<p style='text-indent:20px;'>In this paper, we consider a predator-prey model with memory-based diffusion. We first analyze the stability of all steady states in detail. Then by analyzing the distribution of eigenvalues, we find that the average memory period can cause the stability change of the positive steady state, and Hopf bifurcation occurs at the positive steady state. Moreover, from the central manifold theorem and the normal form theory, we give the direction and stability of Hopf bifurcation. The results show that, under certain conditions, a family of spatially inhomogeneous periodic solutions will bifurcate from the positive steady state when the average memory period appear.</p>