cohort 1966 (NFBC1966). The Paired Associate Learning (PAL) test was conducted at the age of 46 years. Reported alcohol use was measured as gram per day use of total alcohol, beer, wine, and spirits, converted into 100% alcohol, and as frequency and amount of use of beer, wine, and spirits. Data on alcohol use was available at age 31 years and at age 46 years. Visual memory was assessed using two outcome variables of the PAL test: the Total errors adjusted score (TEAS) and First Trial Memory Score (FTMS). Both PAL TEA and PAL FTMS were used as continuous variables. The continuous variables were normalised using z-scores. Linear regression analysis was done to measure the associations. Adjusted models included education, marital status, diet, and physical activity. All analyses were done separately in males and in females. Results: Total alcohol consumption (grams per day) was 17.7 at age 31 years and 13.1 at age 46 years in males. The respective figures for females were 7.2 and 5.1. Grams per day use of total alcohol, beer, wine, and spirits, and frequency and amount of use of beer and wine were not associated with visual memory in males or females in cross-sectional or longitudinal settings. Using six or more servings of spirits was associated with worse visual memory in males in both cross-sectional and longitudinal settings. The frequency of use of wine in males was associated with better visual memory in cross-sectional settings. Conclusion: Most participants reported light drinking. The reported gram per day alcohol use was not associated with reduced visual memory in males or females, with the exception of spirits in males. The study suggests a lack of a linear association between drinking and visual memory in the middle-aged population.

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“…In addition to memory function, Ayabe et al [36] examined the effects of IAAs on prefrontal cortex (PFC)-associated higher-order cognitive functions, such as attention and executive function, using a rodent touch panel operant system. Rodent touch panel operant systems are recently established behavioral devices that offer the advantage of similarity to human cognitive assessment devices and thus good translatability [37].…”

Section: Iaas Enhance Cognitive Function Via Activation Of the Vagus mentioning

confidence: 99%

Improving Effects of Hop-Derived Bitter Acids in Beer on Cognitive Functions: A New Strategy for Vagus Nerve Stimulation

2020

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Dementia and cognitive decline are global public health problems. Moderate consumption of alcoholic beverages reduces the risk of dementia and cognitive decline. For instance, resveratrol, a polyphenolic compound found in red wine, has been well studied and reported to prevent dementia and cognitive decline. However, the effects of specific beer constituents on cognitive function have not been investigated in as much detail. In the present review, we discuss the latest reports on the effects and underlying mechanisms of hop-derived bitter acids found in beer. Iso-α-acids (IAAs), the main bitter components of beer, enhance hippocampus-dependent memory and prefrontal cortex-associated cognitive function via dopamine neurotransmission activation. Matured hop bitter acids (MHBAs), oxidized components with β-carbonyl moieties derived from aged hops, also enhance memory functions via norepinephrine neurotransmission-mediated mechanisms. Furthermore, the effects of both IAAs and MHBAs are attenuated by vagotomy, suggesting that these bitter acids enhance cognitive function via vagus nerve stimulation. Moreover, supplementation with IAAs attenuates neuroinflammation and cognitive impairments in various rodent models of neurodegeneration including Alzheimer’s disease. Daily supplementation with hop-derived bitter acids (e.g., 35 mg/day of MHBAs) may be a safe and effective strategy to stimulate the vagus nerve and thus enhance cognitive function.

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Hop-Derived Iso-α-Acids in Beer Improve Visual Discrimination and Reversal Learning in Mice as Assessed by a Touch Panel Operant System

Cited by 7 publications

References 58 publications

Visual memory and alcohol use in a middle-aged birth cohort

Visual memory and alcohol use in a middle-aged birth cohort

Visual memory and alcohol use in a middle-aged birth cohort

Improving Effects of Hop-Derived Bitter Acids in Beer on Cognitive Functions: A New Strategy for Vagus Nerve Stimulation

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