Hope, hype, cures, and persons with cerebral palsy

Turner, Leigh

doi:10.1111/dmcn.15064

Cited by 1 publication

(1 citation statement)

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“…Currently, a “cure” for sCP remains a pipe dream, fuelled by desperation and thwarted by both the heterogeneous nature of the syndrome and perhaps more importantly by ethical considerations amongst the adult398 cerebral palsy community that (rightly) demand a focus in improving their quality of life (see [ 396 , 397 ] for a detailed discussion on this topic). By contrast, a resetting of some research priorities towards maximizing the efficacy and safety of existing therapies (with two major interventions directly involving inhibitory inputs to MNs) or developing uncovering new targets or pharmacological agents that improve inhibitory neurotransmission or neural circuitry within the brain and spinal cord is well past due.…”

Section: Inhibitory Influences On Spastic Cerebral Palsymentioning

confidence: 99%

Inhibitory Synaptic Influences on Developmental Motor Disorders

Fogarty

2023

IJMS

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During development, GABA and glycine play major trophic and synaptic roles in the establishment of the neuromotor system. In this review, we summarise the formation, function and maturation of GABAergic and glycinergic synapses within neuromotor circuits during development. We take special care to discuss the differences in limb and respiratory neuromotor control. We then investigate the influences that GABAergic and glycinergic neurotransmission has on two major developmental neuromotor disorders: Rett syndrome and spastic cerebral palsy. We present these two syndromes in order to contrast the approaches to disease mechanism and therapy. While both conditions have motor dysfunctions at their core, one condition Rett syndrome, despite having myriad symptoms, has scientists focused on the breathing abnormalities and their alleviation—to great clinical advances. By contrast, cerebral palsy remains a scientific quagmire or poor definitions, no widely adopted model and a lack of therapeutic focus. We conclude that the sheer abundance of diversity of inhibitory neurotransmitter targets should provide hope for intractable conditions, particularly those that exhibit broad spectra of dysfunction—such as spastic cerebral palsy and Rett syndrome.

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Section: Inhibitory Influences On Spastic Cerebral Palsymentioning

confidence: 99%