“…In this case, an evaluation of the findings and currently available literature appears to suggest that the reflectance confocal microscopy findings of MC are very characteristic and reproducible, even when MC lesions appear atypical clinically or on dermatoscopy. 1 , 2 …”
“…In this case, an evaluation of the findings and currently available literature appears to suggest that the reflectance confocal microscopy findings of MC are very characteristic and reproducible, even when MC lesions appear atypical clinically or on dermatoscopy. 1 , 2 …”
“…Other emerging diagnostic techniques that can aid in the diagnosis of MC include reflectance confocal microscopy (RCM) and line-field confocal optical coherence tomography (LC-OCT) [ 10 – 12 ]. Biopsy for histopathological evaluation is limited to atypical cases: the characteristic microscopic findings are represented by a crateriform invagination of hyperplastic epithelium composed of enlarged keratinocytes containing inclusion bodies known as Henderson–Patterson bodies [ 13 ]. Fig.…”
A large variety of treatments for molluscum contagiosum (MC) are available, but none are Food and Drug Administration (FDA) approved and there is no consensus on the optimal approach, mainly owing to a lack of high-level data. Physical modalities are widely used, but require repeated outpatient visits for administration, are painful and difficult to perform in children, and are associated with the possibility of residual scarring and post-inflammatory hypo- or hyperpigmentation. Two experimental topical drugs, a new standardized preparation of topical cantharidin, called VP-102, and a topical nitric oxide (NO)-releasing product containing berdazimer, called SB206, represent promising products that have been designed to overcome the limitations of current treatments. They have recently shown good results in terms of safety and efficacy in large cohorts of patients in phase III studies and have the potential to be the first FDA-approved therapies for the treatment of MC.
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